2KFT,1XWH,2KE1


Conserved Protein Domain Family
PHD1_AIRE
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cd15539: PHD1_AIRE 
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PHD finger 1 found in autoimmune regulator (AIRE)
AIRE, also termed autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED) protein, functions as a regulator of gene transcription in the thymus. It is essential for prevention of autoimmunity. AIRE plays a critical role in the induction of central tolerance. It promotes self-tolerance through tissue-specific antigen (TSA) expression. It also acts as an active regulator of chondrocyte differentiation. AIRE contains a homogeneously-staining region (HSR) or caspase-recruitment domain (CARD), a nuclear localization signal (NLS), a SAND (for Sp100, AIRE, nuclear phosphoprotein 41/75 or NucP41/75, and deformed epidermal auto regulatory factor 1 or Deaf1) domain, two plant homeodomain (PHD) fingers, and four LXXLL (where L stands for leucine) motifs. This model corresponds to the first PHD finger that recognizes the unmethylated tail of histone H3 and targets AIRE-dependent genes.
Links
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Statistics
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PSSM-Id: 277014
Aligned: 12 rows
Threshold Bit Score: 69.4018
Created: 13-Aug-2013
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Zn binding sitehistone H3
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C C H C C CClick to see conserved feature residue pattern help
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #  #        #  #    #  #                #  #
2KFT_A          7 ECAVCRDGGELICCDGCPRAFHLACLSPPlr--eIPSGTWRCSSC 49   human
1XWH_A         10 ECAVCRDGGELICCDGCPRAFHLACLSPPlr--eIPSGTWRCSSC 52   human
2KE1_A         10 ECAVCRDGGELICCDGCPRAFHLACLSPPlr--eIPSGTWRCSSC 52   human
ABW08121       31 ECSVCRDGGELICCDGCPRSFHLSCLVPPlt--hIPSGTWRCDAC 73   African clawed frog
ABW24496      216 ECAVCGDGGELICCDGCPRAFHLPCLVPPlp--rVPSGTWQCSSC 258  chicken
NP_001103484  294 ECAVCKDGGELICCDGCPRAFHLSCLVPPlt--sIPRGTWRCQLC 336  zebrafish
EPS71022      443 MCAVCGAGGELVICNGCPRAFHAACLGIQs----SPGDDWQCSHC 483  Genlisea aurea
EQC40453     1035 YCNDCGAGGTLLLCDGCPKAFHAACLQLDed-dlSPGEDWFCSEC 1078 Saprolegnia diclina VS20
ETI33243      150 HCELCATGGSLLCCDGCPRAYHVSCAQPPit-rlDKEEDWFCSHC 193  Phytophthora parasitica P1569
EXX73755       29 HCDVCTYGGRMMCCDGCPKAFHFTCLVPPldvdnPPTGNWYCREC 73   Rhizophagus irregularis DAOM 197198w
Q9ZQA2        579 LCVICADGGNLLLCDSCPRAFHIECVSLPs----IPRGNWHCKYC 619  thale cress
O80922        466 MCSICGDGGDLLLCAGCPQAFHTACLKFQs----MPEGTWYCSSC 506  thale cress

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