Conserved Protein Domain Family
PHD_JMJD2A
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cd15575: PHD_JMJD2A 
PHD finger found in Jumonji domain-containing protein 2A (JMJD2A)
JMJD2A, also termed lysine-specific demethylase 4A (KDM4A), or JmjC domain-containing histone demethylation protein 3A (JHDM3A), catalyzes the demethylation of di- and trimethylated H3K9 and H3K36. It is involved in carcinogenesis and functions as a transcription regulator that may either stimulate or repress gene transcription. It associates with nuclear receptor co-repressor complex or histone deacetylases. Moreover, JMJD2A forms complexes with both the androgen and estrogen receptor (ER) and plays an essential role in growth of both ER-positive and -negative breast tumors. It is also involved in prostate, colon, and lung cancer progression. JMJD2A contains jmjN and jmjC domains in the N-terminal region, followed by a canonical Cys4HisCys3 PHD finger, a non-canonical extended PHD (ePHD) finger, Cys2HisCys5HisCys2His, and a Tudor domain. This model corresponds to the canonical Cys4HisCys3 PHD finger.
Links
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Statistics
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PSSM-Id: 277050
Aligned: 4 rows
Threshold Bit Score: 190.499
Created: 7-Aug-2013
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Zn binding siteputative
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C [CH] H [CH] C [CH]Click to see conserved feature residue pattern help
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #  #                                                                     #  #  
O75164        667 HCAVCMIFQTYhqvefggfnqnc---gnasdlapqkqRTKPLIPEMCFTSTGCSTDINLSTPYLEEDGTSILVSCKKCSV 743  human
EMP34170     2434 HCAVCMLFQTYqvecgghgqss----gvaastatrkvRTKPLIPEMCFTATGCSTDLNLSTPYLEEDGTSVLITCKNCSV 2509 green seaturtle
NP_001107498  612 HCTVCMLFKAYyqpecvgenni-----sdpssvgfhlKTKPLIPEMCFTTTGTNTEINLSAPFLEDDGTSILITCKSCCV 686  western clawe...
XP_007885251  640 YCSICALFQSYqvdcweghnsssstkpvgagepriekKTKPLVPEMCFTSGGDNSDLSLATSYIEEDGTSALVTCAKCCV 719  elephant shark

Feature 1           #  #             #  #
O75164        744 RVHASCYGVPpakasEDWMCSRC 766  human
EMP34170     2510 CVHASCYGVSpdkatEDWMCSRC 2532 green seaturtle
NP_001107498  687 CVHASCYGVSkekavEGWLCSRC 709  western clawed frog
XP_007885251  720 CVHASCYGVApekvaDDWMCVRC 742  elephant shark

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