1SZ7,3CUE,2J3R,2CFH,2J3W,3CUE


Conserved Protein Domain Family
TRAPPC_bet3-like
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cd14941: TRAPPC_bet3-like 
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Bet3-like domains of TRAPP
Bet3-like domains of a subfamily of core components of the trafficking protein particle complex (TRAPP) include TRAPPC3, TRAPPC5, and TRAPPC6A. TRAPP complexes play a key role in the regulation of ER-to-Golgi and intra-Golgi transport by tethering the vesicle membrane to the target membrane. TRAPPs are large multimeric protein complexes which contain six core subunits that belong to two distinct structural families, the bet3-like family and the sedlin-like family.
Links
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Statistics
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PSSM-Id: 271344
Aligned: 6 rows
Threshold Bit Score: 186.514
Created: 22-Dec-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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heterodimer
Conserved site includes 16 residues -Click on image for an interactive view with Cn3D
Feature 1:heterodimer interface [polypeptide binding site]
Evidence:
  • Structure:2CFH; Homo sapiens Bet3-Tpc6B core of TRAPP, contacts 4A
  • Structure:2J3W: Danio rerio Bet3-trs31-sedlin Complex; contacts 4A
  • Structure:3CUE; Saccharomyces cerevisiae TRAPP membrane-tethering complexes; contacts 4A
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        ## ##  ##   ##               #   #   #  ##  ##                               
1SZ7_A     24 SSELFTLTYGALVTQLCkdye----ndeDVNKQLDKMGFNIGVRLIEDFLar---------------------------- 71  human
3CUE_D     26 NTELFTLTYGSIVAQLCqdye---rdfnKVNDHLYSMGYNIGCRLIEDFLar---------------------------- 74  baker's yeast
2J3R_B      6 SVSAFALLFSEMVQYCQsrvy----svsELQARLADMGQGVGASLLDVLVmre--------------------------- 54  zebrafish
2CFH_C      3 DEALFLLLHNEMVSGVYksaeqgevengRXITKLENMGFRVGQGLIERFTk----------------------------- 53  human
2J3W_B     25 SVSAFALLFSEMVQYCQsrvy----svsELQARLADMGQGVGASLLDVLVmre--------------------------- 73  zebrafish
3CUE_B     58 SLSAMAFLFQEMISQLHrtck----tagDFETKLSDYGHNIGIRLLELLNfrasvspsslprasaflsqnesssklsnas 133 baker's yeast

Feature 1                                                                                     
1SZ7_A     72 ----------------------------------snVGRCHDFRETADVIaKVAFKMyLGITPSITNWspa-gdEFSLIL 116 human
3CUE_D     75 ----------------------------------taLPRCENLVKTSEVLsKCAFKIfLNITPNITNWshn-kdTFSLIL 119 baker's yeast
2J3R_B     55 ----------------------------------knGKRETKVLNILLFIkVNVWKAlFGKEADKLEQandddkTYYIIE 100 zebrafish
2CFH_C     54 -----------------------------------dTARFKDELDIMKFIcKDFWTTvFKKQIDNLRTnh--qgIYVLQD 96  human
2J3W_B     74 ----------------------------------knGKRETKVLNILLFIkVNVWKAlFGKEADKLEQandddkTYYIIE 119 zebrafish
3CUE_B    134 nspgmlansstatsasanerlqekqteslsnyitkmRRRDLKILDILQFIhGTLWSYlFNHVSDDLVKsserdnEYMIVD 213 baker's yeast

Feature 1                             #                                     
1SZ7_A    117 ENNPlvdfvelp--dnhssliYSNLLCGVLRGALEMvqmAVEAKFVQDtlkg-dgvTEIRMR 175 human
3CUE_D    120 DENPladfvelp-mdamkslwYSNILCGVLKGSLEMvqlDCDVWFVSDilrg-dsqTEIKVK 179 baker's yeast
2J3R_B    101 KEPLinayisvp--kenstlnCAAFTGGIVEAILTHsgfPAKVTVHWHk------gTTLMIK 154 zebrafish
2CFH_C     97 NKFRlltqmsagkqylehaskYLAFTCGLIRGGLSNlgiKSIVTAEVSsm----paCKFQVM 154 human
2J3W_B    120 KEPLinayisvp--kenstlnCAAFTGGIVEAILTHsgfPAKVTVHWHk------gTTLMIK 173 zebrafish
3CUE_B    214 NFPTltqfip------genvsCEYFVCGIIKGFLFNagfPCGVTAHRMpqgghsqrTVYLIQ 269 baker's yeast

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