Conserved Protein Domain Family
PHD_ash2p_like

cd15583: PHD_ash2p_like

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PHD finger found in Schizosaccharomyces pombe Set1 complex component ash2 (spAsh2p) and similar proteins

spAsh2p, also termed Set1C component ash2, or COMPASS component ash2, or complex proteins associated with set1 protein ash2, or Lid2 complex component ash2, or Lid2C component ash2, is orthologous to Drosophila melanogaster Ash2 protein. Both spAsh2p and D. melanogaster Ash2 contain a plant homeodomain (PHD) finger and a SPRY domain. In contrast, its counterpart in Saccharomyces cerevisiae, Bre2p, has no PHD finger and is not included in this family. spAsh2p shows histone H3 Lys4 (H3K4) methyltransferase activity through its PHD finger. It also interacts with Lid2p in S. pombe. Human Ash2L contains an atypical PHD finger that lacks part of the Cys4HisCys3 signature characteristic of PHD fingers, it binds to only one zinc ion through the second half of the motif and does not have histone tail binding activity.

Links

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Source:	cd15489
Taxonomy:	Opisthokonta
PubMed:	1 link

Protein:	Representatives
	Specific Protein
	Related Protein
	Related Structure
	Architectures
Superfamily:	cl22851

Statistics

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PSSM-Id:	277058
Aligned:	13 rows
Threshold Bit Score:	82.0121
Created:	10-Sep-2013
Updated:	2-Oct-2020

Structure

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Conserved Features/Sites?
PubMed References ?

Zn binding siteputative

Conserved site includes 8 residues -Click on image for an interactive view with Cn3D

Feature 1: Zn binding site [ion binding site], 8 residue positions

Conserved feature residue pattern:C C C [CH] H [CH] C [CH]

Click to see conserved feature residue pattern help

Evidence:

Comment:Based on the structures of human Ash2L PHD1 bound with a zinc ion and with other PHD fingers having two zinc ions bound. Note that the human Ash2L PHD finger lacks part of the conserved Cys4HisCys3 signature that mediates the coordination of the two zinc ions.
Structure:3RSN: Human Ash2l PHD finger binds a zinc ion; contacts at 4A
Citation:PMID 21660059
Citation:PMID 21642971
Citation:PMID 11124022
Citation:PMID 15964836
Citation:PMID 23907177
Citation:PMID 24554700
Citation:PMID 17687328
Comment:The PHD zinc finger is characterized as Cys4HisCys3.
Citation:PMID 7583761
Citation:PMID 7701562
Citation:PMID 21514168

Scroll to Sequence Alignment Display

Sequence Alignment

include consensus sequence

Format: Row Display: Color Bits: Type Selection:

Feature 1         # #              #  #    #  #                       #  #
3RSN_A         7 SVDEENGRql--geVELQCGICTKWFTADTFGIDTSScl-----pFXTNYSFHCNVC 56   human
XP_005092518  21 GCYCGEKRkl--gtPEFQCINCGTWFHGSCVNAEPGKcl-----pFMISYQFHCKRC 70   California sea hare
XP_002115146  29 KCYCGLERlkdgttVEFQCVDCRCWFHAKCTEFTSDKli-----pYLTNYEYLCKRC 80   Trichoplax adhaerens
CCG81778     292 YCYCGDDRnl--ldVDVQCTKCSNFFHGRCIGIDMGPvv-----pFMTNYEFVCKNC 341  Taphrina deformans PYCC 5710
ESA02312      18 YCYCGKDRnl--teVSLQCSGCLNWFHAKCTKISIDTni-----pIFTNYKFTCKWC 67   Rhizophagus irregularis DAOM 181602
ESO89813      44 PCYCEKPRvi--gsPEIQCSICLRWFHVDCVNANFNGac----lpFITNYQFCCKLC 94   owl limpet
ESN99523      37 TCYCGRDRnl--niCEFQCGMCLRYYHETCVSCYNRDcv-----pFMTNYQFFCKRC 86   Helobdella robusta
NP_496553     21 VCYCDGKRel--gsVEVVCSTCLKWFHGRCLKEFHEFsrnsngvpFMICYTFTCKQC 75   Caenorhabditis elegans
AAC47328      36 VCYCGKERnl--niVELLCATCSRWVHETCVSYQLGKgkl---lpFITNYVFVCKNC 87   fruit fly
XP_789737    252 DCYCGEGRny--edVELQCNQCFKWFHKACITTVNVVnt----lpYMTTYTFCCKNC 302  purple urchin
XP_003742872  45 QCYCGTERil--gkMEMQCVGCYRWFHEKCLSISIPRcv-----pFMMNYAFICKKC 94   western predatory mite
3S32_A        12 SVDEENGRql--geVELQCGICTKWFTADTFGIDTSScl-----pFXTNYSFHCNVC 61   human
O60070        42 YCYCGKDRnl--rfPDLQCSVCLNMFHLSCLSPPCTSmm-----gFSTNYQFVCKHC 91   Schizosaccharomyces pombe 972h-

Citing CDD

Jiyao W et al.(2023). "The conserved domain database in 2023.", Nucleic Acids Res. 51(D1):D384-D388.

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