Conserved Protein Domain Family
PHD3_NSD2

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cd15654: PHD3_NSD2 
PHD finger 3 found in nuclear SET domain-containing protein 2 (NSD2)
NSD2, also termed histone-lysine N-methyltransferase NSD2, or multiple myeloma SET domain-containing protein (MMSET), or protein trithorax-5 Wolf-Hirschhorn syndrome candidate 1 protein (WHSC1), is overexpressed frequently in the t(4;14) translocation in 15% to 20% of multiple myeloma. It plays important roles in cancer cell proliferation, survival, and tumor growth, by mediating constitutive NF-kappaB signaling via the cytokine autocrine loop. It also enhances androgen receptor (AR)-mediated transcription. The principal chromatin-regulatory activity of NSD2 is dimethylation of histone H3 at lysine 36 (H3K36me2). NSD2 contains a catalytic suppressor of variegation, enhancer of zeste and trithorax (SET) domain, two proline-tryptophan-tryptophan-prolin motif (PWWP) domains, a high mobility group (HMG) box, five PHD (plant homeodomain) zinc fingers, and an NSD-specific Cys-His rich domain (Cys5HisCysHis). The SET domain is responsible for histone methyltransferase activity. The PWWP, HMG, and PHD fingers mediate chromatin interaction and recognition of histone marks. This model corresponds to the third PHD finger.
Statistics
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PSSM-Id: 277124
Aligned: 6 rows
Threshold Bit Score: 103.002
Created: 9-Jan-2014
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Zn binding siteputative
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C [CH] H [CH] C [CH]Click to see conserved feature residue pattern help
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1          #  #                    #  #    #    #              #  #
O96028        763 SCVSCHASNPSNPRp---SKGKMMRCVRCPVAYHSGDACLAAGCsVIASNSIICTAH 816  human
XP_004911328  707 RCATCYFSNPSNPRa---SKGKMVRCVRCPLAYHGAESCIVAGCtALTSTSIICSSH 760  western clawed frog
EMP39387      801 SCVSCHVTNPSNPRi---SKGKMMRCIRCPVAYHAGDVCIAAGCaVITSNSIVCTNH 854  green sea turtle
XP_006004824  831 TCVSCQAAYPTNPRa---TKGKMVRCIRCPVAYHGGDLCIAAGCaILTANSIICTNH 884  coelacanth
XP_007898577  845 SCISCHATNATNPSnprvTKGRMMRCVRCPVAYHGGETCIAAGSvVLAANSIICTSH 901  elephant shark
AAI71696      855 TCLSCHYSGRAACKa---TKGKMMRCLRCPVAYHVGDLCVAAGSeMISSSAIVCTNH 908  zebrafish

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