Conserved Protein Domain Family
PHD3_PHF14
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cd15563: PHD3_PHF14 
PHD finger 3 found in PHD finger protein 14 (PHF14) and similar proteins
PHF14 is a novel nuclear transcription factor that controls the proliferation of mesenchymal cells by directly repressing platelet-derived growth factor receptor-alpha (PDGFRalpha) expression. It also acts as an epigenetic regulator and plays an important role in the development of multiple organs in mammals. PHF14 contains three canonical plant homeodomain (PHD) fingers and a non-canonical extended PHD (ePHD) finger, Cys2HisCys5HisCys2His. It can interact with histones through its PHD fingers. The model corresponds to the third PHD finger.
Links
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Statistics
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PSSM-Id: 277038
Aligned: 12 rows
Threshold Bit Score: 75.5081
Created: 13-Aug-2013
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Zn binding siteputative
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C [CH] H [CH] C [CH]Click to see conserved feature residue pattern help
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         #  #           #  #    #   #                 #  #
EAW93636     870 ECATCKGTGdnENLVRCDECRLCYHFg-CLDPPLKKSPKqtGYGWICQEC 918  human
NP_001012874 824 ECATCKGTGdnENLVRCDECRLCYHFg-CLDPPLKKSPKqtGYGWICQEC 872  chicken
AAI24678     430 ECTTCKGPGdnENLVRCDECRLCYHFg-CLDPPLKKSPKqtGYGWICQEC 478  zebrafish
AAL39608     720 SCCVCSQTGksNQVVTCDECHRHYHFa-CLDPPLKKSPKirGYSWHCADC 768  fruit fly
NP_001135681 869 ECAVCKGTGdnENLVRCDECTLCYHFg-CLDPPLKKSPKqtGYGWICQEC 917  western clawed frog
ELU07972     754 DCCVCNESGdnGCLVRCDECSLCFHFr-CLDPPCKKSPKvrGYGWVCSVC 802  Capitella sp. I Grassle & Grassle, 1976
EFX89034     756 VCSACSRNGikSDTVSCDECQRVFHFg-CLDPPLKKTPKqrGYSWHCAEC 804  common water flea
EKC22096     331 TCAVCNQSGdsSDMVKCDECMLCYHFg-CLDPPMKKTPKqrGYSWHCEAC 379  Pacific oyster
XP_002603950 477 ECCVCWQTGdnACLVRCDDCQLCFHFa-CLDPPLTRSPKcfGYGWVCQNC 525  Florida lancelet
XP_001635855 154 QCSQCDSPGdnTTLVRCDNCKLCYHFg-CLDPPVKSNPKkrGYMWYCTEC 202  starlet sea anemone
XP_002168113 681 NCFKCKKNGdaSSLVKCDNCKRCYHFkiCLDPPYAKSPKgkFWDWVCEEC 730  green hydra
XP_003741163  40 HCVKCESSDt-NQIVVCDECNRGIHWs-CLEPPVKKNPKprGYTWTCEEC 87   western predatory mite

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