Conserved Protein Domain Family
PHD1_Lid2p_like
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cd15519: PHD1_Lid2p_like 
PHD finger 1 found in Schizosaccharomyces pombe Lid2 complex component Lid2p and similar proteins
Lid2p is a trimethyl H3K4 (H3K4me3) demethylase responsible for H3K4 hypomethylation in heterochromatin. It interacts with the histone lysine-9 methyltransferase, Clr4, through the Dos1/Clr8-Rik1 complex, and mediates H3K9 methylation and small RNA production. It also acts cooperatively with the histone modification enzymes Set1 and Lsd1 and plays an essential role in cross-talk between H3K4 and H3K9 methylation in euchromatin. Lid2p contains a JmjC domain, three PHD fingers and a JmjN domain. This model corresponds to the first PHD finger.
Links
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Statistics
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PSSM-Id: 276994
Aligned: 6 rows
Threshold Bit Score: 76.3503
Created: 20-Mar-2014
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Zn binding siteputative
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C [CH] H [CH] C [CH]Click to see conserved feature residue pattern help
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #  #              #  #    #  #                #  #
Q9HDV4        270 QCEYCGLdk---npETILLCDgCEAAYHTSCLDPPLtsi--pkeDWYCDAC 315  Schizosaccharomyces pombe 972h-
Q9SGH2       1289 VCKVCGVdk---ddDSVLLCDtCDAEYHTYCLNPPLiri--pdgNWYCPSC 1334 thale cress
XP_005652282  795 GCEECGKnd---rgEEMLLCDgCDHGYHTDCLDPPLkei--pegDWFCPSC 840  Coccomyxa subellipsoidea C-169
XP_003078710  904 GCIVCGLdv---maGVVLLCDsCDAEYHTKCLDPPLsae--pegEWFCPTC 949  Ostreococcus tauri
XP_007512770 1170 GCQSCGMdmheggkGEVLLCDgCPREFHKSCLNPPVdeneklpdTWFCPIC 1220 Bathycoccus prasinos
EKX49122       47 TCEACNRgd---neMQLILCDgCDHACHLACMDPPVgfv---peTWFCRRC 91   Guillardia theta CCMP2712

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