Conserved Protein Domain Family
NHL_like_3
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cd14956: NHL_like_3 
Uncharacterized NHL-repeat domain in bacterial proteins
The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Links
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Statistics
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PSSM-Id: 271326
Aligned: 20 rows
Threshold Bit Score: 301.509
Created: 27-Mar-2014
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1:NHL repeat [structural motif]
Evidence:
  • None
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                        #######     #####################     #######                    
EXJ14965       37 NIGSEGSDPGQFr-yVEDFALSk----DGHLLVTDASHAYVQVFDKTTgefisRFGGKGDEDDNl--eKPEGISVAp--- 106  Thiorhodococc...
YP_001768329   37 SIGTRGTEAGQFe-yVEDLALTr----DGRILATDAAHAWVQAFDKTTgrflgRFGGRGDEDHHl--eRPEGIAVDe--- 106  Methylobacter...
NP_869631      69 VWGRRGFSDGRFl-kPRAMAID-----PDDQLYIVDTTGRIQVFDADGqh--lRTWTTPETNNG----RPTGMVFDg--- 133  Rhodopirellul...
WP_020471328   31 VWGQRGVRDGDFv-rPRAAVID-----GQDRLWVVDFTARVQAFDLDGqy-lgPTFTTPDYRNG----RPSGLGVTn--- 96   Zavarzinella ...
CCH73235      232 SFGSEGSGPGQFkgdPRGITLSr---nGNIAFVTDDGNARIIAFSTTGttrgkQLYAIGGGTSKaf-iDPRGVDVTp--- 304  Tetrasphaera ...
YP_003370661   45 VWGRRGNSPGKFt-kPRAVTID-----AADNLYVVDTTPRIQVFTGDGem--lRNWQTPEFANG----KPSGLSMDr--- 109  Pirellula sta...
CCH75758      222 SFGSPGTGSGQFk-nPYGVRVAddpywGESVYVADSNNNRIQIFKTDGty-rtQLGRTGTSDEPgtftTLRRVAVAk--- 296  Tetrasphaera ...
WP_009098728   29 VWGRRGLSDGRFl-kPRAITID-----PDDQLYIVDTTGRIQVFDVDGch--lRTWKVPDTANG----RPTGLSFDsrpe 96   Rhodopirellul...
CCH75757      182 QFGGFGVKDGQIk-sPHGLALDa----NDNLYVVDTGNWRVSVFDKNGtf-lrKFGTKGSGAGQfa-gDMRGIAVNk--- 251  Tetrasphaera ...
CCH72229      192 AITGVGSEPGQFg-lLRGIAVDa----ASNTYVADTSKGLIQVFDASGaf-vrTIGARGDGPGKfr-gDMRGLAIDr--- 261  Tetrasphaera ...

Feature 1                                                                                         
EXJ14965      107 ---NGDIYVADytTGDVKVYDPSYSw----KATFSEYGEEPGq----nIKSEFTDiyDGRYYMPEAg-NHRVSVFDLEGN 174  Thiorhodococc...
YP_001768329  107 ---AGNVFVADhaSGFIKKYDPAFRw----LVTFGGYGAGAGq----tMRSEFMDihGGRLFVPEAg-THRVSVFDLDGA 174  Methylobacter...
NP_869631     134 --aKNRLLVADthYYRMLAFTPTGEll-peDQIGGTSGNGAGef--afVTDIAVDg-DGCLYIGEYgaSDRIQRFDPDGT 207  Rhodopirellul...
WP_020471328   97 ---DGRLMVCDshYHTLRIYDTDSNe---vQTIGGRSGNGPGef--gyLSDAVQDa-DGFFYVSEFgiNERITKLKADGS 167  Zavarzinella ...
CCH73235      305 ---DGLLLVADewDYSLKEYSFTSAgatlkRRLFGVRAPKTGan---sPRGVAVDa-KGNLFVSDWw-NQRIVRKDAATG 376  Tetrasphaera ...
YP_003370661  110 ---EGNLLVSDthYFRVLTYTPTGEll-kdRTIGGVCGHGEGef--gfVTDCVQDs-QGNYFVAEYgeFDRIQKFSPDRK 182  Pirellula sta...
CCH75758      297 ---DGDVWGADlwGWRLVRFDRSSSaftyaQTIGGNPPPATPgavfnePRAVAVSs-TGNLNIIDTv-NQRIVEMAPDGS 371  Tetrasphaera ...
WP_009098728   97 nptTPRLLVADthYYRMLVFDPDGElq-tdQQIGGKSGSADGef--afVTDAVCDa-EGNVYVGEYgaSDRIQKFSPDGQ 172  Rhodopirellul...
CCH75757      252 --tKGWVYVVDgeGNKISKFTLDGTf----INKWGSEGHGNGqfa-dgGREATVDa-KGNLWVADMp-NYRMQKFGPNGG 322  Tetrasphaera ...
CCH72229      262 --vNGWIYANDaeASQIEKFSLTGEh----LATFGSEGSGPGqfr-dgGRELTVGl-DGNVYAPDFg-GYRVLVFRPDGT 332  Tetrasphaera ...

Feature 1                                                                                         
EXJ14965      175 FLFIFGGPGt--ePGQMNNPESAKFNSe-GRLYLADLKNDRIQVFDKDG---NFLFTWGESgs-epGQFKAPAGIGIDAR 247  Thiorhodococc...
YP_001768329  175 HVRAFGRRGa--gPGEFDSPEAAKVSPd-GRLFVTDLRNDRLQVFDPEG---RLLAVWGRTgt-gpGEFRSPAGLGFDRD 247  Methylobacter...
NP_869631     208 FMAQWGGTGr--eVQHFVRPQSLVIHE--KTLWIADACNHRVQRYDISTtepRWIGSWGQEgk-qlGDFYYPYGIAVDPD 282  Rhodopirellul...
WP_020471328  168 FVKSWGKPGi--ePGEFNRPRALALGPd-GNLYVADGCNHRVQVFTRDG---DLVRVIGREgt-epGELKYPYDLAFGPK 240  Zavarzinella ...
CCH73235      377 AITTWGQRGirgeVMSLNFQWAVAVQPgtGHVFVANRESHEIKVFNNTGs--QQLFVWGSRns-qpGNFTFPQGLAFAPD 453  Tetrasphaera ...
YP_003370661  183 FLLQWGSPGg--eLMQFKRPQKLVIDDq-DQLWVTDACNHRVQVFDIRGnqvKLVAHWGQHgy-epGQLNYPYDILLDGQ 258  Pirellula sta...
CCH75758      372 IIGTCGQRDs--rPISLNWPRGVALDPvtGDRWVADTKQSRLQIFPAKCs--AQKIRVGTKgs-gtGEMNWPYSVAIRAA 446  Tetrasphaera ...
WP_009098728  173 FVASWGGTGe--aPGRFLRPQSLVVDG--QTLWIADACNHRIVRYDLAHqtpQMIGQWGTEgt-apGQLHYPYDLAVDRD 247  Rhodopirellul...
CCH75757      323 FLSAYPNPPqpppTGGFNAPRGVDVNPadGAVAVSDTYNWRIQTFTNAG---AFVDTWGERgr-gnYEFNYARLLKYSPA 398  Tetrasphaera ...
CCH72229      333 FLRSLPDPVppppPGGFNQAMGVAVNDstGAVYVADTYNQRIQQFTAAG---AFARQWGFRgstggYAMNYPRGVTVDQA 409  Tetrasphaera ...

Feature 1                                                                                
EXJ14965      248 -DRVYVSEIGNDRIQVFd-----kEGRYLTGWGSKGsg-dGEFGNLHGLFVDrsTGWVYVADTaNNRVQVF 311  Thiorhodococcus sp. AK35
YP_001768329  248 -GNVYVSEIGNSRVQVLg-----pDGRFLGMWGVPGsa-pGAFSNLHGVLVDrdTGLVYVADTgNFRIQVF 311  Methylobacterium sp. 4-46
NP_869631     283 -GTVLVCEFGNQRVQRLt-----pDGEPISSWGAPGhd-pGQLYEPWGLVVDs-RRRVHVLDSnNHRVQRF 345  Rhodopirellula baltica...
WP_020471328  241 -KQLYVVERGNHRVQRFt-----mDGVSEGVWGGKNgrlpGQLADPWGLVVDk-KGRVHVIDTeNHRVQRI 304  Zavarzinella formosa
CCH73235      454 -GTLWVADSGNSRVQQFrvnvankTATVLKAVGSAGtg-vGQFGMPTGISVDa-DGTVYVADTlNNRIQAY 521  Tetrasphaera australie...
YP_003370661  259 -GHVYLCEFGNHRVQKFt-----lDGKFLASWGTNGre-pGQLDQPWGIIQDs-RGRMYVLDSyNHRVQRF 321  Pirellula staleyi DSM ...
CCH75758      447 dRLAFVADTQNNRITVW-------DVASRKQIASYTg---AAMKQPRSVTVVegTNKIVVSDWgNNRVLEL 507  Tetrasphaera australie...
WP_009098728  248 -GSIVVCEYGNQRLQRFt-----eDGVCLGVWGSPGhe-pGQLYQPWGVVIDs-SGRVHVLDSnNHRVQRV 310  Rhodopirellula sp. SWK7
CCH75757      399 nQNIVIVDTDNGRVKAYa-----kDGTFLWSTGSAGtg-lGQFKNPQGLGIGk-DGTIYVADSnNRRIQVV 462  Tetrasphaera australie...
CCH72229      410 tGRVWVANSRQGNVKAYs-----aTGTFLRSFGRWGte-tGQYQLARDLVVR--GNRIYHADSnNLRIVAT 472  Tetrasphaera australie...

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