Conserved Protein Domain Family
PHD2_PHF14
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cd15562: PHD2_PHF14 
PHD finger 2 found in PHD finger protein 14 (PHF14) and similar proteins
PHF14 is a novel nuclear transcription factor that controls the proliferation of mesenchymal cells by directly repressing platelet-derived growth factor receptor-alpha (PDGFRalpha) expression. It also acts as an epigenetic regulator and plays an important role in the development of multiple organs in mammals. PHF14 contains three canonical plant homeodomain (PHD) fingers and a non-canonical extended PHD (ePHD) finger, Cys2HisCys5HisCys2His. It can interact with histones through its PHD fingers. The model corresponds to the second PHD finger.
Links
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Statistics
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PSSM-Id: 277037
Aligned: 16 rows
Threshold Bit Score: 92.8542
Created: 13-Aug-2013
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Zn binding siteputative
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C [CH] H [CH] C [CH]Click to see conserved feature residue pattern help
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         #  #           #  #    #  #                  #  #
O94880       727 SCGICKKnhDQHLLLLCDTCKLHYHLGCLDPPLTRMPRKtkNSYWQCSEC 776 human
XP_002603950 367 QCGICKQtsDQHLLAKCDTCRLFYHLGCLDPPLTRMPKKtaTIGWQCSEC 416 Florida lancelet
XP_003383240 521 MCCICKGcnDDHLMAQCDTCSLYYHINCLDPPLTRVPLKtsRQGWQCEDC 570 Amphimedon queenslandica
CCD75914     292 ECMICHGlqDQHLITSCDTCGKAFHLACLDPPLLRMPKRskLYGWQCSFC 341 Schistosoma mansoni
XP_790990    569 LCGLCEQshDQHLLVLCDICKKYYHMGCLEPPLTRLPKKsaFSVWQCSEC 618 purple urchin
EJD74461     565 FCDECKKmtEQHLMTQCDKCHKYYHLACLDPPLLKMPKKtsTQGWMCSLC 614 Loa loa
EKC22096     185 KCALCHKtnSQHQLAHCDSCKEYYHLGCLDPPLTRMPKKtkIMGWQCSEC 234 Pacific oyster
ELU07972     582 SCGLCAQtnDQHLLAKCDKCRLHYHLGCLDPPLSRMPKKtkQFGWQCSEC 631 Capitella sp. I Grassle & Grassle, 1976
XP_001635855   4 SCATCKStdNQHLMAECDTCHNFYHLACVDPPLSRMPRKsaKCLWQCSEC 53  starlet sea anemone
CDJ81295     542 VCKECGKasDQHLMIACDSCYEYYHIGCLDPPLEKVPKKv-NCEWHCADC 590 barber pole worm

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