Conserved Protein Domain Family
ePHD_PHF14
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cd15674: ePHD_PHF14 
Extended PHD finger found in PHD finger protein 14 (PHF14) and similar proteins
The extended plant homeodomain (ePHD) zinc finger is characterized as Cys2HisCys5HisCys2His. This model includes the ePHD finger of PHF14. PHF14 is a novel nuclear transcription factor that controls the proliferation of mesenchymal cells by directly repressing platelet-derived growth factor receptor-alpha (PDGFRalpha) expression. It also acts as an epigenetic regulator and plays an important role in the development of multiple organs in mammals. PHF14 contains three canonical plant homeodomain (PHD) fingers and this non-canonical ePHD finger. It can interact with histones through its PHD fingers.
Links
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Statistics
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PSSM-Id: 277144
Aligned: 14 rows
Threshold Bit Score: 194.139
Created: 5-Mar-2014
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Zn binding siteputative
Feature 1: Zn binding site [ion binding site], 12 residue positions
Conserved feature residue pattern:C C H C C C C C H C C HClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structure evidence that human Borjeson-Forssman-Lehmann syndrome-associated protein PHF6 (PDB 4NN2) binds three Zn2+ ions through its ePHD finger
  • Comment:The extended PHD finger is characterized by Cys2HisCys5HisCys2His.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         #  #                 #  #                                 #  #              #   
O94880        385 CELCPNQDGIFKe-TDAGRWVHIVCALYVPGVAFGDIDKLRPVTltem-nyskYGAKECSFCED-PRFARTGVCISCDAG 461  human
NP_001135681  334 CELCPNQDGIFKe-TDAGRWVHIVCALYVPGVAFGDIDKLRPVTltem-nyskYGAKECSFCED-PRFARTGVCISCDAG 410  western clawe...
Q9GRZ5        165 CEFCPSRFGAFKraDIRGRWAHAICALYTHGVNYAQTHTRCGVSwehldnnahFGRRTCTACTD-KIEARFGIASRCESG 243  Caenorhabditi...
XP_002110130  173 CELCPNHGGILKq-TDTGRWVHLVCALYTAGVAFGDVDKLKPVIlsei-ssekWKNRECYICED-QRFAKTGICISCDAG 249  Trichoplax ad...
XP_005159747  351 CELCPSQDGIFKe-TDAGRWVHVVCALYVPGVAFGDIDKLRPVTltem-nyskYGAKECSLCED-TRFARTGVCISCDAG 427  zebrafish
NP_608836     184 CELCPNKGGIYKe-TDVGKWVHLICALYVPGVAFGEVEQLSSVTlfem-qyskWGAKVCSLCEN-ALFARTGVCIGCDAG 260  fruit fly
ELU07972      220 CELCPNSGGIYKe-TDTGRWVHLVCALYIPGVAFADVDRLSPVTlfem-ahtkWGSKECSFCED-DRFSATGVCISCDAG 296  Capitella teleta
XP_006811701  198 CELCPNMGGIFKq-TDTGRWVHVVCSLYIPGVTFGDVDKLSPVVlsel-gfnkWATRDCCYCED-DRFARTGIVIGCDAG 274  Saccoglossus ...
XP_002168113  197 CELCPNIGGIYKq-TDSGKWVHLVCALYTPDVGFRNVSKLQTVVledi-ksssWAARECTLCLD-DNFSKTGVCIDCDAG 273  Hydra vulgaris
EFW40837      375 CELCPNTGGAFKe-TDTGGWVHVLCALYTPGTEFGNLRTMEPVIlski--patSWGNTCVLCPEdSAASTVGVCVQCDAG 451  Capsaspora ow...

Feature 1          #    #  #                           #  #
O94880        462 MCRAYFHVTCAQKEGLLSEaaae----ediaDPFFAYCKQH 498  human
NP_001135681  411 MCRSYFHVTCAQKEGLLSEaaae----ediaDPFFAYCKQH 447  western clawed frog
Q9GRZ5        244 MCKEYLHVTCAQKLGLLVDetddn--dteiaVMRYFFCKKH 282  Caenorhabditis elegans
XP_002110130  250 LCKTYFHVTCAQRNGLLLQetse----qevaDPFFAYCKLH 286  Trichoplax adhaerens
XP_005159747  428 MCRSFFHVTCAQREGLLSEaaae----ediaDPFFAYCKQH 464  zebrafish
NP_608836     261 MCKTYFHVTCAQVAGFLIEahhe----ddaaDPFYAHCKVH 297  fruit fly
ELU07972      297 MCRNFFHVTCAQREGLLSEaspd----ediaDPFYAYCKQH 333  Capitella teleta
XP_006811701  275 MCRNYFHVTCAQRVGLLSEaspe----ediaDPFYAYCKVH 311  Saccoglossus kowalevskii
XP_002168113  274 LCKTSFHVSCAQRNGFLSDipdsdvnytddsDLLFAHCKLH 314  Hydra vulgaris
EFW40837      452 LCRQLFHASCAVKKGLLCEapsd----evvaDPYYANCMQH 488  Capsaspora owczarzaki ATCC 30864

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