2M85


Conserved Protein Domain Family
PHD_SHPRH
?
cd15547: PHD_SHPRH 
Click on image for an interactive view with Cn3D
PHD finger found in E3 ubiquitin-protein ligase SHPRH
SHPRH, also termed SNF2, histone-linker, PHD and RING finger domain-containing helicase, belongs to the SWI2/SNF2 family of ATP-dependent chromatin remodeling enzymes, containing the Cys3HisCys4 RING-finger characteristic of E3 ubiquitin ligases. It plays a key role in the error-free branch of DNA damage tolerance. As functional homologs of Saccharomyces cerevisiae Rad5, SHPRH and its closely-related protein, helicase like transcription factor (HLTF), act as ubiquitin ligases that cooperatively mediate Ubc13-Mms2-dependent polyubiquitination of proliferating cell nuclear antigen (PCNA) and maintain genomic stability. SHPRH contains a SNF2 domain, a H1.5 (linker histone H1 and H5) domain, a plant homeodomain (PHD) finger, a Cys3HisCys4 RING-finger, and a C-terminal helicase domain.
Links
?
Statistics
?
PSSM-Id: 277022
Aligned: 11 rows
Threshold Bit Score: 65.8948
Created: 12-Aug-2013
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
Zn binding siteputative
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C C H C C CClick to see conserved feature residue pattern help
Evidence:
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1          #  #                        #  #    #  #                   #  #
2M85_A         17 EC-ICGELdqi-----------drKPRVQCLKCHLWQHAKCVNYd--eKNLKi---kPFYCPHC 63   human
XP_419651     671 EC-ICGELglv-----------dyKARVQCLKCHLWQHAECVNYk--eENLKi---kPFYCPHC 717  chicken
CAG13193      620 EC-ICGELgii-----------dyKARVQCMNCQLWQHASCVNYk--eESLDt---tPFYCPHC 666  spotted green pufferfish
XP_004914950  622 EC-ICGELgly-----------dyKARVQCLQCHLWQHAECVNYk--qENLGv---tPFYCPHC 668  western clawed frog
XP_002604289  592 EC-ICGVTdah----------vdsRTRLQCWQCGNWQHAECVNYnatsESDPakmaePYHCPHC 644  Florida lancelet
EKC34780      715 EC-ICGVSseargt----snsrkkKHRVQCVMCGLYQHAECVGYd--lENPYr---gQFKCPHC 768  Pacific oyster
XP_005088907  714 EC-NCGQLeneae------tsrrgLHTVSCLQCGMSQHAECMNYd---LTDPlr--gDYLCPHC 765  California sea hare
XP_003201203  208 VCgTCGQRdd------------snRLTISCKSCGAFRHVDCVGIf---ETWKn---eEYMCPPC 253  zebrafish
ESO03203       77 DC-SCGKMfkqhkvghknarldlnKIIVSCEKCGSCQHAGCVGYdltdESRG-----SYLCPHC 134  Helobdella robusta
ELU00238      507 EC-VCGNKrn------------qqDSLIECTKCQSHQHPKCMNYd--tESKHr---dPYLCPHC 552  Capitella sp. I Grassle & Gra...
EDV27774      420 TC-ICGGLnede--------dseqPKTAQCQICSIWQHPKCVRP----DFDYc---sEYICPHC 467  Trichoplax adhaerens

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap