4L8T


Conserved Protein Domain Family
Myo5c_CBD
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cd15476: Myo5c_CBD 
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Cargo binding domain of myosin 5C
Class V myosins are well studied unconventional myosins, represented by three paralogs (Myo5a,b,c) in vertebrates. Their C-terminal cargo binding domains (CBDs) are important for the binding of a diverse set of cargos, including membrane vesicles, organelles, proteins and mRNA. The MyoV-CBDs directly interact with several adaptor proteins.MyoVb and myoVc areprimarily expressed in epithelial cells, and have been implicated as motors involved in recycling endosomes.
Links
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Statistics
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PSSM-Id: 271260
Aligned: 11 rows
Threshold Bit Score: 614.098
Created: 17-Apr-2014
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4L8T_A         74 EDEAKLIQNLILDLKprgv-----vvnMIPGLPAHILFMCVRYADslndANMLKSLMNSTINGIKQVVKehlEDFEMLSF 148  human
XP_006789228 1368 EDEPRLIENIILDLKlkgv-----avnMIPTLPAYILFMCIRHVDylndEAKLKSLMNAIIVGVKKVIMshqKDLEFLSF 1442 Neolamprologu...
XP_003641891 1364 EDEERIVQNLILDLKprgv-----vvnMIPGLPAHILFMCVRYADylndADMLKSFINVTIDGIKQVVKensEDFEMLSF 1438 chicken
XP_691143    1366 EDEGRLIRILILELKprgv-----gvnMIPGLAAHLLFMCVRHADylndGNKLKCLMNNIITAVKEVITehqENFELLSF 1440 zebrafish
XP_004070003 1373 EDESRLVQNVILDLQpkgv-----vvnMIPCLPAYILFMCVRHADylndDAKLKSLMSAIICAVKKVILsrcKDFVLLSF 1447 Japanese medaka
XP_006628720 1369 EDEGKIINNLILELKprgv-----vvnMIPGLPAHLLFMCIRHADylsdATKLKSLMNAIISGIKVVIKdhqEDFEMLSF 1443 spotted gar
XP_002936392 1346 EDESKLIRNLILDLKprgv-----vvnMIPGLPAHIMFMCVRYTDyinnAERIKSLMNASINSIKQVIKehaDDFEMLSF 1420 western clawe...
XP_006009176 1371 EDEAKLIKHLVLDLKprgv-----vvnMFPGLPAHIMFMCVRYADhlndADRLKSLMNSIINGIKEASQnhaGDFEMLSF 1445 coelacanth
XP_005809964 1316 EDEARLIQNIITDLKpkgv-----vvnVIPTLPAFILFMCVRHADylndDNKLKSLMNGIIQGVKKVVVahhKDFESLSF 1390 southern plat...
XP_007235204 1365 EDEDKLVRMLIRELKprgv-----vvnMIPGLAANLLFMCVRHSDylndGNKLKSLMHAIITAVKQVITdhqENFEILSF 1439 Mexican tetra
ERE76286     1371 EDEAKIIQNLILGSGwktqllvlawwsTPVSPALGGKKAEILHMPyp-rGQKRVSPPGAGVTGSCWLPNehfEDLEMLSF 1449 Chinese hamster

4L8T_A        149 WLSNTCHFLNCLKQYSgeeefmkhnspqqnkncLNNFDLSEYRQILSDVAIRIYHQFIIIMEKNIQPiivpgmleyeslq 228  human
XP_006789228 1443 WLSNTHQLLNCLKQYSgeeeflkqstprqkkncLKNFDLSEHRQILSDLAIQIYHRFISVMQKTLTPtivpgmleheslq 1522 Neolamprologu...
XP_003641891 1439 WLSNTYYFLNCLKQYSgeeefmkyntphqnkncLKHFDLSEYRQVLSDLAIRIYHQFILVMENNIQHmvvpgmleyeslq 1518 chicken
XP_691143    1441 WLSNTYHFLNCLKQYSgeeefmkhntprqnkncLKNFDLSEHRQILSDLAINIYHQFISVMEDALFPmiipgmleheslq 1520 zebrafish
XP_004070003 1448 WLSNTHQLINLLKQYSgeeeflkqssprqrkncLQNFDLSEHRQIFSDLAIHIYHQFISVLQKILTPaivpgmleheslq 1527 Japanese medaka
XP_006628720 1444 WLSNSCHMLNCLKQYSgeeelmkhntprqnkncLRNFDLSEHRQIFSDLAIRIYHQFISVMENCLMPmivpgmleheslq 1523 spotted gar
XP_002936392 1421 WLSNVHHFLNCLKQYSgeeefmkynqplqnkncLKNFDLSEYRQIISDLAIRIYHQFITVMENNLQPmivpgmleyeslh 1500 western clawe...
XP_006009176 1446 WLSNIYHFLNCLRQYSgeeefmkhntsrqnnncLKNFDLSEHRQILSDLAIRIYQQFITVMENNIQSmivpgmleheslq 1525 coelacanth
XP_005809964 1391 WLSNTYRLLNCLKQYSgeeqflkqstprqkkncLQNFDLSEHRQILSDLAIQIYHQLISIMQKKLTPaivpgmleheslq 1470 southern plat...
XP_007235204 1440 WLSNTYYLLNCFKQYSgeeefmkhntprqnkncLQNFDLSEHRQILSDLAIRIYHQFINIMEDALFPmivpamleheslq 1519 Mexican tetra
ERE76286     1450 WLSNTCHFLNCLKQYSgeeefmkynspqqnkncLNNFDLTEYRQILSDVAIRIYHQFVVVMENSIQPiivpgmleyeslq 1529 Chinese hamster

4L8T_A        229 gisgl-------kptgfrkrsssiddtdgyTMTSVLQQLSYFYTTMCQnglDPELVRQAVKQLFFLIGAVTLNSLFLRKd 301  human
XP_006789228 1523 gissmk------ptgfrkrsnsfyeesetyTISSILQHLTVFHSTMNHhglDQGLIKQVIKQLFYLVAAITLNNIMLRKd 1596 Neolamprologu...
XP_003641891 1519 gisgl-------kptgfrkrsssiddtdtyTMTSILQQLSYFYSTMCQnglDPELLKQAVKQLFFLIGAVTLNSLFLRKd 1591 chicken
XP_691143    1521 gissmkptglrkrsssvfedggdsstseafSVSSILQKLSTFNSSMCQqgmEPQLQGQIVRQLFYLIGSSSVNCILLRKd 1600 zebrafish
XP_004070003 1528 gissmk-----ptgfrkrssslydeesknfTISSIIKQLSVFHSTMIHhgmDQNLINQVTKQLFFLVAATTLNQIMLRKd 1602 Japanese medaka
XP_006628720 1524 gissmk------ptglrkrstsiyedmevyTISSILQQLSYFHSTMCQhgmDAELMKQAVKQLFFLIGAVTLNSIFLRKd 1597 spotted gar
XP_002936392 1501 gisvs-------kptgfrkrsssiddtdsyTMTSILQQLSYFYTTMCQhgmDPELLKQTMKQLFFLIATVTINSLFLRKd 1573 western clawe...
XP_006009176 1526 gissmk------ptglrkrsssikedpdsyTITTLLQQLSYYYNTMCQhgmDPELIKQAVRQLFFLIGAVTLNNLFLRKd 1599 coelacanth
XP_005809964 1471 gissmk------ptgfrkrssslyndsetyTISSILQELSVFYSAMSHhgmEQSLTTQAVKQLFFLIGATTFNQIMLRKd 1544 southern plat...
XP_007235204 1520 gissmkpt--gfrkrsnslleegrsegqaySVSSILQLMNSFHNAMAQqgmELQLQGQAIRQLFYLIGATSLNSILLRKd 1597 Mexican tetra
ERE76286     1530 gisgl-------kptgfrkrsssiddtdayTMTSVLQQLSYFYSTMCQnglDPELVRQAVKQLFYLIGAVTLNSLLLRKd 1602 Chinese hamster

4L8T_A        302 mCSCRKGMQIRCNISYLEEWLKDKNLqnslaketLEPLSQAAWLLQVKKttdsDAKEIYERCTSLSAVQIIKILNSYTPI 381  human
XP_006789228 1597 mCSCRKGMQIRCNISYLEEWLKEKELqnvnamdtLKPLAQTAWLLQVNKstddDAKEIIEKCSELSPVQIVKILNSYTPI 1676 Neolamprologu...
XP_003641891 1592 mCSCRKGMQIRCNISYLEEWLKDKNLqssnaketLEPLSQAAWLLQVKKitddDAKEICEHCTSLSTVQIVKILNSYTPI 1671 chicken
XP_691143    1601 lCSCRKGMQIRCNISYLEEWLREKDLlssnametLGPLSQIAWLLQVNKttdeDAAEIKQRCSELSAVQIVKILNSYTPI 1680 zebrafish
XP_004070003 1603 mCSCRKGMQIRCNISYLEEWLKEKDLqssnametLTPLAQAAWLLQVNKstddDAKEITEKCTELNPVQIVKILNSYTPI 1682 Japanese medaka
XP_006628720 1598 mCSCRKGMQIRCNISYLEEWLKEKSLqncnaidtMEPLSQTAWLLQVNKstddDAKEICERCSGLSAVQIVKILNSYTPI 1677 spotted gar
XP_002936392 1574 mCSCRKGMQIRCNISYLEEWLQGKNLqgataketLEPLSQAAWLLQVKKitddDAKEIYERCTALSSVQIVKILNSYTPI 1653 western clawe...
XP_006009176 1600 mCSCRKGMQIRCNISYLEEWLKEKNLqnssaketMEPLSQVAWLLQVNKttddDAKEICDRCSSLSAVQIVKILNSYTPI 1679 coelacanth
XP_005809964 1545 mCSCRKGMQIRCNISYLEEWLKENELqscgaidtLRPLAQAAWLLQVNKstdeDAKEIAEKCTELNPVQIVKILNSYTPI 1624 southern plat...
XP_007235204 1598 lCSCRKGMQIRCNISYLEEWLREKGLqgcsametLGPLSQAAWLLQVNKttdeDAAEIRQQCRELSAVQIVKILNSYTPI 1677 Mexican tetra
ERE76286     1603 mCSCRKGMQIRCNISYLEEWLKDKNLqnssaketLEPLSQAAWLLQVKKttdsDAKEISECCTSLSAVQIIKILNSYTPI 1682 Chinese hamster

4L8T_A        382 DdFEKRVTPSFVRKVQALLNSRedssqlmldtkYLFQVTFPFTPSPHALeMIQIPSSFKL 441  human
XP_006789228 1677 DdFEKRVTSSFVRKVQSLLQDHegsaqlmldadYRFQVTFPFCTSTQALeLLQVPNSLHL 1736 Neolamprologus brichardi
XP_003641891 1672 DdFEKRVTPSFVRKVQAMLNNRedgpqlmldtkYRFQVTFPFTPSPHALeMIQVPSSFKL 1731 chicken
XP_691143    1681 DdFEKRVAPSFVRKVQALLQERegssqlmmdsqYRFQVTFPFCSSTQALeLLQIPSSLHL 1740 zebrafish
XP_004070003 1683 DdFEKRVTSSFVRKVQSLLIHEgstql-mldtdFHFQVTFPFQSSSQALeLLQVPASLHL 1741 Japanese medaka
XP_006628720 1678 DdFEKRVAPSFVRKVQSLLQGRegtsqlmldtkYRFQVTFPFSPSPQALeMIQIPSSLKL 1737 spotted gar
XP_002936392 1654 DdFEKRVTPSFVRKVQSMLNNRedcsqlmldskYLFQVTFPFSPSPHALeMIQIPSSLKL 1713 western clawed frog
XP_006009176 1680 DdFEKRVAPSFVRKVQSMLHNRedmpqlvldtkYQFQVTFPFTPSSQALeTIQVPSSLKL 1739 coelacanth
XP_005809964 1625 DdFEKRVTSSFVRQVQSFLQEYegatqlmldtdYRFQVTFPFCPSSTALeSLQVPSSLHL 1684 southern platyfish
XP_007235204 1678 DdFEKRVAPSFVRKVQGLLQERegsnqlmmdaqYRFQVTFPFCPSTQALeLLQVPSSLHL 1737 Mexican tetra
ERE76286     1683 DdFEKRVAPSFVRKVQALLNNRgdssqlmldtkYLFQVTFPFTASPHALeMTQIPSSFKL 1742 Chinese hamster
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