Conserved Protein Domain Family
ePHD_Snt2p_like
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cd15667: ePHD_Snt2p_like 
Extended PHD finger found in Saccharomyces cerevisiae SANT domain-containing protein 2 (Snt2p) and similar proteins
The extended plant homeodomain (ePHD) zinc finger is characterized as Cys2HisCys5HisCys2His. This model includes the ePHD finger of Snt2p. Sntp2 is a yeast protein that may function in multiple stress pathways. It coordinates the transcriptional response to hydrogen peroxide-mediated oxidative stress through interaction with Ecm5 and the Rpd3 deacetylase. Snt2p contains a bromo adjacent homology (BAH) domain, two canonical PHD fingers, a non-canonical ePHD finger, and a SANT (SWI3, ADA2, N-CoR and TFIIIB) DNA-binding domain.
Links
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Statistics
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PSSM-Id: 277137
Aligned: 9 rows
Threshold Bit Score: 193.367
Created: 19-Mar-2014
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Zn binding siteputative
Feature 1: Zn binding site [ion binding site], 12 residue positions
Conserved feature residue pattern:C C H C C C C C H C C HClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structure evidence that human Borjeson-Forssman-Lehmann syndrome-associated protein PHF6 (PDB 4NN2) binds three Zn2+ ions through its ePHD finger
  • Comment:The extended PHD finger is characterized by Cys2HisCys5HisCys2His.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         #  #                               #  #                                        #
P53127       1108 CSMCPTKdydydryrsqsfkicpdALKCTSLGTWVHLVCSLFNedikygngqsmqp--------alnttavlikhsRFTC 1179 Saccharomyces...
XP_002556048 1158 CSLCNAKesdydggkkrlsrsipdALKITSNNTWCHVSCSLFNpdlsynslarlqi--------agnikstlikcgGKAC 1229 Lachancea the...
XP_001647256 1178 CVVCNGCegttdfqk-pqecgtknALKITSHGTWCHIICALFNdevkfgnpkslq---------piqnvslvsktiRRPC 1247 Vanderwaltozy...
XP_004177925 1154 CMLCNNKtmnptlnetnkiatyqnALKQTIQGSWCHVLCAVFNekikfvntkelkp--------itsaetvlqdhsNQIC 1225 Tetrapisispor...
EMG47050     1069 CCCCLAHesnyelsilgspfvrpdYLKPIDNGKWCHLLCAVFNndssilfnkpqevseihssisvvnvdkvflnnhRLVC 1148 Candida malto...
CDF88243     1151 CDLCQFRkcpeiiakgqqeplkleALKCTTVGSWVHVICAVYNvsikfvsskflqp--------ilntkfvlaeglCQTC 1222 Zygosaccharom...
BAO40574     1188 CSLCNGEkktlesadksspglfpeAFKRTMDGKWCHILCAAYCsdakfasgetlqp--------ilnvesvlfkqnTSKC 1259 Kluyveromyces...
XP_451628    1167 CVLCSTRdihnesakkvtarslpnALKCTADGSWCHILCAIYRsmtkfasietlqp--------iigtecsllnrnNINC 1238 Kluyveromyces...
CCE65065     1196 CGICSSKetlsggqklypgytpqqALKATSNGTWCHVICALYGkeikfgnseslq---------pvlnatsimhgeFNKC 1266 Tetrapisispor...

Feature 1           #         #  #       #  #                                           #  #
P53127       1180 GVCRIngGGLVKCnkCQY---RYHITCAQNSSnfklmfekknmsvdttl--pcikdvklndtytlrpILICDRH 1248 Saccharomyces cerev...
XP_002556048 1230 VICGVsgGGIVNCeeCDF---SCHVTCAQDYQkcsilfkklyvdddaq---fysvindkgqkfqikpIILCPKH 1297 Lachancea thermotol...
XP_001647256 1248 SLCLKpvGHLTACelCDN---IFHISCAQNEKefslffkkripteyevktnrfitdkvtnenyslkpTVICNAH 1318 Vanderwaltozyma pol...
XP_004177925 1226 KECSVigGGLIKCsvCDT---TVHASCARKNNkysmgffkeylingtannqktlydplqkshyvlkpEIYCDTH 1296 Tetrapisispora blat...
EMG47050     1149 EICESknGALIKCelCNDhphYYHVTCAQDTPnfklgftltdgkdha------ttvkvdnrsgtlkpILVCPKH 1216 Candida maltosa Xu316
CDF88243     1223 SICKLqgGGIIKCevCCT---RFHASCAYCTPgfelrikkialtdlqkn--epgvllsdgklyvlnpVAFCREH 1291 Zygosaccharomyces b...
BAO40574     1260 ELCKEscGVIVKCecCDD---CFHISCCANIEgfklgfkkelnsncsre--nfmtfcdgaleytvfpTLTCTKH 1328 Kluyveromyces marxi...
XP_451628    1239 NVCNLsgGLLVKCqsCDD---QFHPSCGADKEgfffgfkkqvksnvtnn--seisfvedqkdytaspVILCPKH 1307 Kluyveromyces lacti...
CCE65065     1267 GICQGigGVIEACmvCNY---NAHVTCAQWSKrfklgfqyaicdgstet-tpiihnssnkeqfllrpKMVCKVH 1336 Tetrapisispora phaf...

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