Conserved Protein Domain Family
ePHD_BRPF
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cd15670: ePHD_BRPF 
Extended PHD finger found in BRPF proteins
The extended plant homeodomain (ePHD) zinc finger is characterized as Cys2HisCys5HisCys2His. This model corresponds to the ePHD finger of the family of BRPF proteins, which includes BRPF1, BRD1/BRPF2, and BRPF3. These are scaffold proteins that form monocytic leukemic zinc-finger protein (MOZ)/MOZ-related factor (MORF) H3 histone acetyltransferase (HAT) complexes with other regulatory subunits, such as inhibitor of growth 5 (ING5) and Esa1-associated factor 6 ortholog (EAF6). BRPF proteins have multiple domains, including a plant homeodomain (PHD) zinc finger followed by a non-canonical ePHD finger, a bromodomain and a proline-tryptophan-tryptophan-proline (PWWP) domain. This PHD finger binds to lysine 4 of histone H3 (K4H3), the bromodomain interacts with acetylated lysines on N-terminal tails of histones and other proteins, and the PWWP domain shows histone-binding and chromatin association properties.
Links
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Statistics
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PSSM-Id: 277140
Aligned: 19 rows
Threshold Bit Score: 209.884
Created: 5-Mar-2014
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Zn binding siteputative
Feature 1: Zn binding site [ion binding site], 12 residue positions
Conserved feature residue pattern:C C H C C C C C H C C HClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structure evidence that human Borjeson-Forssman-Lehmann syndrome-associated protein PHF6 (PDB 4NN2) binds three Zn2+ ions through its ePHD finger
  • Comment:The extended PHD finger is characterized by Cys2HisCys5HisCys2His.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         #  #                #  #                                #  #          #    #    
O95696        271 CVLCPNKGGAFKKTDDDRWGHVVCALWIPEVgFANTVFIEPIDGVRNIPPARWKLTCYLCKQKgvGACIQCHKANCYTAF 350  human
EPH53498      340 CVLCPNKGGAFKQTVDGRWAHIVCAMLVPETvLGNTVYLEPIDGVQHIPKARWTLKCYLCGKRt-GACIQCHKPNCYTSF 418  Capsaspora ow...
CBY31596      372 CVLCPSLNGAFKQTHDNRWCHVVCALWVPEVsFQNPVFLEPIDGFSKVPKARWNLKCYICKKA--GACIQCNKNACYTAF 449  Oikopleura di...
XP_003383026  354 CVLCPNKGGAFKQTIDGRWSHVICGLWIPEIqFANPVFLEPIDGINDVPSARWKLLCYICRKRt-GACIQCAKANCYVAF 432  Amphimedon qu...
CCD78184      389 CVLCPNRGGAFKKTTDDRWAHVICGLWVPEVmFANLTFLEPLEGIDRIAAARWRLQCFICKQRnvGACIQCHKSSCYRAF 468  Schistosoma m...
XP_003744983  508 CVLCPNRGGAFKQTSDSKWGHVVCALWVPEVyFANTVFLEPIDNICNIPAARWKLTCYICKKRgqGACIQCHKANCYTAF 587  western preda...
GAA99462      201 CVLCPAEGGAFKQTTANQWAHLLCAIWIPETgISNVVYMEPVDGVNHIPKSRWKLQCYLCKRRv-GACIQCANRSCYTAF 279  Mixia osmunda...
CDJ85791      218 CCLCPNTSGAFKQTSDGRWAHVICAIWLNEVhFGNLVFLEPIEGVDASLERRCKLKCLVCRKKm-GACLQCSTRSCLKAF 296  barber pole worm
Q12311        320 CLMCPSHTGAFKQTDTGSWVHNICALWLPELyFSNLHYMEPIEGVQNVSVSRWKLNCYICKKKm-GACIQCFQRNCFTAY 398  Saccharomyces...
EMR08940      119 CIFCPNTSGAFKQTSDNRWAHLLCAIWIPEVtVMNTVYQEPIDNIHKIPASRWKLICYICQQRm-GASIQCVNKSCYRAF 197  Pneumocystis ...

Feature 1         #  #                                                      #  #
O95696        351 HVTCAQKAGLYMKMepvkeltgg------------------------gttfsvrkTAYCDVH 388  human
EPH53498      419 HATCAQRAGLHLHFahlhsdeedeeeetpsdrrrsqhvsssarkrrnsflaeqdnFAFCDLH 480  Capsaspora owczarzaki ATCC 30864
CBY31596      450 HVTCAQQAGLYMEMkvqksdgin-----------------------gitsnkvtqTAFCHNH 488  Oikopleura dioica
XP_003383026  433 HVTCAQQANLCMKIemgkn-------------------------------gdickSAFCDSH 463  Amphimedon queenslandica
CCD78184      469 HVTCAQHAGLYMKIehtddpg----------------------------dlgirkSAFCDQH 502  Schistosoma mansoni
XP_003744983  588 HVTCAQQAGLYMKLeecrnge----------------------------qtgvrkTAFCDTH 621  western predatory mite
GAA99462      280 HVTCAREYNLYLKLrpvsaqa----------------------------dddsknEAYCHRH 313  Mixia osmundae IAM 14324
CDJ85791      297 HVTCAQQSGMTMKIessldpnn-------------------------aemmdvqrFVYCHLH 333  barber pole worm
Q12311        399 HVTCARRAGLYMSKgkctiqelas----------------------nqfsqkysvESFCHKH 438  Saccharomyces cerevisiae S288c
EMR08940      198 HVTCARRAKLYMPMkknn----------------------------------telKAYCDKH 225  Pneumocystis murina B123

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