1E8V,2VSM,2RKC


Conserved Protein Domain Family
HN_like

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cd15464: HN_like 
Click on image for an interactive view with Cn3D
Haemagglutinin-neuraminidase (HN) of paramyxoviridae and similar proteins
Most paramyxoviridae have two membrane-anchored glycoproteins that mediate entry of the virus into the host cell. The protein characterized by this model is called hemagglutinin-neuraminidase (HN), hemagglutinin glycoprotein (H), or glycoprotein (G). Typically it has a variety of functions during viral infection; it participates in virus attachment to host cells, may cleave sialic acid off host oligosaccharides, and has a stimulating effect on membrane fusion during the entry of the virus into the host cell.
Statistics
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PSSM-Id: 271230
Aligned: 7 rows
Threshold Bit Score: 419.542
Created: 28-Mar-2013
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1: putative active site [active site], 6 residue positions
Conserved feature residue pattern:R E R R Y EClick to see conserved feature residue pattern help
Evidence:
  • None

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                         #                                                           
1E8V_A     37 LNFIPAPtt------gSGCTRIPSFDMSatHYCYTHNVILs-GCRDHs------HSHQYLALGVLRTtATGRIFFSTLRS 103 Newcastle disease ...
2VSM_A     17 SYTLPVVgq------sGTCITDPLLAMDegYFAYSHLERIg-SCSRGv------SKQRIIGVGEVLDrGDEVPSLFMTNV 83  Nipah virus
2RKC_A     46 MSLSLLDlyl----grGYNVSSIVTMTSqgMYGGTYLVEKp-ILSSKrselsqlSMYRVFEVGVIRNpGLGAPVFHMTNY 120 Measles virus
Q6WGM0    233 PAFIGTDtgi----liNSCVRQPVIATGdgIYALTYLTMRg-TCQDHr------HAVRHFEIGLVRRdAWWDPVLTPIHH 301 Mossman virus
ACL97359  224 LNLIPAMigtatgaliRNCVRQPVIVVDdgVYMLTYLAMRg-SCQDHq------KSVRHFEMGVITSdPFGDPVPTPLRH 296 Nariva virus
AFM97197  224 FALIGALpsq----lfNEFEGYPSLAIVseVYAITYLKGVmfENQEN-------FLYQYFEIGTISPdGYNKPYFLRHTS 292 Salem virus
AHM23777  207 PNLGPASsn------sDECYTNPSFSIGssIYMFSQEIRKt-DCTAGe------ILSIQIVLGRIVDkGQQGPQASPLLV 273 Mojiang virus
Feature 1                                                                                     
1E8V_A    104 ISLDDTQNRKSCSVSATPLGCDMLCSKVTETEEEDYNSAVPTLMAHGRLGf-------dGQYHEKDLDvttl--fedWVA 174 Newcastle disease ...
2VSM_A     84 WTPPNPNTVYHCSAVYNNEFYYVLCAVSTVGDPILNSTYWSGSLMMTRLAvkpksngggYNQHQLALRsie---kgrYDK 160 Nipah virus
2RKC_A    121 LEQPVSNDLSNCMVALGELKLAALCHGEDSITIPYQGSGKGVSFQLVKLGvw-----ksPTDMQSWVPlstd--dpvIDR 193 Measles virus
Q6WGM0    302 FTEPGTPVFDGCSLTVQNQTALALCTLTTDGPETDIHNGASLGLALVHFNi-------rGEFSKHKVDprnidtqnqGLH 374 Mossman virus
ACL97359  297 WTKRALPAYDGCALAVKGHAGFALCTETSVGPLRDRTAKRKPNIVLFKASl-------vGELSERVIPpqswlsgfsFFS 369 Nariva virus
AFM97197  293 VMLSTFKLSGKCTAAVDYRGGIFLCTPSPKIPKILQNPPDLPTLTVVSIPf-------dGRYTIRNISlmltdeadiIYD 365 Salem virus
AHM23777  274 WAVPNPKIINSCAVAAGDEMGWVLCSVTLTAASGEPIPHMFDGFWLYKLEp-------dTEVVSYRITgyaylldkqYDS 346 Mojiang virus
Feature 1                                                                                     
1E8V_A    175 NYPGVGGGSFIDGRVWFSVYGGLkpnspsdtvqegkyviykryndtcpdeqdyqirmakssykpGRFGGKRIQQAILSIK 254 Newcastle disease ...
2VSM_A    161 VMPYGPSGIKQGDTLYFPAVGFLvrtefkyndsncpitk----------cqyskpencrlsmgiRPNSHYILRSGLLKYN 230 Nipah virus
2RKC_A    194 LYLSSHRGVIADNQAKWAVPTTRtddklrmetcfqqac------------kgkiqalcenpewaPLKDNRIPSYGVLSVD 261 Measles virus
Q6WGM0    375 LVTTAGKSAVKKGILYSFGYMVTrspepgdskcvteec------------nqnnqekcnaysktTLDPDKPRSMIIFQID 442 Mossman virus
ACL97359  370 VYTVAGKGYAYHSKFHAFGNVVRvgqseyqakcrgtgc------------ptanqddcntaqrvSQEDNTYLHQAILSVD 437 Nariva virus
AFM97197  366 LDTLQGRGVLQAMRFYALVRVISsssprhfpfcknswc------------ptaddkicdqsrrlGADGNYPVMYGLISIP 433 Salem virus
AHM23777  347 VFIGKGGGIQKGNDLYFQMYGLSrnrqsfkalcehgsclg--------tggggyqvlcdravmsFGSEESLITNAYLKVN 418 Mojiang virus
Feature 1                            #                #                                       
1E8V_A    255 VstslgEDPVLTVPPNTVTLMGAEGRILTV--GTSHFLYQRGSSYFSPALLYPMTVsnktATLHSPYTFNaftrpg---- 328 Newcastle disease ...
2VSM_A    231 LsdgenPKVVFIEISDQRLSIGSPSKIYDS--LGQPVFYQASFSWDTMIKFGDVLTv--nPLVVNWRNNTvisrpg---- 302 Nipah virus
2RKC_A    262 LsltveLKIKIASGFGPLITHGSGMDLYKSnhNNVYWLTIPPMKNLALGVINTLEWi--pRFKVSPYLFTvpikeag--- 336 Measles virus
Q6WGM0    443 VgaeyfTVDKVVVVPRTQYYQLTSGDLFYTgeENDLLYQLHNKGWYNKPIRGRVTFd--gQVTLHEHSRTydslsn---- 516 Mossman virus
ACL97359  438 IdsvidPEDVVYVIERDQYYQASAGDLYRVpeTGEILYNLHNGGWSNEVQVGRIQPs--dRFYMREIQLTstrvpa---- 511 Nariva virus
AFM97197  434 AhssyqGNVSLKLIDPKYYAYTRDASLFYNsmTDTYHYSFGTRGWVSRPIIGELLLg--dDIVLTRYTVRsvsrat---- 507 Salem virus
AHM23777  419 DlasgkPVIIGQTFPPSDSYKGSNGRMYTI--GDKYGLYLAPSSWNRYLRFGITPDi--sVRSTTWLKSQdpimkilstc 494 Mojiang virus
Feature 1                                                       #                             
1E8V_A    329 --sipcqASARCPNSCVTGVYTDPYPLIFyrnhtlRGVFGTMLDSE--QARLNPASAVFDstSRSRITRVSSSs---tKA 401 Newcastle disease ...
2VSM_A    303 --qsqcpRFNTCPEICWEGVYNDAFLIDRi----nWISAGVFLDSN--QTAENPVFTVFKdnEILYRAQLASEd---tNA 371 Nipah virus
2RKC_A    337 -edchapTYLPAEVDGDVKLSSNLVILPGq----dLQYVLATYDTS--RVEHAVVYYVYSp-SRSFSYFYPFRlpikgVP 408 Measles virus
Q6WGM0    517 --qracnPRLGCPSTCELTSMASYFPLDK------DFKAAVGVIAL--RNGMTPIITYSTddWRNHWKYIKNAd---lEF 583 Mossman virus
ACL97359  512 --pngcnRVKGCPGGCVAVISPAFTPMHP------EFNVGVGIFPM--NQPHNPSIMHVQqqTELFWKPIVGGn---iTL 578 Nariva virus
AFM97197  508 --agdctTVSMCPQACSGGMNSIFYPLNFd----kPQVTGVAIRQYe-RQQEGIIVVTMNd-HYYYSVPIIKNg---tLL 576 Salem virus
AHM23777  495 tntdrdmCPEICNTRGYQDIFPLSEDSEY------YTYIGITPNNGgtKNFVAVRDSDGHi-ASIDILQNYYSi----TS 563 Mojiang virus
Feature 1      #                    #                     
1E8V_A    402 AYTTSTCFKvvktnKTYCLSIAEISNTlf----gEFRIVPLLVE 441 Newcastle disease virus
2VSM_A    372 QKTITNCFLlk--nKIWCISLVEIYDTgd----nVIRPKLFAVK 409 Nipah virus
2RKC_A    409 IELQVECFTwd--qKLWCRHFCVLADSes----gGHITHSGMVG 446 Measles virus
Q6WGM0    584 SESSLSCYSpnpplDDYVLCTAVITAKvm----sNTNPQLLATS 623 Mossman virus
ACL97359  579 HESSIACYStvppnPSYDLCIGVMTLL-------LHQGQLPQFQ 615 Nariva virus
AFM97197  577 ISSVTDCFWlm--gDLWCMSLMEKNNLplgvrslAHLTWNIHWS 618 Salem virus
AHM23777  564 ATISCFMYKd----EIWCIAITEGKKQkd----nPQRIYAHSYK 599 Mojiang virus

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