4LL6,4LL8,3MMI


Conserved Protein Domain Family
fMyo4p_CBD
?
cd15479: fMyo4p_CBD 
Click on image for an interactive view with Cn3D
cargo binding domain of fungal myosin 4
Yeast myosin V travels along actin cables, actin filaments that are bundled by fimbrin, in the presence of tropomyosin. This is in contrast to the other vertebrate class V myosins. Like other class V myosins, fungal myosin 2 and 4 contain a C-terminal cargo binding domain. In case of Myo4 it has been shown to bind to the adapter protein She3p (Swi5p-dependent HO expression 3), which in turn anchors myosin 4 to its cargos, zip-coded mRNP (messenger ribonucleoprotein particles) and tER (tubular endoplasmic reticulum).
Links
?
Statistics
?
PSSM-Id: 271263
Aligned: 4 rows
Threshold Bit Score: 632.01
Created: 17-Apr-2014
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
She3P
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:She3P interaction interface [polypeptide binding site]
Evidence:
  • Structure:4LL8: Yeast Myo4 CBD bound to middle fragment of the adaptor protein She3 ( Swi5-dependent HO expression protein 3), contacts at 4 A
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                     
4LL6_A     16 CYTLEVTEGYLKKVNvtevngDNVLGPIHVITTVVSSLVrnglliQSSKFISKVLLTVESIVMslpkdETMLGGIFWLSN 95  Saccharomyces cere...
4LL8_A    181 SYTLEVTEGYLKKVNvtevngDNVLGPIHVITTVVSSLVrnglliQSSKFISKVLLTVESIVMslpkdETMLGGIFWLSN 260 Saccharomyces cere...
3MMI_A     28 CYTLEVTEGYLKKVNvtevngDNVLGPIHVITTVVSSLVrnglliQSSKFISKVLLTVESIVMslpkdETMLGGIFWLSN 107 baker's yeast
AAO32405  115 GYTLEITESFLKKINvaeldeNRALGPVQAISTVVNSLVrhglliQTSKFMSKVLLTFENIVMnlpkdQTMVGGIFWLSN 194 Saccharomyces bayanus

Feature 1                                                                                     
4LL6_A     96 LSRLPAFAANQKtlyeanggdekdkltliYLNDLENETLKVFDKIYSTWLVKFMKHASAhieifdmvlneklfknsgdeK 175 Saccharomyces cere...
4LL8_A    261 LSRLPAFAANQKtlyeanggdekdkltliYLNDLENETLKVFDKIYSTWLVKFMKHASAhieifdmvlneklfknsgdeK 340 Saccharomyces cere...
3MMI_A    108 LSRLPAFAANQKtlyeanggdekdkltliYLNDLENETLKVFDKIYSTWLVKFMKHASAhieifdmvlneklfknsgdeK 187 baker's yeast
AAO32405  195 LSRFPPFVANQKtlydgngkdekdrlallYLNELENESVRVFDKIYSIWLVKLMKHVSVnmniselmldektftnprdeK 274 Saccharomyces bayanus

Feature 1                                                         #                           
4LL6_A    176 FAKLFTFLNEFDAVLCKfqvvdSMHTKIFNDTLKYLNVMLFNDLITKCpaLNWKYGYEVDRNIERLVSWFEPRIEDVRPN 255 Saccharomyces cere...
4LL8_A    341 FAKLFTFLNEFDAVLSKfqvvdSMHTKIFNDTLKYLNVMLFNDLITKSpaLNWKYGYEVDRNIERLVSWFEPRIEDVRPN 420 Saccharomyces cere...
3MMI_A    188 FAKLFTFLNEFDAVLCKfqvvdSMHTKIFNDTLKYLNVMLFNDLITKCpaLNWKYGYEVDRNIERLVSWFEPRIEDVRPN 267 baker's yeast
AAO32405  275 FAEIRVFLDKFDSAMHQfkvggTVRTKIYNDILKYLNVLLFNDLITKCptLNWKYGHEVDKNIKQLMAWFEPKTDGARSN 354 Saccharomyces bayanus

Feature 1      #      #  ###     #  ## ## #                                                   
4LL6_A    256 LIQIIQAVKILQLNIsnlnEFKLLFDFWYALNPAQIQAILLKYKPANkGEAGVPNEILNYLANVIKREnlslpgkmeimL 335 Saccharomyces cere...
4LL8_A    421 LIQIIQAVKILQLKIsnlnEFKLLFDFWYALNPAQIQAILLKYKPANkGEAGVPNEILNYLANVIKREnlslpgkmeimL 500 Saccharomyces cere...
3MMI_A    268 LIQIIQAVKILQLKIsnlnEFKLLFDFWYALNPAQIQAILLKYKPANkGEAGVPNEILNYLANVIKREnlslpgkmeimL 347 baker's yeast
AAO32405  355 LIQTVQSVKILQMKIgnlkEFKLLFDFWYALNPAQIQAILLKYKPTSkNEVGVPNEILNYLANLVKREnsalpgkmeimL 434 Saccharomyces bayanus

Feature 1              
4LL6_A    336 SAQFDSAKN 344 Saccharomyces cerevisiae S288c
4LL8_A    501 SAQFDSAKN 509 Saccharomyces cerevisiae S288c
3MMI_A    348 SAQFDSAKN 356 baker's yeast
AAO32405  435 TADFDSIKK 443 Saccharomyces bayanus

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap