2JMI


Conserved Protein Domain Family
PHD_Yng1p_like
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cd15587: PHD_Yng1p_like 
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PHD finger found in yeast orthologs of ING tumor suppressor family
The yeast orthologs of the plant homeodomain (PHD) finger-containing ING tumor suppressor family consists of chromatin modification-related protein YNG1 (Yng1p), YNG2 (Yng2p), and transcriptional regulatory protein PHO23 (Pho23p). Yng1p, also termed ING1 homolog 1, is one of the components of the NuA3 histone acetyltransferase (HAT) complex. Its PHD finger binding to H3 Trimethylated at K4 (H3K4me3) promotes NuA3 H3 HAT activity at K14 of H3 on chromatin. Yng2p, also termed ESA1-associated factor 4, or ING1 homolog 2, is a subunit of the NuA4 HAT complex. It plays a critical role in intra-S-phase DNA damage response. Pho23p is part of the Rpd3/Sin3 histone deacetylase (HDAC) complex. It is required for the normal function of Rpd3 in the silencing of rDNA, telomeric, and mating-type loci. Yng1p and Pho23p inhibit p53-dependent transcription. In contrast, Yng2p has the opposite effect. All family members contain an N-terminal ING histone-binding domain and a C-terminal PHD finger.
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Statistics
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PSSM-Id: 277062
Aligned: 9 rows
Threshold Bit Score: 86.3149
Created: 24-Mar-2014
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Zn binding siteH3K4me3 binding
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C C H C C CClick to see conserved feature residue pattern help
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         # #          #    #     #  #              #   #  
2JMI_A        28 YCFCRNVSYGPMVACDNPACPFEWFHYGCVGLKQAPK--GKWYCsKDCKE 75  baker's yeast
EIE20485     183 YCYCRRVSFGEMVACDNPDCAVEWFHFECVSMTEQPK--GKWYC-RDCEA 229 Coccomyxa sp. C-169
XP_001780390 184 YCYCGQVSYGEMIACDNSECKIEWFHFDCVGIKERPK--GKWYC-SDCAV 230 Physcomitrella patens subsp. patens
XP_002963669 160 YCLCNQVSYGEMIACDNPDCKIEWFHFECAGVRERPK--GKWYC-PDCSQ 206 Selaginella moellendorffii
XP_004348916 249 FCHCRQISHGQMIACDDPYCRIEWFHYGCVGLTETPK--GKWYC-SDCLA 295 Capsaspora owczarzaki ATCC 30864
CCO66348     190 YCYCKRVSFGEMVGCENDKCKIEWFHFSCVGLDPTVKlkGKWYC-KECKL 238 Bathycoccus prasinos
EEY62407     230 YCSCRRVSFGQMVGCDNDDCKYEWFHFGCVGLADQPA--GKWYC-QDCKV 276 Phytophthora infestans T30-4
BAD89149     271 YCFCNRVSFGEMVGCENPDCKIEWFHFECVGLTSTPK--GKWYC-PDCTR 317 Dictyostelium discoideum
XP_004346006 173 YCICNRVSFGEMVGCDNPDCRVEWFHFECVGLTSPPK--GKWYC-NECSV 219 Acanthamoeba castellanii str. Neff

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