Conserved Protein Domain Family
PHD3_Lid2p_like
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cd15520: PHD3_Lid2p_like 
PHD finger 3 found in Schizosaccharomyces pombe Lid2 complex component Lid2p and similar proteins
Lid2p is a trimethyl H3K4 (H3K4me3) demethylase responsible for H3K4 hypomethylation in heterochromatin. It interacts with the histone lysine-9 methyltransferase, Clr4, through the Dos1/Clr8-Rik1 complex, and mediates H3K9 methylation and small RNA production. It also acts cooperatively with the histone modification enzymes Set1 and Lsd1, and plays an essential role in cross-talk between H3K4 and H3K9 methylation in euchromatin. Lid2p contains a JmjC domain, three PHD fingers and a JmjN domain. The family corresponds to the third PHD finger.
Links
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Statistics
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PSSM-Id: 276995
Aligned: 3 rows
Threshold Bit Score: 58.7683
Created: 20-Mar-2014
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Zn binding siteputative
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C [CH] H [CH] C [CH]Click to see conserved feature residue pattern help
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1       #  #            #    #    #  #               #  #
Q9HDV4    1354 SCl-CGEefsprdSFIDCTI--CERRFHYDCVGLnneiadsvskFTCPIC 1400 Schizosaccharomyces pombe 972h-
EEB08480  1305 DCi-CNQpfeigdLLVSCVG--CERHYHCDCVGLsasivdsmrsFVCPSC 1351 Schizosaccharomyces japonicus yFS275
CBH17010   104 RCgvCGEgdn-aiRMIFCDRsqCDYTVHLDCVGMsdr----pseFFCSEC 148  Trypanosoma brucei gambiense DAL972

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