Conserved Protein Domain Family
PHD_PHRF1
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cd15536: PHD_PHRF1 
PHD finger found in PHD and RING finger domain-containing protein 1 (PHRF1)
PHRF1, also termed KIAA1542, or CTD-binding SR-like protein rA9, is a ubiquitin ligase that induces the ubiquitination of TGIF (TG-interacting factor) at lysine 130. It acts as a tumor suppressor that promotes the transforming growth factor (TGF)-beta cytostatic program through selective release of TGIF-driven promyelocytic leukemia protein (PML) inactivation. PHRF1 contains a plant homeodomain (PHD) finger and a RING finger.
Links
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Statistics
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PSSM-Id: 277011
Aligned: 11 rows
Threshold Bit Score: 80.9215
Created: 12-Aug-2013
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Zn binding siteputative
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C [CH] H [CH] C [CH]Click to see conserved feature residue pattern help
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #  #           #  #    #  #              #  #
Q9P1Y6        185 FCEVCGRsDREDRLLLCDGCDAGYHMECLDPPLqeVPVDEWFCPEC 230  human
AAI42797      185 SCEICGGrDREDRLLLCDGCDAGYHMECPTPPLdaVPVEEWFCPEC 230  zebrafish
AAI60787      172 NCAVCGRcDREDRLLLCDGCDAGYHMECLTPPLnaVPVDEWFCPEC 217  African clawed frog
XP_002107931  115 YCEVCNEcNREDRLLLCDGCNKGYHCECLTPPLehIPIDDWFCPDC 160  Trichoplax adhaerens
XP_002408581  144 YCEVCGNcDREDRLLLCDACDLGYHCECLTPPLdtVPVEEWYCPDC 189  black-legged tick
XP_002608498  208 YCQVCHQpTNEDRMLLCDSCDAGYHMECLTPPLdaVPIEEWFCPHC 253  Florida lancelet
EKC34304      183 FCEACGRsDREDRLLLCDGCDLGYHCECLNPPLaeVPAEEWYCPDC 228  Pacific oyster
EMP34739      198 FCEVCGRsDREDRLLLCDGCDAGYHMECLNPPLseIPVDEWFCPAC 243  green seaturtle
NP_001242966  222 FCEVCHQsNREDRMLLCDGCDCGYHLECLTPPLneVPIEEWFCPEC 267  honey bee
XP_006814886  255 YCEVCGRcDREDRLLLCDGCDAGYHCECLDPPLrnIPVEEWFCPEC 300  Saccoglossus kowalevskii
O94400        124 RCVICGRsDHAEVLLLCDGCDDAYHTYCLNMDA--VPIEEFYCPNC 167  Schizosaccharomyces pombe 972h-

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