Conserved Protein Domain Family
PHD1_PHF12
?
cd15533: PHD1_PHF12 
PHD finger 1 found in PHD finger protein 12 (PHF12)
PHF12, also termed PHD factor 1 (Pf1), is a plant homeodomain (PHD) zinc finger-containing protein that bridges the transducin-like enhancer of split (TLE) corepressor to the mSin3A-histone deacetylase (HDAC)-complex, and further represses transcription at targeted genes. PHF12 also interacts with MRG15 (mortality factor-related genes on chromosome 15), a member of the mortality factor (MORF) family of proteins implicated in regulating cellular senescence. PHF12 contains two plant-homeodomain (PHD) zinc fingers followed by a polybasic region. The PHD fingers function downstream of phosphoinositide signaling triggered by the interaction between polybasic regions and phosphoinositides. This model corresponds to the first PHD finger.
Links
?
Statistics
?
PSSM-Id: 277008
Aligned: 21 rows
Threshold Bit Score: 81.634
Created: 13-Aug-2013
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
Download Cn3D
 
Zn binding siteputative
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C [CH] H [CH] C [CH]Click to see conserved feature residue pattern help
Evidence:
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1          #  #         #  #    #  #                #  #
Q96QT6         58 SCDSCKEG-GDLLCCDhCPAAFHLQCCNPPLseemLPPGEWMCHRC 102  human
XP_001636189   50 NCDSCGEG-GDLLCCDqCPCAFHLSCCDPPLeeddIPDGEWLCIEC 94   starlet sea anemone
XP_002402600   50 ACDSCNEG-GDLICCDrCPATFHLQCHDPPLdeddLPAGEWICHRC 94   black-legged tick
XP_002115152   46 TCDSCNEG-GDLLCCErCPSAFHLHCCDPPLdedgIPAGEWICKKC 90   Trichoplax adhaerens
XP_004342399   29 NCDSCGEG-GELICCDrCPASFHLECLNPPLp--cVPDGDWFCRAC 71   Acanthamoeba castellanii str. Neff
NP_572311      55 YCDACEEG-GNLLCCDrCPSSFHLQCHDPPLseedIPSGQWLCHSC 99   fruit fly
EJW77543       58 YCSSCMEG-GELLCCDrCPASFHLMCHEPPIerssIPSGKWLCNRC 102  agent of lymphatic filariasis
CCD76997       88 YCDSCGCIeGERLVCDrCPASFHLECLDPPLdpdeAPVGVWFCHRC 133  Schistosoma mansoni
XP_642746      63 YCSGCGDG-GDLLCCDnCQASFHLICLNPPLn--eIPSGDWFCDSC 105  Dictyostelium discoideum AX4
CBY37908       40 YCEACKDG-GELVCCEkCPISYHPTCTNPPCda-nDLPDKWICRGC 83   Oikopleura dioica

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap