4COS


Conserved Protein Domain Family
PHD_PRKCBP1
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cd15538: PHD_PRKCBP1 
Click on image for an interactive view with Cn3D
PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)
PRKCBP1, also termed cutaneous T-cell lymphoma-associated antigen se14-3 (CTCL-associated antigen se14-3), or Rack7, or zinc finger MYND domain-containing protein 8 (ZMYND8), is a novel receptor for activated C-kinase (RACK)-like protein that may play an important role in the activation and regulation of PKC-beta I, and the PKC signaling cascade. It also has been identified as a formin homology-2-domain containing protein 1 (FHOD1)-binding protein that may be involved in FHOD1-regulated actin polymerization and transcription. Moreover, PRKCBP1 may function as a REST co-repressor 2 (RCOR2) interacting factor; the RCOR2/ZMYND8 complex which might be involved in the regulation of neural differentiation. PRKCBP1 contains a plant homeodomain (PHD) finger, a bromodomain, and a proline-tryptophan-tryptophan-proline (PWWP) domain.
Links
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Statistics
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PSSM-Id: 277013
Aligned: 25 rows
Threshold Bit Score: 62.7292
Created: 14-Aug-2013
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Zn binding siteputative
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C C H C C CClick to see conserved feature residue pattern help
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #  #         #  #    #  #               #  #
4COS_A         10 YCWVCHRe-GQVLCCELCPRVYHAKCLRltse---pegDWFCPEC 50   human
XP_002423637  196 FCWTCHKd-GSVVKCDTCPRVFHLKCVSlskd---pskNWICPEC 236  human body louse
XP_001625954   49 YCWRCHRp-GEVILCDFCPRVFHKRCVRdgam---sasKWRCPSC 89   starlet sea anemone
XP_004209767  105 YCWVCHRe-GEVCLCSSCPRVIHKKCAEsise--dldeNFVCYCC 146  green hydra
EFZ13980      164 FCWRCHKe-KVDAYCTACPRSWHRKCIGgtps---sleKWICGEC 204  red fire ant
NP_651881     345 FCWKCRGc-GKLMPCSKCLRSFHSYCVRpatt--kfdsSWKCPEC 386  fruit fly
XP_311907     234 FCWRCKSk-DPDLGCSKCIRSYHKLCVRytv----dnpNWSCTEC 273  Anopheles gambiae str. PEST
XP_004517921  491 FCWKCREc-VDLFPCSKCVRCFHCTCIKvtsat-klddTWVCPEC 533  Mediterranean fruit fly
XP_005191534  463 FCWKCHDa-AVDISCNKCIRSFHTTCVKaki-----dsSWICTEC 501  house fly
EAT38185      291 FCWRCKTcePGLETCSGCIRCFHPVCLKlnpaffivekKWNCPEC 335  yellow fever mosquito

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