Conserved Protein Domain Family
NHL_like_4
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cd14955: NHL_like_4 
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins
The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Links
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Statistics
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PSSM-Id: 271325
Aligned: 44 rows
Threshold Bit Score: 361.894
Created: 21-Mar-2014
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1:NHL repeat [structural motif]
Evidence:
  • None
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                          ####### ############    #########        #####                 
NP_618713      36 FVKVIGSSGTGSNQFSsPKYATTDsSGNIYVADTGNN----RIEIFDKNFNYIDk--WGSGGSGn-GQFYTPNGVAVDSM 108  Methanosarcin...
YP_006621225   33 ASAFRPFIPAQQWFFEsPKAVAVD-GSDIYVGTSAGDispyQITKVSSTGELLEs--WGIQGSEn-GQIDELTDIAVDGD 108  Desulfosporos...
YP_006545817   31 FVTKWGEYGTGEGFKD-PFDIAIDtAGHIYITETDANhilqRILKLDSSMNFITk--WGSYGTGn-GQFNGPQGIAVNAA 106  Methanoculleu...
YP_006545780 1526 FMRRWESWHTGEIKFLyPAGIATDtVGDIYVADYYNH----RVQKFDSSGALISm--WGSYGSGn-GQFDRLTGIATDIS 1598 Methanoculleu...
WP_004040747 1437 SGDGEFGCDYDSYSENgPHGVVMDaAGNVYVADLYNN----RIQKFDANGTFITk--WGSYGSGd-GEFSDPRGITVDSA 1509 Methanofollis...
WP_004040747 1011 FISEWGSRGTADGEFTyPDGIVRDtAGNIYVVDYGND----RIQKFNRTGSFITk--WGSSGYSedGEFNMPHGIAVDSD 1084 Methanofollis...
WP_004040747 1732 SLPGELPVIEANGNFSfPKGVAIDgEGFVYVADSGNN----RIQKFDANGTFITkwgGWPVGYGd-GQFSGLRGIAVDED 1806 Methanofollis...
YP_006545775  345 KFTTWGFKDSRDGEFLrPFDIAVDaAGNVYVADEIHTcihpCIHKFDSSGKFLTr--WGIRGSGn-GMFWKVAGIAADDS 421  Methanoculleu...
YP_006545775   64 VMKWGTKAYTEDGAFDtPKGVAVDaAGNVYVADRGNN----RIQKFDSDGNLLAk--WGSHGKGd-GEFRQPSSIAVDAA 136  Methanoculleu...
YP_006546188   32 LIATWGSLGADDGRFNrPTGIAVDaEGNVYVADYCDR----IQKFDSTGAFLLQ---WGSSGSGd-GEFYQPDNIALDAD 103  Methanoculleu...

Feature 1                                                                                         
NP_618713     109 GNIYVADy---nNHRVQKLDSTGV-YISQCDSSTIGDgls-fyPVDLAVDSlDNVYVSDsrSNRIVKLNKDGNYLTQWGS 183  Methanosarcin...
YP_006621225  109 GNVYVADs---gNNRVQKFSSAGD-FIMMLESSGNAEyp--msPRGVAADSdGNIYVTYetDNRVEKFDSSGQVDSDWWN 182  Desulfosporos...
YP_006545817  107 GNVYVADt---yNHRIQKFDSSGN-LLTKWGSWGSGDgqf-syPDSVAVDAaGNVYVSDtnNGRIQKFDSDGTFLGKWGS 181  Methanoculleu...
YP_006545780 1599 GNVYVSDy---yNHRIQKFDSTGA-FLTTWGAYGTGNgqf-dkPWGIAVDTaGDIYVADynNHRIQKFDSAGTFITAWGS 1673 Methanoculleu...
WP_004040747 1510 GYLYVSDy---wNNRIQKFDSSGTfITKFVFSQGSGDgqfglgPDSVAVDRaGNLYVTDpiNSRIQKFDNSGTFIAAWGS 1586 Methanofollis...
WP_004040747 1085 SNVYVTDt---wNSRIQKFDSTGT-FIAKWGSYGTGDgqf-dfPQGITIDAdGSIYVADnaNQRIQKFDSNGTFITKWGS 1159 Methanofollis...
WP_004040747 1807 GFIYVADaeeyvIARIQKFDSNGT-FITKWGSYGTGAgef-mdPQGVATDPfGNVYVTDgyGGRIQKFDISGTFIATWVS 1884 Methanofollis...
YP_006545775  422 GNVYVTDc---hSPRIQKFDSAGN-FLMKWGSYGTGDgei-lgASGIKTDAsGNVYVADpgNGRIQKFNSAGNFLMKWGS 496  Methanoculleu...
YP_006545775  137 GNVYVTDv---gNNRIQIFDSAGN-FLMKWEPCGTGDaef-wgVCSIAVDVsGNIYVVNedDYYIQKFDRSGKLLTKWGS 211  Methanoculleu...
YP_006546188  104 GKVYVVD-----YYRIQVFDSNGT-FLKKWGSYGTGEeql-qyPQSIAFDAdGNAYVIA--GGGIKKFDSDGNFLTSWGG 174  Methanoculleu...

Feature 1                                                                                         
NP_618713     184 kgasrnqFNDPEGIAVDSSGNIYVVDs----gNSRIMKFDGTGTYLTEWGTPgqed-gqfrSPHGIAIDSSGAIYVTDTg 258  Methanosarcin...
YP_006621225  183 qaagdyqFSQPTDIAVDKDGNVYVADt----dMGRIVQFTSAGDLLLMFGEEdedgedqliEPIGVAVDSSGNVYAVDAh 258  Desulfosporos...
YP_006545817  182 wgsgdgqLRFSQDLVVDAAGNIYVAEy----gNHRIQKFDSNGNFLWKKGSSgsgd-gqflSPYGITVDAAGNVYVADTw 256  Methanoculleu...
YP_006545780 1674 egsgsgqFNGPICIAVDAAGYIYVSDd----yNNRVQKFDSAGTFITAWGSEgtds-gqfsSLVGIAVDSAGHVFVVDHl 1748 Methanoculleu...
WP_004040747 1587 ygagigqFRSPTGIAVDADSNVYVADs----lNNRIQKFSSTGTFLTSWGLRgtgd-gefeEPRGIVVDAESHVYVTDHy 1661 Methanofollis...
WP_004040747 1160 ggtgdgeFDRPHGIVVDADGNVFVSDa----gNNNIQKFTSTGTFITKWGTAgsgd-gqfnVPRGIAVDSRGNVFVADSl 1234 Methanofollis...
WP_004040747 1885 ddkgvgqLLSPSCIATDDAGNVYVTSfdlytaSSDIRKFTGNGIFITTWGVSgsgd-gefsGLLGVAVNGDGLVYAADEy 1963 Methanofollis...
YP_006545775  497 ygtgngeFMWPKGIAVDASGNIYVTDy----hSSHIQKFDSAGNFLTKWGSYgrgd-gefrNPSGVAIDAAGNVYVADKe 571  Methanoculleu...
YP_006545775  212 rgt-geePWEVAGIAVDDSGNIYATDw----rHRCIQKFNSSGNFLTKWELHgldd-avyvAPTGIAVDTSGNVYVYDV- 284  Methanoculleu...
YP_006546188  175 fgtydgeFHNAVDVVVDAAGNVYVADc----yNNRIQMFNSTGAFLLKWQVG---------YPYGITVDSAGDVLVAASs 241  Methanoculleu...

Feature 1                                                                    
NP_618713     259 nRRIQKFdstg--syvtKWVSpen-gdGKFQNPVGIVVDSsNNVYVVDSfYHCVFQFVK 314  Methanosarcina acetivorans C2A
YP_006621225  259 tKQILKFnasg--nlllNWGGegr-ddDQFDDPCSIAVDSgDQIYVADSeNNRIQKFAS 314  Desulfosporosinus meridiei DSM 13257
YP_006545817  257 nHRIQKFdssg--nfltKWGSrgs-gnGQFSEPFGVAVDSaGNVYVTERgNDRVQMFAP 312  Methanoculleus bourgensis MS2
YP_006545780 1749 nCRIQKFdssg--tfisTWGSegf-sdGQFYRPSGIALDSaGNVYVADTySNRIQKFSP 1804 Methanoculleus bourgensis MS2
WP_004040747 1662 nNRIQKFdssg--tfitTWGSepp-gdSEFSYPKGVAVDDaGNVYVADTnNHRIQKFDA 1717 Methanofollis liminatans
WP_004040747 1235 nHRIQIFdtng--tfltEFGSygt-geGEFNEPWDTLVDNaGNVYVTDArNHRIQIFEP 1290 Methanofollis liminatans
WP_004040747 1964 nNRIQVFrsyt--patpPVAAfi---aNVTSGSAPLAVQF-TDTSTGNP-ASWVWNFGD 2015 Methanofollis liminatans
YP_006545775  572 nHRIQKFdsdg--tpltKWGSygg-gdGEFRQPSGVAVDAaGNVYVADRgNGRIQMFAP 627  Methanoculleus bourgensis MS2
YP_006545775  285 -SYIQKFdssgnflaqrESGGwvdgrfLPSSSAAGIAVDAtGNIYVANKdHCCIQKFDS 342  Methanoculleus bourgensis MS2
YP_006546188  242 -TSVLKFd---------SFGNll--arSLGGSGKDITVGAdGTVYVTSDhCVRVFKQSS 288  Methanoculleus bourgensis MS2

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