2JWO


Conserved Protein Domain Family
PHD_RAG2
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cd15569: PHD_RAG2 
Click on image for an interactive view with Cn3D
PHD finger found in V(D)J recombination-activating protein 2 (RAG-2) and similar proteins
RAG-2 is an essential component of the lymphoid-specific recombination activating gene RAG1/2 V(D)J recombinase mediating antigen-receptor gene assembly. It contains an acidic hinge region implicated in histone-binding, a non-canonical plant homeodomain (PHD) finger followed by a C-terminal extension of 40 amino acids that is essential for phosphoinositide (PtdIns)-binding. The PHD finger is a chromatin-binding module that specifically recognizes histone H3 trimethylated at lysine 4 (H3K4me3) and influences V(D)J recombination.
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Statistics
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PSSM-Id: 277044
Aligned: 5 rows
Threshold Bit Score: 134.655
Created: 22-Dec-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Zn binding siteputative
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H H C C HClick to see conserved feature residue pattern help
Evidence:
  • Structure:2JWO; Mus musculus RAG2-PHD binds two Zn2+ ions
  • Comment:The PHD zinc finger is typically characterized as Cys4HisCys3, for the RAG2 PHD finger the motif is Cys3His2Cys2His.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         #   #                      #      #  #  #                   #  #
2JWO_A     10 YWITCCPTCDVDiNTWVPFYSTELNKPAMIYCSHg-dGHWVHAQCMDLeERTLIHLSEgsnKYYCNEH 76  house mouse
O13034    415 YWIKCCLSCQVDpNIWEPYYSTELTRPAMIFCSRgegGHWVHAQCMELpESLLLQLSQdnsKYFCLDH 482 zebrafish
P25022    416 YWIICCASCNIDiNTWVPFYSTELNKPAMILCSSg-sGHWVHAQCMDLsESMLLQLSEanvKYFCNEH 482 chicken
Q91830    408 YWIKCCPDCDMDrNTWEPFYSTELNKPSMIFCSKd-gGHWVHSQCMDLsETMLKYLSQnniKYFCNEH 474 African clawed frog
P55895    415 YWITCCPTCDVDiNTWVPFYSTELNKPAMIYCSHg-dGHWVHAQCMDLaERTLIHLSAgsnKYYCNEH 481 human

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