4P3G,4P3E


Conserved Protein Domain Family
SRP68-RBD

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cd15481: SRP68-RBD 
Click on image for an interactive view with Cn3D
RNA-binding domain of signal recognition particle subunit 68
Signal recognition particles (SRPs) are ribonucleoprotein complexes that target particular nascent pre-secretory proteins to the endoplasmic reticulum. SRP68 is one of the two largest proteins found in SRPs (the other being SRP72), and it forms a heterodimer with SRP72. Heterodimer formation is essential for SRP function. This model characterizes the N-terminal RNA-binding domain SRP68-RBD, a tetratricopeptide-like module. Interactions between SRP68-RBD and SRP RNA (7SL RNA) are thought to facilitate a conformation of SRP RNA that is required for interactions with ribosomal RNA.
Links
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Statistics
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PSSM-Id: 271252
Aligned: 68 rows
Threshold Bit Score: 135.43
Created: 11-Jun-2014
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
RNA binding
Conserved site includes 25 residues -Click on image for an interactive view with Cn3D
Feature 1:RNA binding site [nucleic acid binding site]
Evidence:
  • Structure:4P3E: human Srp68 binds SRP RNA, contacts at 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                    #         ## # # ###### ###                             #          # 
4P3G_A          9 DITKFVVTSREKALLy--GDYATYRTQLSGKLLNCRKKLniatknrgkfhp---ktaitpeqiaeNTEYVRLQLLTAERA 83   Chaetomium th...
4P3E_C         23 EILQIIKESQQQHGLr-hGDFQRYRGYCSRRQRRLRKTLnfkmgnrhkft-----gkkvtedlltDNRYLLLVLMDAERA 96   human
EDK38170        3 SPLGDTIGARLNAYLtsaEDFKKQRKRINRKLLRLRHELkivtkdtkkfkd--ktsqvtpeayekDARYGLLLLLTAERD 80   Meyerozyma gu...
XP_002490243    3 SPLQSTYGERAERYLdsaDAFHKQRHRLNRRLHKLRKSLdihvtdtknyrekeqiskidlesynrDKRYGDIILFTAERD 82   Komagataella ...
XP_002618293    5 SPLGSTFGARLSDSLtspEDFRKCRRRLNKSLCKLRHNLkivshktesyn----ppkvgaeqynaDQRYGDLLLLLAERY 80   Clavispora lu...
CCE42327        3 SALNTTLGARLSAYLvtaDDFKRQRTRVNKRILKLRRDLnlvtkdtknygakeqtskitpqqydeNKDYGLIELLLAERD 82   Candida parap...
CCH42897        4 SPLALTIGQRNSAFLstpQDFHKQRVKITRRIHNLKRYLkiqskntkdyk----preltiddyqtDNKYYLLSLLLVERD 79   Wickerhamomyc...
XP_004198581    3 SPLKWTLGARMSAYLtstDDYRRHRKNINKNLVRIRRKLglvtkdtknyed--kvalitsdkydeNKLYGSILLLTAERD 80   Pichia farino...
EMG49077        3 SPLGTTLGARMSAYLvtsNDFKKQRKRINKQLKNLRHELgliihntkkye----aikltpdqyneNNKYGLIYLLLAERD 78   Candida malto...
XP_006690183    3 SPLSITVGARMSAFLnsaEDFHKYRKRLNKTILRLRHELnlvtrdtknykdkeriskissedysnDERFGLILLLTAERD 82   Candida tenui...
Feature 1           #                    ## ##  ##  #  #                                          
4P3G_A         84 WAHAXAXKaahsan---tkgxtgRTRSHIVSRLEKGARIAEKLAQALsdgasgaSPTDILDARAYAALLRGAALFEkqnw 160  Chaetomium th...
4P3E_C         97 WSYAMQLKqean--------tepRKRFHLLSRLRKAVKHAEELERLCesn--rvDAKTKLEAQAYTAYLSGMLRFEhqew 166  human
EDK38170       81 LMYSSEIKstmeis----nenlsSYRQLMISKIKKALIHCKRLLAVIsn---esRKSVVLETFVYSALVQGLYSLNkkkw 153  Meyerozyma gu...
XP_002490243   83 HMYSDEVKeimkv------hhskSREKFIVSRLKRSLDHGRKLLILVgd---epDEMRKLEVFVYVALIQGKLSIAnknw 153  Komagataella ...
XP_002618293   81 SLHALEAKsfleig----vdgtkYYKQLMRNKLQRAATTTEQLIEMTkd---eqSTIKKVEIFVYAALTEGANAIFrkqw 153  Clavispora lu...
CCE42327       83 MLYASEIKakldin----sekssSYTTLLKTKMKRALFHVDNLIKLTag---evNDKIRIEVYIYAALVAGQLSITrkqw 155  Candida parap...
CCH42897       80 YLYALELKafldlnsnnnvnsikSKTKLILTRLKKSKQNGNLLVKISkd---esDLTKRLEILVYNELISGFYSILnknw 156  Wickerhamomyc...
XP_004198581   81 MLYALEIKnmleis----nenvsSYKNLMLSRMKKSLSTSKLLLQVIqn---enDFIIKIESYVYAAIVQGFFSINkrkw 153  Pichia farino...
EMG49077       79 ILYGLDIKnlmeid----ekskkNYKNLMITKLKRSAFHATNLLELTkd---esNKRTRIELFVYTALIVGQLSIAkkqw 151  Candida malto...
XP_006690183   83 LVYSLEIKsmmeis----segssSYKNLMVSRLKKSVSSTKQLLQVVen---etNELKIIEVYVYAALNEGSLAVNkrkw 155  Candida tenui...
Feature 1                                                                    
4P3G_A        161 GACLKSYAICRIIYTALATss----------------kGDIFKELLSDtIDPSXRFAAY 203  Chaetomium thermophilum var. therm...
4P3E_C        167 KAAIEAFNKCKTIYEKLASaft-------------eeqAVLYNQRVEE-ISPNIRYCAY 211  human
EDK38170      154 EASIHAYSVARCGLDYFLLhgdq-----------tnleRAAIEEIMDSiVDPSLTFAIS 201  Meyerozyma guilliermondii ATCC 6260
XP_002490243  154 TNAQYALSVARCGLQFLDKygt-------------etqTDLYNGIIDThIDQMLKFVIY 199  Komagataella pastoris GS115
XP_002618293  154 DKALSAYSSARCGLELLLDiltgd---------essfnKTLLEELIDTsVDPSLRLALS 203  Clavispora lusitaniae ATCC 42720
CCE42327      156 FKALNAISIAKCSLDYLNAqdsnk----------esfnKTLCNELLENtVDPSLNLAAS 204  Candida parapsilosis
CCH42897      157 SQAIQNYSNSRIGLKFLELnge-------------qenKILYKDIIEElIDDSLKLAIY 202  Wickerhamomyces ciferrii
XP_004198581  154 DLALDAFSFAKCALEFLSAklkssessetsqgetsdlrETLFKELLDElVDPSLNLALS 212  Pichia farinosa CBS 7064
EMG49077      152 SKVLNSFSIAKCCLDSLYNeehddd--------ddsfdKTLFNELTETlVDPSLNLAIN 202  Candida maltosa Xu316
XP_006690183  156 QSALNAFSIARCALEYLYSqqtdqe--------qeqfnKTVINDLIETlVDPSLALSVS 206  Candida tenuis ATCC 10573

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