1X4I


Conserved Protein Domain Family
PHD_ING3
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cd15585: PHD_ING3 
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PHD finger found in inhibitor of growth protein 3 (ING3) and similar proteins
ING3, also termed p47ING3, is one member of the inhibitor of growth (ING) family of type II tumor suppressors. It is ubiquitously expressed and has been implicated in transcription modulation, cell cycle control, and the induction of apoptosis. It is an important subunit of human NuA4 histone acetyltransferase complex, which regulates the acetylation of histones H2A and H4. Moreover, ING3 promotes ultraviolet (UV)-induced apoptosis through the Fas/caspase-8-dependent pathway in melanoma cells. It physically interacts with subunits of E3 ligase Skp1-Cullin-F-boxprotein complex (SCF complex) and is degraded by the SCF (F-box protein S-phase kinase-associated protein 2, Skp2)-mediated ubiquitin-proteasome system. It also acts as a suppression factor during tumorigenesis and progression of hepatocellular carcinoma (HCC). ING3 contains an N-terminal ING domain and a C-terminal plant homeodomain (PHD) finger.
Links
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Statistics
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PSSM-Id: 277060
Aligned: 15 rows
Threshold Bit Score: 90.2036
Created: 12-Aug-2013
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Zn binding siteH3K4me3 binding
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C C H C C CClick to see conserved feature residue pattern help
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         # #          #    #     #  #            #  #
1X4I_A         8 YCICNQVSYGEMVGCDNQDCPIEWFHYGCVGLTEAPKGKWYCPQC 52  human
NP_957231    360 YCICNQVSYGEMVGCDNQDCPIEWFHYGCVGLTEAPKGKWYCPQC 404 zebrafish
EKC28242     343 YCLCNQVSYGDMVGCDNDDCPIEWFHYGCVGLTQAPKGKWFCPQC 387 Pacific oyster
XP_002126978 346 YCLCNQVSYGEMVGCDNDKCPIEWFHYGCVGLEQAPTGKWFCPQC 390 Ciona intestinalis
XP_003729881  83 YCLCNQVSYGEMVGCDNPKCPIEWFHYGCVGITNPPKGKWFCPQC 127 purple urchin
XP_003384635 260 YCLCNQVSYGEMICCDNPTCSIEWFHYGCVGIAEAPKGKWFCPQC 304 Amphimedon queenslandica
XP_002161789 392 YCLCNQVSYGEMVGCDNSACPVEWFHYGCVGLTDAPKGKWYCPDC 436 green hydra
XP_002108193 296 YCICNQISYGEMVGCDNDDCPIEWFHYACVGISEPPKGKWYCPQC 340 Trichoplax adhaerens
XP_002599728  12 YCICNQVSYGDMVGCDNEDCPIEWFHYGCVGISEPPKGKWYCPQC 56  Florida lancelet
XP_002434464 364 YCICNQVSYGDMVACDNDDCPFEWFHYPCVGISQPPKGKWFCPQC 408 black-legged tick

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