4BHW


Conserved Protein Domain Family
PHD_p300
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cd15646: PHD_p300 
Click on image for an interactive view with Cn3D
PHD finger found in histone acetyltransferase p300
p300, also termed KAT3B, or E1A-associated protein p300 (EP300), is a paralog of CREB-binding protein (CBP). It is involved in E1A function in cell cycle progression and cellular differentiation. It functions as an intrinsic HAT, as well as a factor acetyltransferase (FAT) for many transcription regulators. And thus, p300 serves as a scaffold or bridge for transcription factors and other components of the basal transcription machinery to facilitate chromatin remodeling and to activate gene transcription. p300 contains a cysteine-histidine rich region, KIX (CREB interaction) domain, a plant homeodomain (PHD) finger, a HAT domain, followed by a SRC interaction domain.
Links
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Statistics
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PSSM-Id: 277116
Aligned: 4 rows
Threshold Bit Score: 80.6764
Created: 14-Aug-2014
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Zn binding siteputative
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C C H C C CClick to see conserved feature residue pattern help
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          ##                                                                             
4BHW_A        130 YCCGRklefspqtlccygkqlctiprdatyysyqnryhfcekc----------fneiqgesvslgddpsqpqttinkeqf 199  human
XP_001233888 1176 YCCGRklefspqtlccygkqlctiprdatyysyqnryhfcekc----------fneiqgesvslgddpsqpqttinkeqf 1245 chicken
XP_004913855 1198 YCCGRklefspqtlccygkqlctiprdatyysyqnsspkyglladryhfcekcfneiqgecvslgddptqpqttiskdqf 1277 western clawe...
CBN81203     1304 YCCGRklefspqtlccygkqlctiprdaayfsyqnryhfcekc----------fneiqgetvslgddptqpqtsinkdqf 1373 European seabass

Feature 1                        #  #    #  #             #  #  
4BHW_A        200 skrkndtldpeLFVECTECGRKMHQICVLHheiiwpAGFVCDGCLK 245  human
XP_001233888 1246 skrkndtldpeLFVECIECGRKMHQICVLHneiiwpSGFVCDGCLK 1291 chicken
XP_004913855 1278 skrkndtldpeQYVECLECGRKMHQICVLHnetiwpTGFVCEGCLK 1323 western clawed frog
CBN81203     1374 ekkkndtldpeLLVECMDCGRRMHQICVLHndtiwpSGFVCEGCLK 1419 European seabass

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