4N3W


Conserved Protein Domain Family
PHD_CBP
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cd15647: PHD_CBP 
Click on image for an interactive view with Cn3D
PHD finger found in CREB-binding protein (CBP)
CBP, also termed as KAT3A, is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CBP is also known as CREBBP, since it specifically interacts with the phosphorylated form of cyclic adenosine monophosphate-responsive element-binding protein (CREB). It augments the activity of phosphorylated CREB to activate transcription of cAMP-responsive genes. CBP contains a cysteine-histidine rich region, a KIX (CREB interaction) domain, a plant homeodomain (PHD) finger, a HAT domain, followed by a SRC interaction domain.
Links
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Statistics
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PSSM-Id: 277117
Aligned: 5 rows
Threshold Bit Score: 68.4713
Created: 14-Aug-2014
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Zn binding siteputative
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C C H C C CClick to see conserved feature residue pattern help
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          ##                                                                             
4N3W_A        119 YCCGRkyefspqtlccygkqlctiprdaayysyqnryhfcekcfteiqgenvtlgddpsqpqttiskdqfekkkndtldp 198  human
EOB05314     1182 YCCGRkyefspqtlccygkqlctiprdaayysyqnryhfcekcfteiqgenvtlgddpsqpqttiskdqfekkkndtldp 1261 mallard
NP_001088637 1189 YCCGRkfefspqtlccygkqlctisrdaayysyqnryhfcekcfteiqgenvtlgddpsqsqttiskeqfekkkndmlds 1268 African clawe...
XP_007891802 1236 YCCGRkyefspqtlccygkqlctiprdstyfsyqnryhfcekcfneiqgdsvtlgddpaqpqttiskdqfekkkndsldp 1315 elephant shark
XP_005161826 1091 YCCGRkyefspqtlccygkqlctiprdgtyysyqnryhfcekcfneiqgdsvtlgddpaqpqtmiskdqferkkndtldp 1170 zebrafish

Feature 1              #  #    #  #             #  #  
4N3W_A        199 ePFVDCKECGRKMHQICVLHYDiIWPSGFVCDNCLK 234  human
EOB05314     1262 ePFVDCKECGRKMHQICVLHYDiIWPSGFVCDNCLK 1297 mallard
NP_001088637 1269 ePFVDCKECGRKMHQICVLHYDiIWPSGFVCDNCLK 1304 African clawed frog
XP_007891802 1316 ePFVECKDCGRKMHQICVLHNEtIWPSGFVCDNCLK 1351 elephant shark
XP_005161826 1171 ePFVECKDCGRKMHQICVLHYEvIWPSGFICDNCLK 1206 zebrafish

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