Conserved Protein Domain Family
PHD_PHF20
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cd15634: PHD_PHF20 
PHD finger found in PHD finger protein 20 (PHF20)
PHF20, also termed Glioma-expressed antigen 2, or hepatocellular carcinoma-associated antigen 58, or novel zinc finger protein, or transcription factor TZP (referring to Tudor and zinc finger domain containing protein), is a regulator of NF-kappaB activation by disrupting recruitment of PP2A to p65. It also functions as a transcription factor that binds Akt and plays a role in Akt cell survival/growth signaling. Moreover, it transcriptionally regulates p53. The phosphorylation of PHF20 on Ser291 mediated by protein kinase B (PKB) is essential in tumorigenesis via the regulation of p53 mediated signaling. PHF20 contains an N-terminal malignant brain tumor (MBT) domain, two Tudor domains, a plant homeodomain (PHD) finger and the putative DNA-binding domains, AT hook and Cys2His2-type zinc finger.
Links
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Statistics
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PSSM-Id: 277104
Aligned: 4 rows
Threshold Bit Score: 109.652
Created: 13-Aug-2013
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Zn binding siteputative
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C [CH] H [CH] C [CH]Click to see conserved feature residue pattern help
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          # #           #  #    #  #             #  #
Q9BVI0        654 RCICEVQEENDFMIQCEECQCWQHGVCMGLLEENVPEKYTCYVC 697  human
XP_002932906  728 RCMCEVQDENDFMIQCEECLCWQHGVCMGLLEDNVPEKYKCYIC 771  western clawed frog
NP_001004114  618 RCICEVQEENDFMIQCDECLCWQHGTCMGLYEDSVPDSYSCYIC 661  zebrafish
EMP41325      618 RCICEVEEENDFMIQCEECLCWQHGVCMGLLEDNVPEKYTCYIC 661  green seaturtle

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