3O7A


Conserved Protein Domain Family
PHD_PHF13_like
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cd15546: PHD_PHF13_like 
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PHD finger found in PHD finger proteins PHF13 and PHF23
PHF13, also termed survival time-associated PHD finger protein in ovarian cancer 1 (SPOC1), is a novel plant homeodomain (PHD) finger-containing protein that shows strong expression in spermatogonia and ovarian cancer cells, modulates chromatin structure and mitotic chromosome condensation, and is important for proper cell division. It is also required for spermatogonial stem cell differentiation and sustained spermatogenesis. The overexpression of PHF13 associates with unresectable carcinomas and shorter survival in ovarian cancer. PHF23, also termed PHD-containing protein JUNE-1, is a hypothetical protein with a PHD finger. It is encoded by gene PHF23 that acts as a candidate fusion partner for the nucleoporin gene NUP98. The NUP98-PHF23 fusion results from a cryptic translocation t(11;17)(p15;p13) in acute myeloid leukemia (AML).
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Statistics
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PSSM-Id: 277021
Aligned: 11 rows
Threshold Bit Score: 78.6392
Created: 12-Aug-2013
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Zn binding sitehistone H3
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C C H C C CClick to see conserved feature residue pattern help
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         # #           #  #    #  #             #  #
3O7A_A         6 TCFCMKPFAGRPMIECNECHTWIHLSCAKIRKSNVPEVFVCQKC 49  human
Q9BUL5       341 TCYCRKPFAGRPMIECSLCGTWIHLSCAKIKKTNVPDFFYCQKC 384 human
CBY33494     582 TCFCGAPFAGRPMIECDNCSLWVHMTCGKVRKNYVPAKYVCPLC 625 Oikopleura dioica
EFX77123     109 TCYCGKPFAGRPMIECSHCLTWIHLSCARIRRTNIPDEFICAKC 152 common water flea
XP_001624091  88 TCYCCKPFAGRPMIECSECLTWIHLSCAKIRRSNVPDTFICQKC 131 starlet sea anemone
EFA11472     103 TCFCGKPFAGRPMIECLECLTWIHLSCARIKKNNIPEVFLCATC 146 red flour beetle
XP_002402063 115 TCFCLKPFAGRPMIECSECLTWIHLSCAKIRRNNIPEEFTCQRC 158 black-legged tick
EKC24375      67 TCFCMKPYAGRPMIECSECETWIHFSCAKIRKNNVPEVYTCQLC 110 Pacific oyster
XP_002736653 123 TCYCSKPFAGRPMIECNECNTWIHLSCAKIRKSNIPDTFVCQQC 166 Saccoglossus kowalevskii
XP_785537    115 TCFCNKPFAGRPMIECNECETWVHLSCAKIRKTNVPEIFICTHC 158 purple urchin
XP_002592146 253 TCFCQKPFAGRPMIECTECTIWIHLSCAKIRKSNVPEIFICQRC 296 Florida lancelet

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