Conserved Protein Domain Family
PHD1_PHF14
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cd15561: PHD1_PHF14 
PHD finger 1 found in PHD finger protein 14 (PHF14) and similar proteins
PHF14 is a novel nuclear transcription factor that controls the proliferation of mesenchymal cells by directly repressing platelet-derived growth factor receptor-alpha (PDGFRalpha) expression. It also acts as an epigenetic regulator and plays an important role in the development of multiple organs in mammals. PHF14 contains three canonical plant homeodomain (PHD) fingers and a non-canonical extended PHD (ePHD) finger, Cys2HisCys5HisCys2His. It can interact with histones through its PHD fingers. The model corresponds to the first PHD finger.
Links
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Statistics
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PSSM-Id: 277036
Aligned: 15 rows
Threshold Bit Score: 77.8631
Created: 7-Aug-2013
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Zn binding siteputative
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C [CH] H [CH] C [CH]Click to see conserved feature residue pattern help
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #  #                  #  #    #  #                       #  #
O94880        321 ICCVCLGDnse-----daDEIIQCDNCGITVHEGCYgvdgesdsimssasenSTEPWFCDAC 377  human
NP_608836     120 MCCVCLGErsd-----dvNEIVECDSCGVSVHEGCYgvsdnvsi-sstnstcSTEPWFCEAC 175  fruit fly
ELU07972      152 VCCVCLGDssnsclsgeaNEIVECDGCQINVHEGCYgitesqsv-astissaSTEPWFCDSC 212  Capitella sp. I Grassle & Grass...
EFX89034      136 VCCICLGThss-----dvNEVVECDSCGILVHEGCYgvtesgsv-sstasscSTEPWFCEPC 191  common water flea
XP_002110130  111 ICLICLSNse------dsGEIIECDKCGISVHEGCYgvedesv--ldddpteTTEPWFCDCC 164  Trichoplax adhaerens
GAA30023      171 VCMVCLGDgnd-----pnDELIECDGCGIVVHEDCYkvvdsifm-ssgasssSTDAWFCEPC 226  Clonorchis sinensis
XP_002168113  132 VCGICLESken-----dnDEILECDNCGISVHEGCYgdigaddn-dtidsdvEVEPWFCEPC 187  green hydra
EJD74461      117 ICTLCLNQrav----vrnDEVIQCDKCGVAVHENCYitenvgds-esdgsssSTEPWFCEAC 173  Loa loa
NP_507508     107 ICGVCINQrni----vaaGDFLQCQKCGINVHESCYgtlp---------ggsDDASWYCEPC 155  nematode
ESO94133      170 ICCVCLTDvtg-----adDEIVECDNCGVPVHEGCYgisdnqsa-astessaSTEPWFCDAC 225  owl limpet

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