Conserved Protein Domain Family
MYSc_Myh18
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cd14932: MYSc_Myh18 
class II myosin heavy chain 18, motor domain
Myosin motor domain of muscle myosin heavy chain 18. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.
Links
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Statistics
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PSSM-Id: 276895
Aligned: 8 rows
Threshold Bit Score: 1367.02
Created: 7-Jan-2013
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1:ATP binding site [chemical binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                    #########                                           #
AAH45324       93 ASVLHNLRERYYSGLIYTYSGLFCVVINPYKYLPIYTEKIVEMYKGKKRHEMPPHIYAITDTAYRSMMQDREDQSILCTG 172  zebrafish
AAH60675       93 ASVLHNLRERYYSGLIYTYSGLFCVVINPYKYLPIYTEEIVEMYKGKKRHEMPPHIYAITDTAYRSMMQDREDQSILCTG 172  zebrafish
AAI29314       93 ASVLHNLRERYYSGLIYTYSGLFCVVINPYKYLPIYTEEIVEMYKGKKRHEMPPHIYAITDTAYRSMMQDREDQSILCTG 172  zebrafish
NP_001091647   93 ASVLHNLRERYYSGLIYTYSGLFCVVINPYKYLPIYTEEIVEMYKGKKRHEMPPHIYAITDTAYRSMMQDREDQSILCTG 172  zebrafish
XP_003447953   93 ASVLHNLKERYYSGLIYTYSGLFCVVINPYKHLPIYSEEIVNMYKGKKRHEMPPHIYAITDTAYRSMMQDREDQSILCTG 172  Nile tilapia
XP_003972149   93 ASVLHNLKERYYSGLIYTYSGLFCVVVNPYKHLPIYSEDIVNMYKGKKRHEMPPHIYAITDTAYRSMMQDREDQSILCTG 172  torafugu
XP_004065556   93 ASVLHNLKERYYSGLIYTYSGLFCVVINPYKHLPIYSEEIVNMYKGKKRHEMPPHIYAITDSAYRSMMQDREDQSILCTG 172  Japanese medaka
XP_005797606   93 ASVLHNLKERYYSGLIYTYSGLFCVVINPYKNLPIYSEEIVNMYKGKKRHEMPPHIYAITDTAYRSMMQDREDQSILCTG 172  southern plat...

Feature 1         #######                                                 ###########             
AAH45324      173 ESGAGKTENTKKVIQYLAYVASSFKTKKDQssialshGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVNG 252  zebrafish
AAH60675      173 ESGAGKTENTKKVIQYLAYVASSFKTKKDQssialshGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVNG 252  zebrafish
AAI29314      173 ESGAGKTENTKKVIQYLAYVASSFKTKKDQssialshGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVNG 252  zebrafish
NP_001091647  173 ESGAGKTENTKKVIQYLAYVASSFKTKKDQssialshGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVNG 252  zebrafish
XP_003447953  173 ESGAGKTENTKKVIQYLAHVASSFKSKKDQgsavlshGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVNG 252  Nile tilapia
XP_003972149  173 ESGAGKTENTKKVIQYLAYIASSFKSKKDQgsavlshGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVNG 252  torafugu
XP_004065556  173 ESGAGKTENTKKVIQYLAHVASSFKSKKDQ-------GELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVTG 245  Japanese medaka
XP_005797606  173 ESGAGKTENTKKVIQYLAHVASSSKFKKDQagavlshGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVNG 252  southern plat...

Feature 1                                                                                         
AAH45324      253 YIVGANIETYLLEKSRAIRQAKDERAFHIFYYLLTGAGDKLRSELCLEDYNKYRFLSNGNVTIPGQQDRELFAETIDAFR 332  zebrafish
AAH60675      253 YIVGANIETYLLEKSRAIRQAKDERAFHIFYYLLTGAGDKLRSELCLEDYNKYRFLSNGNVTIPGQQDRELFAETIDAFR 332  zebrafish
AAI29314      253 YIVGANIETYLLEKSRAIRQAKDERAFHIFYYLLTGAGDKLRSELCLEDYNKYRFLSNGNVTIPGQQDRELFVETIDAFR 332  zebrafish
NP_001091647  253 YIVGANIETYLLEKSRAIRQAKDERAFHIFYYLLTGAGDKLRSELCLEDYNKYRFLSNGNVTIPGQQDRELFAETIDAFR 332  zebrafish
XP_003447953  253 YIVGANIETYLLEKSRAVRQAKDERSFHIFYYMLTGAGEKLRSELCLEDYSKYRFLSNGHVTIPGQQDKDLYAETMEAFN 332  Nile tilapia
XP_003972149  253 YIVGANIETYLLEKSRAIRQAKEERSFHIFYYLLTGAGDKLRSELCLEDYSKYRFLSNGNMTIPGLQDKELFAETMEAFH 332  torafugu
XP_004065556  246 YIVGANIETYLLEKSRGIRQAKDERSFHIFYYMLSGAGDKMRADLLLEDFSKYRFLSNGKVTIPGQQDKDLFNETMEAFN 325  Japanese medaka
XP_005797606  253 YIVGANIETYLLEKSRAIRQAKEERAFHIFYYMLTGAGDKMRSDLCLEDYSKYRFLSNGKVTIPGQTDKELFVETMEAFN 332  southern plat...

Feature 1                                                                                         
AAH45324      333 IMGIPEDEQTGLLKVVSAVLQLGNMSFKKERNSDQASMPDDTAAQKVSHLLGMNVTDFTRAILSPRIKVGRDFVQKAQTQ 412  zebrafish
AAH60675      333 IMGIPEDEQTGLLKVVSAVLQLGNMSFKKERNSDQASMPDDTAAQKVSHLLGMNVTDFTRAILSPRIKVGRDFVQKAQTQ 412  zebrafish
AAI29314      333 IMGIPEDEQTGLLKVVSAVLQLGNMSFKKERNSDQASMPDDTAAQKVSHLLGMNVTDFTRAILSPRIKVGRDFVQKAQTQ 412  zebrafish
NP_001091647  333 IMGIPEDEQTGLLKVVSAVLQLGNMSFKKERNSDQASMPDDTAAQKVSHLLGMNVTDFTRAILSPRIKVGRDFVQKAQTQ 412  zebrafish
XP_003447953  333 IMSIPDEEITGLLKVVSAVLQLGNMTFKKERNSDQASMPDDTAAQKVCHLLGINVTDFTRAILSPRIKVGRDYVQKAQTQ 412  Nile tilapia
XP_003972149  333 IMSIPEEERIGFLKVVSAVLQLGNMTFKKERHSDQASMPDDTAAQKVCHLLSVNVTDFTRAILSPRIKVGRDYVQKAQTQ 412  torafugu
XP_004065556  326 IMSIPEEESTGLLKVVSAVLQLGNMSFKKERNSDQASMPDDTAAQKVCHLLGINVTDFTRAILSPRIKVGRDYVQKAQTQ 405  Japanese medaka
XP_005797606  333 IMSIPEEEINGLLKVISAVLQLGNMVFKKERNSDQASMPDDTAAQKVCHLLGINVTDFTRAILSPRIKVGRDYVQKAQTQ 412  southern plat...

Feature 1                                                     ######                              
AAH45324      413 EQAEFAVEALAKATYERLFRWLVMRINKALDKTKRQGASFIGILDIAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFIL 492  zebrafish
AAH60675      413 EQAEFAVEALAKATYERLFRWLVMRINKALDKTKRQGASFIGILDIAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFIL 492  zebrafish
AAI29314      413 EQAEFAVEALAKATYERLFRWLVMRINKALDKTKRQGASFIGILDIAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFIL 492  zebrafish
NP_001091647  413 EQAEFAVEALAKATYERLFRWLVMRINKALDKTKRQGASFIGILDIAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFIL 492  zebrafish
XP_003447953  413 EQAEFAVEALAKASYERMFRWLVMRINKALDKTKRQGASFIGILDIAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFIL 492  Nile tilapia
XP_003972149  413 EQAEFAVEALAKASYERMFRWLVFRINKALDKTKRQGASFIGILDIAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFIL 492  torafugu
XP_004065556  406 EQAEFAVEALAKASYERMFRWLVLRINRALDKTKRQGASFIGILDIAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFIL 485  Japanese medaka
XP_005797606  413 EQAEFAVEALAKASYERMFRWLVMRINKALDKTKRQGASFIGILDIAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFIL 492  southern plat...

Feature 1                                                                                         
AAH45324      493 EQEEYQREGIEWSFIDFGLDLQPCIELIEKPNGPPGILALLDEECWFPKATDKSFVEKVVQELGNNPKFQKPKKLKDDAD 572  zebrafish
AAH60675      493 EQEEYQREGIEWSFIDFGLDLQPCIELIEKPNGPPGILALLDEECWFPKATDKSFVEKVVQELGNNPKFQKPKKLKDDAD 572  zebrafish
AAI29314      493 EQEEYQREGIEWSFIDFGLDLQPCIELIEKPNGPPGILALLDEECWFPKATDKSFVEKVVQELGNNPKFQKPKKLKDDAD 572  zebrafish
NP_001091647  493 EQEEYQREGIEWSFIDFGLDLQPCIELIEKPNGPPGILALLDEECWFPKATDKSFVEKVVQELGNNPKFQKPKKLKDDAD 572  zebrafish
XP_003447953  493 EQEEYQREGIEWSFIDFGLDLQPCIDLIEKPAGPPGILALLDEECWFPKATDKSFVEKVSQEQGSHPKFQKPKKLKDDAD 572  Nile tilapia
XP_003972149  493 EQEEYQREGIEWSFIDFGLDLQPCIELIDKPAGPPGILALLDEECWFPKATDKSFVEKVVQEQGTHPKFQKPKKLKDDVD 572  torafugu
XP_004065556  486 EQEEYQREGIEWSFIDFGLDLQPCIDLIERPAGPPGILALLDEECWFPKATDKSFVEKVAQEQGNHPKFQKPKKLKDDAD 565  Japanese medaka
XP_005797606  493 EQEEYQREGIEWSFIDFGLDLQPCIDLIEKPNGPPGVLALLDEECWFPKATDKTFVEKLAQEQGTNPKFVKPKKLKDDAD 572  southern plat...

Feature 1                                                                                         
AAH45324      573 FCIIHYAGKVDYKANEWLMKNMDPLNDNVATLLNQSVDKFVSELWKDVDRIVGLDKVAGMgeSLHGAVKTRKGMFRTVGQ 652  zebrafish
AAH60675      573 FCIIHYAGKVDYKANEWLMKNMDPLNDNVATLLNQSVDKFVSELWKDVDRIVGLDKVAGMgeSLHGAVKTRKGMFRTVGQ 652  zebrafish
AAI29314      573 FCIIHYAGKVDYKANEWLMKNMDPLNDNVATLLNQSVDKFVSELWKDVDRIVGLDKVAGMgeSLHGAVKTRKGMFRTVGQ 652  zebrafish
NP_001091647  573 FCIIHYAGKVDYKANEWLMKNMDPLNDNVATLLNQSVDKFVSELWKDVDRIVGLDKVAGMgeSLHGAVKTRKGMFRTVGQ 652  zebrafish
XP_003447953  573 FCIIHYAGKVDYKANAWLMKNMDPLNECVATLLNQSTDKFTCDLWRDVDRIVGLDKVAGMsdSAQGAFKTRKGMFRTVGQ 652  Nile tilapia
XP_003972149  573 FCIIHYAGKVDYKADEWLMKNMDPLNESVATLLNQSTDKFTAELWRDMDHIVGLDKVAGMsdSTYGAFKTRKGMFRTVGQ 652  torafugu
XP_004065556  566 FCIIHYAGKVDYKANEWLMKNMDPLNESVATLLNQSTDKFTADLWKDVDRIVGLDKVAGMsdSAHGAFKTRKGMFRTVGQ 645  Japanese medaka
XP_005797606  573 FCIIHYAGKVDYKANEWLMKNMDPLNECVATLLNQSTDKFIGDLWRDVDRIVGLDKVAGM--ADSGPFKTRKGMFRTVGQ 650  southern plat...

Feature 1                                                                                         
AAH45324      653 LYKEQLMNLMTTLRNTNPNFVRCIIPNHEKKAGKLAHHLVLDQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILTPNA 732  zebrafish
AAH60675      653 LYKEQLMNLMTTLRNTNPNFVRCIIPNHEKKAGKLAHHLVLDQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILTPNA 732  zebrafish
AAI29314      653 LYKEQLMNLMTTLRNTNPNFVRCIIPNHEKKAGKLAHHLVLDQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILTPNA 732  zebrafish
NP_001091647  653 LYKEQLMNLMTTLRNTNPNFVRCIIPNHEKKAGKLAHHLVLDQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILTPNA 732  zebrafish
XP_003447953  653 LYKEQLTNLMTTLRNTNPNFVRCIIPNHEKKAGKLEAHLVLEQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILTPTA 732  Nile tilapia
XP_003972149  653 LYKEQLGNLMTTLRNTNPNFVRCIIPNHEKKAGKLEPHLVLDQLRCNGVLEGIRICRQGFPNRVVFQEFRQRYEILTPNA 732  torafugu
XP_004065556  646 LYKEQLGNLMTTLRNTNPNFVRCIIPNHEKKAGKLEPHLVLEQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILTPNA 725  Japanese medaka
XP_005797606  651 LYKEQLGNLMTTLRNTNPNFVRCIIPNHEKKAGKLDAHLVLDQLSCNGVLEGIRICRQGFPNRIVFQEFRQRYEILTPNA 730  southern plat...

Feature 1                                             
AAH45324      733 IPKGFMDGKQACVLMVKALELDSNLYRIGQSKVFFR 768  zebrafish
AAH60675      733 IPKGFMDGKQACVLMVKALELDSNLYRIGQSKVFFR 768  zebrafish
AAI29314      733 IPKGFMDGKQACVLMVKALELDSNLYRIGQSKVFFR 768  zebrafish
NP_001091647  733 IPKGFMDGKQACVLMVKALELDSNLYRIGQSKVFFR 768  zebrafish
XP_003447953  733 IPKGFMDGKQACVLMIKALELDPNLYRIGQSKVFFR 768  Nile tilapia
XP_003972149  733 IPKGFMDGKQACVLMIKALELDPNLYRIGQSKVFFR 768  torafugu
XP_004065556  726 IPKGFMDGKQACVLMVKALELDPNLYRIGQSKVFFR 761  Japanese medaka
XP_005797606  731 IPKGFMDGKQACVLMIKALELDPNLYRIGQSKVFFR 766  southern platyfish

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