2KU3


Conserved Protein Domain Family
PHD_BRPF
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cd15572: PHD_BRPF 
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PHD finger found in bromodomain and PHD finger-containing (BRPF) proteins
The family of BRPF proteins includes BRPF1, BRD1/BRPF2, and BRPF3. They are scaffold proteins that form monocytic leukemic zinc-finger protein (MOZ)/MOZ-related factor (MORF) H3 histone acetyltransferase (HAT) complexes with other regulatory subunits, such as inhibitor of growth 5 (ING5) and Esa1-associated factor 6 ortholog (EAF6). BRPF proteins have multiple domains, including a canonical Cys4HisCys3 plant homeodomain (PHD) zinc finger followed by a non-canonical extended PHD (ePHD) finger, Cys2HisCys5HisCys2His, a bromodomain and a proline-tryptophan-tryptophan-proline (PWWP) domain. PHD and ePHD fingers both bind to lysine 4 of histone H3 (K4H3), bromodomains interact with acetylated lysines on N-terminal tails of histones and other proteins, and PWWP domains show histone-binding and chromatin association properties. This model corresponds to the canonical Cys4HisCys3 PHD finger.
Links
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Statistics
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PSSM-Id: 277047
Aligned: 7 rows
Threshold Bit Score: 96.146
Created: 7-Aug-2013
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Zn binding siteputative
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C C H C C CClick to see conserved feature residue pattern help
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1            #  #             #  #    #  #            #  #      
2KU3_A         16 DAVCSICMDGESqNSNVILFCDmCNLAVHQECYGVPYIPEGQWLCRHCLQSRAR 69   human
Q9ULD4        212 DAFCCVCLDDEChNSNVILFCDiCNLAVHQECYGVPYIPEGQWLCRCCLQSPSR 265  human
P55201        273 DAVCCICNDGECqNSNVILFCDmCNLAVHQECYGVPYIPEGQWLCRRCLQSPSR 326  human
EFX75273      250 DAECCICMDGECqNSNVILFCDmCNLAVHQECYGVPYIPEGQWLCRRCLQSPSR 303  common water flea
NP_610266     283 DAVCCICLDGECqNTNVILFCDmCNLAVHQDCYGVPYIPEGQWLCRRCLQSPSK 336  fruit fly
XP_003744983  451 DAVCCICQDGEChNANAILFCDmCNLAVHQECYGVPYIPEGQWLCRRCLQSPSK 504  western predatory mite
XP_003383026  297 NAVCCICNDGEChNTNAILFCDmCNLAVHQECYGVPYIPEGQWLCRRCLQSPSR 350  Amphimedon queenslandica

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