CDD Conserved Protein Domain Family: PHD4

cd15658: PHD4_NSD3

PHD finger 4 found in nuclear SET domain-containing protein 3 (NSD3)

NSD3, also termed histone-lysine N-methyltransferase NSD3, or protein whistle, or WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, or Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1-like protein 1, or WHSC1L1), is a lysine methyltransferase encoded by gene NSD3, which is amplified in human breast cancer cell lines. Moreover, translocation resulting in NUP98 fusion to NSD3 leads to the development of acute myeloid leukemia. NSD3 contains a catalytic suppressor of variegation, enhancer of zeste and trithorax (SET) domain, two proline-tryptophan-tryptophan-prolin motif (PWWP) domains, five plant-homeodomain (PHD) zinc fingers, and an NSD-specific Cys-His rich domain (Cys5HisCysHis). The SET domain is responsible for histone methyltransferase activity. The PWWP and PHD fingers are involved in protein-protein interactions. This model corresponds to the fourth PHD finger.

Feature 1 # # # # # # Q9BZ95 864 FCFVCARGlivqdhsdpmfssyaykshyllnes-nraelmklpmipsssaskkkcekgGRLLCCESCPASFHPECLSIEM 942 human EMC81514 854 FCFVCARGlvvqdhsdplfssyaykshyllnesnraelmklpmipppssaskkkcekgGKLLCCESCPASFHPECLSIDM 933 rock pigeon XP_005155379 977 WCFICARGllvhdhtdtilssytfkshylltesnraelmklpmipssssatkknigkgGRLLCCEACPASFHPECLKIEM 1056 zebrafish XP_006000427 889 FCFVCSRGllvqdlsdpllsayankshyllsesyraelmklpmipssssaskkkvekgGRLLCCESCPASFHPECLNIEM 968 coelacanth

Feature 1 # # Q9BZ95 943 PEGCWNCNDC 952 human EMC81514 934 PEGCWNCNDC 943 rock pigeon XP_005155379 1057 PEGTWLCGEC 1066 zebrafish XP_006000427 969 PEGSWYCNEC 978 coelacanth

Conserved Protein Domain FamilyPHD4_NSD3

Conserved Protein Domain Family
PHD4_NSD3