Conserved Protein Domain Family
ePHD_ATX3_4_5_like
?
cd15663: ePHD_ATX3_4_5_like 
Extended PHD finger found in Arabidopsis thaliana ATX3, -4, -5, and similar proteins
The extended plant homeodomain (ePHD) zinc finger is characterized as Cys2HisCys5HisCys2His. This subfamily includes the ePHD finger of A. thaliana histone-lysine N-methyltransferase arabidopsis trithorax-like proteins ATX3 (also termed protein SET domain group 14, or trithorax-homolog protein 3), ATX4 (also termed protein SET domain group 16, or trithorax-homolog protein 4) and ATX5 (also termed protein SET domain group 29, or trithorax-homolog protein 5), which belong to the histone-lysine methyltransferase family. These proteins show distinct phylogenetic origins from the family of ATX1 and ATX2. They are multi-domain proteins that consist of an N-terminal PWWP domain, a canonical PHD finger, this non-canonical extended PHD finger, and a C-terminal SET domain.
Links
?
Statistics
?
PSSM-Id: 277133
Aligned: 6 rows
Threshold Bit Score: 206.212
Created: 23-Jul-2014
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
Download Cn3D
 
Zn binding siteputative
Feature 1: Zn binding site [ion binding site], 12 residue positions
Conserved feature residue pattern:C C H C C C C C H C C HClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structure evidence that human Borjeson-Forssman-Lehmann syndrome-associated protein PHF6 (PDB 4NN2) binds three Zn2+ ions through its ePHD finger
  • Comment:The extended PHD finger is characterized by Cys2HisCys5HisCys2His.
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1         #  #                 #  #                                #  #         #    #    
Q9M364        603 CCLCPVKGGALKPSdvegLWVHVTCAWFRPEVgflnhenMEPAVGLfkipansFLKVCTICKQtHGSCVHCc--kCATHF 680  thale cress
Q9SUE7        649 CCLCPVKGGALKPTdvetLWVHVTCAWFQPEVcfaseekMEPAVGIlsipstnFVKICVICKQiHGSCTQCc--kCSTYY 726  thale cress
Q8GZ42        664 CCLCPVKGGALKPTdvetLWVHVTCAWFQPEVcfaseekMEPALGIlsipssnFVKICVICKQiHGSCTQCc--kCSTYY 741  thale cress
XP_009605368  665 CCLCPVKGGALKPTdidsLWVHVTCAWFRPEVafhnadkMEPAVGLlrippntFLKACVICKQvHGSCTQCc--kCATNF 742  Nicotiana tom...
EDQ57635      523 CCLCPVRGGALKPSntanLWVHVTCAWFVPEVkfknivkMEPAEGLtnvhlstFQQKCGICKQvHGVCVSCahknCRRSF 602  Physcomitrell...
EFJ18065      371 CCLCPVKGGALKPTtikgLWVHITCAWFIHEVtfkdevaMEPAAGItridlmrFREACAVCKQiHGVCIQCn--kCKTLY 448  Selaginella m...

Feature 1         #  #                           #  #
Q9M364        681 HAMCASRAGYNMELhc-leKNGvqrtrKSVYCSFH 714  thale cress
Q9SUE7        727 HAMCASRAGYRMELhc-leKNGqqitkMVSYCAYH 760  thale cress
Q8GZ42        742 HAMCASRAGYRMELhc-leKNGrqitkMVSYCSYH 775  thale cress
XP_009605368  743 HAMCALRAGYHMELnc-seKNGvqitrWLSYCAFH 776  Nicotiana tomentosiformis
EDQ57635      603 HIMCAFKSCYHMEMka-vtKNGlemtqMNLFCSIH 636  Physcomitrella patens
EFJ18065      449 HPMCALRAGYHMEVqisykKNGsfetrMITYCATH 483  Selaginella moellendorffii

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap