Conserved Protein Domain Family
PHD_RSF1
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cd15543: PHD_RSF1 
PHD finger found in Remodeling and spacing factor 1 (Rsf-1)
Rsf-1, also termed HBV pX-associated protein 8, or Hepatitis B virus X-associated protein alpha (HBxAPalpha), or p325 subunit of RSF chromatin-remodeling complex, is a novel nuclear protein with histone chaperon function. It is a subunit of an ISWI chromatin remodeling complex, remodeling and spacing factor (RSF), and plays a role in mediating ATPase-dependent chromatin remodeling and conferring tumor aggressiveness in common carcinomas. As an ataxia-telangiectasia mutated (ATM)-dependent chromatin remodeler, Rsf-1 facilitates DNA damage checkpoints and homologous recombination repair. It regulates the mitotic spindle checkpoint and chromosome instability through the association with serine/threonine kinase BubR1 (BubR1) and Hepatitis B virus (HBV) X protein (HBx) in the chromatin fraction during mitosis. It also interacts with cyclin E1 and promotes tumor development. Rsf-1 contains a plant homeodomain (PHD) finger.
Links
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Statistics
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PSSM-Id: 277018
Aligned: 19 rows
Threshold Bit Score: 67.2944
Created: 12-Aug-2013
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Zn binding siteputative
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C [CH] H [CH] C [CH]Click to see conserved feature residue pattern help
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                           #  #             #    #    #  #              #  #
Q96T23                         893 PCKKCGLpn--hPELILLCDs--CDSGYHTACLRPPLmiIPDGEWFCPPC 938  human
GAA41280                       452 PCQVCFRch--lPEWMLLCDr--CDLGHHAMCLRPPLliIPEGDWFCPRC 497  Clonorchis sinensis
XP_003741795                   805 PCRKCNKsd--hPEFILLCDs--CDAGYHMSCLKPALmvIPLGNWYCPPC 850  western predatory mite
NP_610101                     1372 ACQKCGKsd--hPEWILLCDtptCNKGYHCSCLSPVLfyIPEGDWHCPPC 1419 fruit fly
XP_002108405                   266 PCTACFSca--sPATILLCDs--CNAGYHMSCLRPPLfvIPDGNFYCPFC 311  Trichoplax adhaerens
EPQ30447                       505 MCEICFRge--dGINMLLCDe--CNRGYHMYCLQPPLtaIPKSQWFCPSC 550  Pseudozyma flocculosa PF-1
ETP05278                      3434 LCRQCGQmn--aQESMLLCDs--CDAAYHAFCLQPPLssIPPGNWYCPRC 3479 Phytophthora parasitica CJ...
NP_536734                     1064 LCKVCRRgs--dPEKMLLCDe--CNAGTHMFCLKPKLrsVPPGNWYCNDC 1109 fruit fly
XP_005538817                   520 YCRRCKGme--dPHLMLLCDr--CDDCFHTYCCRPPLdqVPQKDWFCEKC 565  Cyanidioschyzon merolae st...
WGS:AAGF:cds.TTHERM_00538850A  348 PCSICDGnteddDDKLLLCDr--CNNGFHIFCLKPPLteIPEEQWFCADC 395  Tetrahymena thermophila SB210

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