2RKC,4GJT,3INB,3ALZ,2ZB5,3ALW


Conserved Protein Domain Family
MV-h

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cd15467: MV-h 
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Measles virus hemagglutinin
The hemagglutinin (H) of measles virus plays several roles during viral infection; it participates in virus attachment to host cells via binding to a proteinaceous receptor and it has a stimulating effect on membrane fusion during the entry of the virus into the host cell by interacting with the fusion protein F. This model characterizes the globular ectodomain of measles hemagglutinin, minus the stalk region. Receptors for measles virus have been identified as the signaling lymphocyte activation molecule (SLAM, in particular its distal ectodomain), CD46, and nectin-4 in epithelial cells.
Statistics
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PSSM-Id: 271231
Aligned: 10 rows
Threshold Bit Score: 713.472
Created: 8-May-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 16 residues -Click on image for an interactive view with Cn3D
Feature 1:receptor binding site [polypeptide binding site]
Evidence:
  • Structure:3ALZ: Measles virus hemagglutinin binds a distal IG-like domain of its cellular recptor SLAM, contacts at 4A
  • Structure:3INB: Measles virus hemagglutinin binds the two N-terminal IG-like domains of CD46, contacts at 4A
  • Structure:4GJT: Measles virus hemagglutinin binds an IG-like domain of its epithelial receptor nectin-4, contacts at 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         ######                                                                      
2RKC_A     32 NCSGPTTIRGQFSNMSLSLLDLYLGRGYNVSSIVTMTSQGMYGGTYLVEKPILSSKrselsqlSMYRVFEVGVIRNPGLG 111 Measles virus
4GJT_A     43 NCSGPTTIRGQFSNMSLSLLDLYLSRGYNVSSIVTMTSQGMYGGTYLVGKPNLSSKgselsqlSMHRVFEVGVIRNPGLG 122 Measles virus stra...
3INB_A     36 NCSGPTTIRGQFSNMSLSLLDLYLGRGYNVSSIVTMTSQGMYGGTYLVEKPNLSSKrselsqlSMYRVFEVGVIRNPGLG 115 Measles virus stra...
3ALZ_A     42 NCSGPTTIRGQFSNMSLSLLDLYLGRGYNVSSIVTMTSQGMYGGTYLVEKPNLSSKrselsqlSMYRVFEVGVIRNPGLG 121 Measles virus stra...
2ZB5_A     42 NCSGPTTIRGQFSNMSLSLLDLYLGRGYNVSSIVTMTSQGMYGGTYLVEKPNLSSKrselsqlSMYRVFEVGVIRNPGLG 121 Measles virus stra...
3ALW_A      7 NCSGPTTIRGQFSNMSLSLLDLYLGRGYNVSSIVTMTSQGMYGGTYLVEKPNLSSKrselsqlSMYRVFEVGVIRNPGLG 86 
Q998P6    187 RCSGATTSVGRVFPLSVSLSMSLISKTSEIINMLTAISDGVYGKTYLLVPDYIEREfd----tQQIRVFEIGFIKPWLND 262 Canine distemper v...
Q56TT1    187 NCSGSIITRGKTTKPGLTLVNVYATRNFEVSFMITVISGGMYGKTYFLKPPDPDDPfe----fQTLRVFEVGVARDIGSQ 262 Porpoise morbilliv...
Q8B6X9    187 GCQGRTVTRAHFSELTLTLMDLDLEMKHNVSSVFTVVEEGLFGRTYTVWRSDARDPstdpgigHFLRVFEIGLVRDLGLG 266 Peste-des-petits-r...
P12567    187 NCTGPTTTKGQFSNISLTLSGIYSGRGYNISSMITITGKGMYGSTYLVGKYNQRARrpsivwqQDYRVFEVGIIRELGVG 266 Rinderpest virus (...
Feature 1                                                                                     
2RKC_A    112 APVFHMTNYLEQPVSNDLSNCMVALGELKLAALCHGEDSITIPYQGSGKGVSFQLVKLGvwksPTDMQSWVPLStdd--- 188 Measles virus
4GJT_A    123 APVFHMTNYFEQPVSNDFSNCMVALGELKFAALCHREDSITIPYQGSGKGVSFQLVKLGvwksPTDMRSWVPLStdd--- 199 Measles virus stra...
3INB_A    116 APVFHMTNYLEQPVSNDLSNCMVALGELKLAALCHGEDSITIPYQGSGKGVSFQLVKLGvwksPADMQSWVPLStdd--- 192 Measles virus stra...
3ALZ_A    122 APVFHMTNYLEQPVSNDLSNCMVALGELKLAALCHGEDSITIPYQGSGKGVSFQLVKLGvwksPTDMQSWVPLStdd--- 198 Measles virus stra...
2ZB5_A    122 APVFHMTNYLEQPVSNDLSNCMVALGELKLAALCHGEDSITIPYQGSGKGVSFQLVKLGvwksPTDMQSWVPLStdd--- 198 Measles virus stra...
3ALW_A     87 APVFHMTNYLEQPVSNDLSNCMVALGELKLAALCHGEDSITIPYQGSGKGVSFQLVKLGvwksPTDMQSWVPLStdd--- 163
Q998P6    263 MPLLQTTNYMVLPENSKAKVCTIAVGELTLGSLCVDESTVLLYHDSNGSQDSILVVTLGif-gATPMNQVEEVIpva--h 339 Canine distemper v...
Q56TT1    263 EPIMQMTNFMVIDEDEGLNFCLLSVGELKLAAVCVRKSPVTTKDIGGYKDEPFKVVTLGii-gDGLSNQKTEIYpti--d 339 Porpoise morbilliv...
Q8B6X9    267 PPVFHMTNYLTVNMSDDYRRCLLAVGELKLTALCTSSETVTLSERGVPKRKPLVVVILNl---AGPTLGGELYSvlptsd 343 Peste-des-petits-r...
P12567    267 TPVFHMTNYLELPRQPELETCMLALGESKLAALCLADSPVALHYGRVGDDNKIRFVKLGv--wASPADRDTLATlsai-d 343 Rinderpest virus (...
Feature 1                                                                                     
2RKC_A    189 pvIDRLYLSSHRGVIADNQAKWAVPTTRTDDKLRMETCFQQACKGKIQALCENPEWAPLKDNRIPSYGVLSVDLSLTVEL 268 Measles virus
4GJT_A    200 pvIDRLYLSSHRGVIADNQAKWAVPTTRTDDKLRMETCFQQACKGKNQALCENPEWAPLKDNRIPSYGVLSVNLSLTVEL 279 Measles virus stra...
3INB_A    193 pvIDRLYLSSHRGVIADNQAKWAVPTTRTDDKLRMETCFQQACKGKIQTLCENPEWAPLKDNRIPSYGVLSVDLSLTVEL 272 Measles virus stra...
3ALZ_A    199 pvIDRLYLSSHRGVIADNQAKWAVPTTRTDDKLRMETCFQQACKGKIQALCENPEWAPLKDNRIPSYGVLSVDLSLTVEL 278 Measles virus stra...
2ZB5_A    199 pvIDRLYLSSHRGVIADNQAKWAVPTTRTDDKLRMETCFQQACKGKIQALCENPEWAPLKDNRIPSYGVLSVDLSLTVEL 278 Measles virus stra...
3ALW_A    164 pvIDRLYLSSHRGVIADNQAKWAVPTTRTDDKLRMETCFQQACKGKIQALCENPEWAPLKDNRIPSYGVLSVDLSLTVEL 243
Q998P6    340 psVERIHITNHRGFIKDSVATWMVPALVSEQQEGQKNCLESACQRKSYPMCNQTSWEPFGGVQLPSYGRLTLPLDASIDL 419 Canine distemper v...
Q56TT1    340 ssIEKLYITSHRGIIRDSKARWSVPAIRSDDRTKMGKCTQALCKGRPPPSCNSSNWEPLTNNRIPAYAYIALEIKKDSDL 419 Porpoise morbilliv...
Q8B6X9    344 lmVEKLYLSSHRGIIKDNEANWVVPSTDVRDLQNKGECLVEACKTRPPSFCNGTGSGPWSEGRIPAYGVIRVSLDLASDP 423 Peste-des-petits-r...
P12567    344 ptLDGLYITTHRGIIAAGTAIWAVPVTRTDDQVKMGKCRLEACRDRPPPFCNSTDWEPLEAGRIPAYGVLTIKLGLADEP 423 Rinderpest virus (...
Feature 1                                             ##                 #                #  #
2RKC_A    269 KIKIASGFGPLITHGSGMDLYKSNHNNVYWLTIPPMKNLALGVINTLEWIPRFKVSPYLFTVPIKEAGEDCHAPTYLPAE 348 Measles virus
4GJT_A    280 KIKIASGFGPLITHGSGMDLYKTNHNNVYWLTIPPMKNLALGVINTLEWIPRFKVSPNLFTVPIKEAGEDCHAPTYLPAE 359 Measles virus stra...
3INB_A    273 KIKIASGFGPLITHGSGMDLYKSNHNNVYWLTIPPMKNLALGVINTLEWIPRFKVSPYLFTVPIKEAGEDCHAPTYLPAE 352 Measles virus stra...
3ALZ_A    279 KIKIASGFGPLITHGSGMDLYKSNHNNVYWLTIPPMKNLALGVINTLEWIPRFKVSPYLFTVPIKEAGGDCHAPTYLPAE 358 Measles virus stra...
2ZB5_A    279 KIKIASGFGPLITHGSGMDLYKSNHNNVYWLTIPPMKNLALGVINTLEWIPRFKVSPYLFTVPIKEAGGDCHAPTYLPAE 358 Measles virus stra...
3ALW_A    244 KIKIASGFGPLITHGSGMDLYKSNHNNVYWLTIPPMKNLALGVINTLEWIPRFKVSPYLFTVPIKEAGGDCHAPTYLPAE 323
Q998P6    420 QLNISFTYGPVILNGDGMDYYENPLLDSGWLTIPPKNGTILGLINKASRGDQFTVTPHVLTFAPRESSGNCYLPIQTSQI 499 Canine distemper v...
Q56TT1    420 ELDITSNYGPLIIHGVGMDIYEGPHNNQAWLAIPPLSQSVLGVINKVDFTTGFNVNPHTLTTAVEYGSEKCYAPVELSGA 499 Porpoise morbilliv...
Q8B6X9    424 GVVITSVFGPLIPHLSGMDLYNNPFSRAVWLAVPPYEQSFLGMINTIGFPNRAEVMPHILTTEIRGPRGRCHVPIELSRR 503 Peste-des-petits-r...
P12567    424 KVDIISEFGPLITHDSGMDLYTSFDGTKYWLTTPPLQNSALGTVNTLVLEPSLKISPNILTLPIRSGGGDCYTPTYLSDR 503 Rinderpest virus (...
Feature 1      #                                   # #   #  #                                 
2RKC_A    349 VDGDVKLSSNLVILPGQDLQYVLATYDTSRVEHAVVYYVYSPSRSFSYFYPFRLPIKGVPIELQVECFTWDQKLWCRHFC 428 Measles virus
4GJT_A    360 VDGDVKLSSNLVILPGQDLQYVLATYDTSRVEHAVVYYVYSPSRSFSYFYPFRLPIKGVPIELQVECFTWDKKLWCRHFC 439 Measles virus stra...
3INB_A    353 VDGDVKLSSNLVILPGQDLQYVLATYDTSRVEHAVVYYVYSPGRSFSYFYPFRLPIKGVPIELQVECFTWDQKLWCRHFC 432 Measles virus stra...
3ALZ_A    359 VDGDVKLSSNLVILPGQDLQYVLATYDTSRVEHAVVYYVYSPSRSFSYFYPFRLPIKGVPIELQVECFTWDQKLWCRHFC 438 Measles virus stra...
2ZB5_A    359 VDGDVKLSSNLVILPGQDLQYVLATYDTSRVEHAVVYYVYSPSRSFSYFYPFRLPIKGVPIELQVECFTWDQKLWCRHFC 438 Measles virus stra...
3ALW_A    324 VDGDVKLSSNLVILPGQDLQYVLATYDTSRVEHAVVYYVYSPSRSFSYFYPFRLPIKGVPIELQVECFTWDQKLWCRHFC 403
Q998P6    500 MDKDVLTESNLVVLPTQNFRYVVATYDISRENHAIVYYVYDPIRTISYTYPFRLTTKGRPDFLRIECFVWDDDLWCHQFY 579 Canine distemper v...
Q56TT1    500 KDQDLKLESNLVVLPTKDFGYVTATYDTSRSEHAIVYYVYDTARSSSYLFPFRIKARGEPLYLRIECFPWSRQLWCHHYC 579 Porpoise morbilliv...
Q8B6X9    504 VDDDIKIGSNMVILPTMDLRYITATYDVSRREHAIVCYIYDTGLSSSYYYPVRLNFKGNPLSLRIECFPWRHKVWCYHDC 583 Peste-des-petits-r...
P12567    504 ADDDVKLSSNLVILPSRDLQYVSATYDISRVEHAIVYHIYSTGRLSSYYYPFKLPIKGDPVSLQIECFPWDRKLWCHHFC 583 Rinderpest virus (...
Feature 1                       
2RKC_A    429 VLADSESGGHITHSGMVG 446 Measles virus
4GJT_A    440 VLADSESGGHITHSGMVG 457 Measles virus strain Ichinose-B95a
3INB_A    433 VLADSESGGHITHSGMVG 450 Measles virus strain Edmonston
3ALZ_A    439 VLADSESGGHITHSGMVG 456 Measles virus strain Edmonston-B
2ZB5_A    439 VLADSESGGHITHSGMVG 456 Measles virus strain Edmonston-B
3ALW_A    404 VLADSESGGHITHSGMVG 421
Q998P6    580 RFESDITNSTTSVEDLVR 597 Canine distemper virus
Q56TT1    580 MINSTMSSEIVVVDDLVS 597 Porpoise morbillivirus
Q8B6X9    584 LIYNTITDEEVHTRGLTG 601 Peste-des-petits-ruminants virus
P12567    584 SVIDSGTGEQVTHIGVVG 601 Rinderpest virus (strain Kabete O)

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