2MIQ


Conserved Protein Domain Family
PHD1_Lid_like
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cd15605: PHD1_Lid_like 
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PHD finger 1 found in Drosophila melanogaster protein little imaginal discs (Lid) and similar proteins
Drosophila melanogaster Lid, also termed Retinoblastoma-binding protein 2 homolog, is identified genetically as a trithorax group (trxG) protein that is a Drosophila homolog of the human protein JARID1A/kdm5A, a member of the JARID subfamily within the JmjC proteins. Lid functions as a JmjC-dependent trimethyl histone H3K4 (H3K4me3) demethylase, which is required for dMyc-induced cell growth. It positively regulates Hox gene expression in S2 cells. Lid contains the catalytic JmjC domain, JmjN, the BRIGHT domain, which is an AT-rich interacting domain (ARID), and a Cys5HisCys2 zinc finger, as well as three plant homeodomain (PHD) fingers. This model corresponds to the first PHD finger of Lid.
Links
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Statistics
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PSSM-Id: 277078
Aligned: 6 rows
Threshold Bit Score: 89.4308
Created: 20-Mar-2014
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Zn binding siteputative
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C C H C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structure evidence that human KDM5D (2E6R) binds two Zn2+ ions through its first PHD finger
  • Comment:The PHD zinc finger is characterized as Cys4HisCys3.
  • Citation:PMID 7583761
  • Citation:PMID 7701562
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #  #           #  #    #  #              #  #
2MIQ_A         40 ICHICNRGDvEESMLLCDGCDDSYHTFCLLPPLTSIPKGEWLCPRC 85   fruit fly
EKC38036      289 ICHMCNRGDgEEYMLLCDGCDDAFHTYCLIPPMPEVPKGDWRCPKC 334  Pacific oyster
XP_002415325   57 VCHTCGRGDdEESMLLCDGCDDSYHTFCLLPPLQEIPRGDWRCPRC 102  black-legged tick
EFX69009      275 VCHNCGRGDaEEAMLLCDGCDDSYHTFCLNPPLNEIPKGDWRCPCC 320  common water flea
ELT96377      282 MCNLCGRGDgEESMLLCDSCDDAFHMHCLIPPLHEVPKGDWRCPKC 327  Capitella sp. I Grassle & Grassle, 1976
XP_006815984  327 VCHTCGKGNsEDFLLLCDGCDDSYHTFCLLPPLSQVPKGDWRCPKC 372  Saccoglossus kowalevskii

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