4J5L,3WB8,4LLI,4KP3,4LX1


Conserved Protein Domain Family
Myo5a_CBD
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cd15478: Myo5a_CBD 
Click on image for an interactive view with Cn3D
Cargo binding domain of myosin 5a
Class V myosins are well studied unconventional myosins, represented by three paralogs (Myo5a,b,c) in vertebrates. Their C-terminal cargo binding domains (CBDs) are important for the binding of a diverse set of cargos, including membrane vesicles, organelles, proteins and mRNA. They interact with several adaptor proteins, in case of Myo5a-CBD, melanophilin (MLPH), Rab interacting lysosomal protein-like 2 (RILPL2), and granuphilin. Mutations in human Myo5a (many of which map to the cargo binding domain) lead to Griscelli syndrome, a severe neurological disease.
Links
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Statistics
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PSSM-Id: 271262
Aligned: 8 rows
Threshold Bit Score: 708.334
Created: 17-Apr-2014
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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melanophilinRILPL2
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:melanophilin interface [polypeptide binding site]
Evidence:
  • Structure:4KP3; Homo sapiens Myo5a CBD in complex with melanophilin, contacts 4A
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                      #  ##  ##  ##  #                   
4J5L_A         34 KEDEQKLVKNLILELKPRGVAVNLIPGLPAYILFMCVRHADYLNDDQKVRSLLTSTINSIKKVLKKRGDDFETVSFWLSN 113  human
3WB8_A         30 REDEQKLVKNLILELKPRGVAVNLIPGLPAYILFMCVRHADYLNDDQKVRSLLTSTINSIKKVLKKRGDDFETVSFWLSN 109  house mouse
4LLI_A         21 KEDEQKLVKNLILELKPRGVAVNLIPGLPAYILFMCVRHADYLNDDQKVRSLLTSTINSIKKVLKKRGDDFETVSFWLSN 100  human
4KP3_A         30 REDEQKLVKNLILELKPRGVAVNLIPGLPAYILFMCVRHADYLNDDQKVRSLLTSTINSIKKVLKKRGDDFETVSFWLSN 109  house mouse
4LX1_A         18 KEDEQKLVKNLILELKPRGVAVNLIPGLPAYILFMCVRHADYLNDDQKVRSLLTSTINSIKKVLKKRGDDFETVSFWLSN 97   human
Q02440       1455 KEDEQKLVKNLILELKPRGVAVNLIPGLPAYILFMCVRHADYLNDDQKVRSLLTSTINGIKKVLKKRGDDFETVSFWLSN 1534 chicken
XP_004912754 1451 KEDELKLVKNLILELKPRGVAVNLIPGLPAYILFMCLRHADYLNDDQKVRSLLTSTINGIKKILKKRGDDFETVSFWLSN 1530 western clawe...
XP_005173733 1453 KEDELKLVKNIILELKPRGVAVNLIPGLPAYILFMCLRHADYINDDQKVRSLLTSVINSIKKILKKRGDDFETVSFWLAN 1532 zebrafish

Feature 1                    #                 ###### ##  #                                       
4J5L_A        114 TCRFLHCLKQYSGEEGFMKHntsrqneHCLTNFDLAEYRQVLSDLAIQIYQQLVRVLENILQPMIVSGMLEHETIQGVSG 193  human
3WB8_A        110 TCRFLHCLKQYSGEEGFMKHntsrqneHCLTNFDLAEYRQVLSDLAIQIYQQLVRVLENILQPMIVSGMLEHETIQGVSG 189  house mouse
4LLI_A        101 TCRFLHCLKQYSGEEGFMKHntsrqneHCLTNFDLAEYRQVLSDLAIQIYQQLVRVLENILQPMIVSGMLEHETIQGVSG 180  human
4KP3_A        110 TCRFLHCLKQYSGEEGFMKHntsrqneHCLTNFDLAEYRQVLSDLAIQIYQQLVRVLENILQPMIVSGMLEHETIQGVSG 189  house mouse
4LX1_A         98 TCRFLHCLKQYSGEEGFMKHntsrqneHCLTNFDLAEYRQVLSDLAIQIYQQLVRVLENILQPMIVSGMLEHETIQGVSG 177  human
Q02440       1535 TCRFLHCLKQYSGEEGFMKHntprqneHCLTNFDLAEYRQVLSDLAIQIYQQLVRVLENILQPMIVSGMLEHETIQGVSG 1614 chicken
XP_004912754 1531 SCRFLHCLKQYSGEEGFMKHnttrqneHCLTNFDLAEYRQVLSDLAIQIYQQLVRVLENILQPMIVSGMLEHETIQGVSG 1610 western clawe...
XP_005173733 1533 TCRFLHCLKQYSGDEQFMKHnspkqneHCLSNFDLAEYRQVLSDLAIQIYQQLIKCMENILQPMIVSGMLEHETIQGVSG 1612 zebrafish

Feature 1                                                                                         
4J5L_A        194 VKPTGLRKRTSSIaDEGTYTLDSILRQLNSFHSVMCQHGMDPELIKQVVKQMFYIIGAITLNNLLLRKDMCSWSKGMQIR 273  human
3WB8_A        190 VKPTGLRKRTSSIaDEGTYTLDSILRQLNSFHSVMCQHGMDPELIKQVVKQMFYIVGAITLNNLLLRKDMCSWSKGMQIR 269  house mouse
4LLI_A        181 VKPTGLRKRTSSIaDEGTYTLDSILRQLNSFHSVMCQHGMDPELIKQVVKQMFYIIGAITLNNLLLRKDMCSWSKGMQIR 260  human
4KP3_A        190 VKPTGLRKRTSSIaDEGTYTLDSILRQLNSFHSVMSQHGMDPELIKQVVKQMFYIVGAITLNNLLLRKDMCSWSKGMQIR 269  house mouse
4LX1_A        178 VKPTGLRKRTSSIaDEGTYTLDSILRQLNSFHSVMCQHGMDPELIKQVVKQMFYIIGAITLNNLLLRKDMCSWSKGMQIR 257  human
Q02440       1615 VKPTGLRKRTSSIaDEGTYTLDSIIRQLNSFHSVMCQHGMDPELIKQVVKQMFYIIGAVTLNNLLLRKDMCSWSKGMQIR 1694 chicken
XP_004912754 1611 VKPTGLRKRTSSIaDEGTYTLDSIVRQLNTFHSIMCQHGMDPELIKQVVKQMFYIIGAVTLNNLLLRKDMCSWSKGMQIR 1690 western clawe...
XP_005173733 1613 VKPTGLRKRTSSIaDEGTYTLDSIIRQLNTFHSIMCHHGTDPELIKQVVKQQFYIIGAVTLNNLLLRKDMCSWSKGMQIR 1692 zebrafish

Feature 1                                                                                         
4J5L_A        274 YNVSQLEEWLRDKNLMNSGAKETLEPLIQAAQLLQVKKKTDDDAEAICSMCNALTTAQIVKVLNLYTPVNEFEERVSVSF 353  human
3WB8_A        270 YNVSQLEEWLRDKNLMNSGAKETLEPLIQAAQLLQVKKKTDDDAEAICSMCNALTTAQIVKVLNLYTPVNEFEERVSVSF 349  house mouse
4LLI_A        261 YNVSQLEEWLRDKNLMNSGAKETLEPLIQAAQLLQVKKKTDDDAEAICSMCNALTTAQIVKVLNLYTPVNEFEERVSVSF 340  human
4KP3_A        270 YNVSQLEEWLRDKNLMNSGAKETLEPLIQAAQLLQVKKKTDDDAEAICSMCNALTTAQIVKVLNLYTPVNEFEERVSVSF 349  house mouse
4LX1_A        258 YNVSQLEEWLRDKNLMNSGAKETLEPLIQAAQLLQVKKKTDDDAEAICSMCNALTTAQIVKVLNLYTPVNEFEERVSVSF 337  human
Q02440       1695 YNVSQLEEWLRDKNLMNSGAKETLEPLIQAAQLLQVKKKTDEDAEAICSMCNALTTAQIVKVLNLYTPVNEFEERVLVSF 1774 chicken
XP_004912754 1691 YNVSQLEEWLRDKNLMNSSAKETLEPLIQAAQLLQVKKKTDEDAEAICSMCNALTTAQIVKVLNLYTPVNEFEERVLVSF 1770 western clawe...
XP_005173733 1693 YNVSQLEEWLRDKNLMTCGAKETLEPLIQAAQLLQVKKKTDEDAEAICSMCNALSTAQIVKVLNLYTPVNAFEERVSVLF 1772 zebrafish

Feature 1                                                                
4J5L_A        354 IRTIQMRLRDRKDSPQLLMDaKHIFPVTFPFNPSSLALETIQIPASLGLGFISRV 408  human
3WB8_A        350 IRTIQMRLRDRKDSPQLLMDaKHIFPVTFPFNPSSLALETIQIPASLGLGFIARV 404  house mouse
4LLI_A        341 IRTIQMRLRDRKDSPQLLMDaKHIFPVTFPFNPSSLALETIQIPASLGLGFISRV 395  human
4KP3_A        350 IRTIQMRLRDRKDSPQLLMDaKHIFPVTFPFNPSSLALETIQIPASLGLGFIARV 404  house mouse
4LX1_A        338 IRTIQMRLRDRKDSPQLLMDaKHIFPVTFPFNPSSLALETIQIPASLGLGFISRV 392  human
Q02440       1775 IRTIQLRLRDRKDSPQLLMDaKHIFPVTFPFNPSSLALETIQIPASLGLGFISRV 1829 chicken
XP_004912754 1771 IRNIQMRLRDRKDSPQLLMDaKHIFPVTFPFNPSSLALETIQIPGSLGLAFLTRV 1825 western clawed frog
XP_005173733 1773 IRTIQTRLRDRKESPQLLMDtKLIYPVTFPFNPSSLALETIQIPSSLNLAFLTRV 1827 zebrafish

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