Conserved Protein Domain Family
MYSc_Myh14_mammals
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cd14930: MYSc_Myh14_mammals 
class II myosin heavy chain 14 motor domain
Myosin motor domain of non-muscle myosin heavy chain 14 (also called FLJ13881, KIAA2034, MHC16, MYH17). Its members include mammals, chickens, and turtles. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. Some of the data used for this classification were produced by the CyMoBase team at the Max-Planck-Institute for Biophysical Chemistry. The sequence names are composed of the species abbreviation followed by the protein abbreviation and optional protein classifier and variant designations.
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Statistics
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PSSM-Id: 276893
Aligned: 21 rows
Threshold Bit Score: 1302.76
Created: 8-Jan-2013
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1:ATP binding site [chemical binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                    #########                                           #
Q6URW6        115 ASVLHNLRERYYsgliYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPHVYAVTEGAYRSMLQDREDQsILCTG 194  house mouse
NP_082297     115 ASVLHNLRERYYsgliYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPHVYAVTEGAYRSMLQDREDQsILCTG 194  house mouse
EDL22740      115 ASVLHNLRERYYsgliYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPHVYAVTEGAYRSMLQDREDQsILCTG 194  house mouse
EDL22741      117 ASVLHNLRERYYsgliYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPHVYAVTEGAYRSMLQDREDQsILCTG 196  house mouse
EDM07465      115 ASVLHNLRERYYsgliYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPHIYAVTEGAYRSMLQDREDQsILCTG 194  Norway rat
NP_001094160  115 ASVLHNLRERYYsgliYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPHIYAVTEGAYRSMLQDREDQsILCTG 194  Norway rat
NP_001139281  119 ASVLHNLRERYYsgliYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPHVYAVTEGAYRSMLQDREDQsILCTG 198  human
DAA19711      120 ASVLHNLRERYYsgliYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPHVYAVTEGAYRSMLQDREDQsILCTG 199  cattle
NP_001258469  115 ASVLHNLRERYYsgliYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPHVYAVTEGAYRSMLQDREDQsILCTG 194  house mouse
JAA50065      120 ASVLHNLRERYYsgliYTYSGLFCVVINPYKQLPIYTESIVEMYRGKKRHEVPPHVYAVTEGAYRSMLQDREDQsILCTG 199  common vampir...

Feature 1         #######                                                     ###########         
Q6URW6        195 ESGAGKTENTKKVIQYLAHVASSPKGRKEPGVPasvstmsyGELERQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINF 274  house mouse
NP_082297     195 ESGAGKTENTKKVIQYLAHVASSPKGRKEPGVP--------GELERQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINF 266  house mouse
EDL22740      195 ESGAGKTENTKKVIQYLAHVASSPKGRKEPGVP--------GELERQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINF 266  house mouse
EDL22741      197 ESGAGKTENTKKVIQYLAHVASSPKGRKEPGVP--------GELERQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINF 268  house mouse
EDM07465      195 ESGAGKTENTKKVIQYLAHVASSPKGRKEPGVP--------GELERQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINF 266  Norway rat
NP_001094160  195 ESGAGKTENTKKVIQYLAHVASSPKGRKEPGVPasvstmsyGELERQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINF 274  Norway rat
NP_001139281  199 ESGAGKTENTKKVIQYLAHVASSPKGRKEPGVPasvstvsyGELERQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINF 278  human
DAA19711      200 ESGAGKTENTKKVIQYLAHVASSPKGRKEPGVPpspd-alqGELERQLLQANPVLEAFGNAKTVKNDNSSRFGKFIRINF 278  cattle
NP_001258469  195 ESGAGKTENTKKVIQYLAHVASSPKGRKEPGVPasvstmsyGELERQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINF 274  house mouse
JAA50065      200 ESGAGKTENTKKVIQYLAHVASSPKGRKEPGVPasasamsyGELERQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINF 279  common vampir...

Feature 1                                                                                         
Q6URW6        275 DIAGYIVGANIETYLLEKSRAIRQAKDECSFHIFYQLLGGAGEQLKADLLLEPCSHYRFLTNGPSSSPGQERELFQETLE 354  house mouse
NP_082297     267 DIAGYIVGANIETYLLEKSRAIRQAKDECSFHIFYQLLGGAGEQLKADLLLEPCSHYRFLTNGPSSSPGQERELFQETLE 346  house mouse
EDL22740      267 DIAGYIVGANIETYLLEKSRAIRQAKDECSFHIFYQLLGGAGEQLKADLLLEPCSHYRFLTNGPSSSPGQERELFQETLE 346  house mouse
EDL22741      269 DIAGYIVGANIETYLLEKSRAIRQAKDECSFHIFYQLLGGAGEQLKADLLLEPCSHYRFLTNGPSSSPGQERELFQETLE 348  house mouse
EDM07465      267 DIAGYIVGANIETYLLEKSRAIRQAKDECSFHIFYQLLGGAGEQLKADLLLEPYSHYRFLTNGPSSSPGQERELFQETLE 346  Norway rat
NP_001094160  275 DIAGYIVGANIETYLLEKSRAIRQAKDECSFHIFYQLLGGAGEQLKADLLLEPYSHYRFLTNGPSSSPGQERELFQETLE 354  Norway rat
NP_001139281  279 DVAGYIVGANIETYLLEKSRAIRQAKDECSFHIFYQLLGGAGEQLKADLLLEPCSHYRFLTNGPSSSPGQERELFQETLE 358  human
DAA19711      279 DVAGYIVGANIETYLLEKSRAIRQAKDECSFHIFYQLLGGAGEQLKADLLLEPFSHYRFLTNGPSSSPGQERELFQETLE 358  cattle
NP_001258469  275 DIAGYIVGANIETYLLEKSRAIRQAKDECSFHIFYQLLGGAGEQLKADLLLEPCSHYRFLTNGPSSSPGQERELFQETLE 354  house mouse
JAA50065      280 DVAGYIVGANIETYLLEKSRAIRQAKDECSFHIFYQLLGGAGEQLKADLLLEPFSHYRFLTNGPASSPGQERELFQETLE 359  common vampir...

Feature 1                                                                                         
Q6URW6        355 SLRVLGLLPEEITAMLRTVSAVLQFGNIVLKKERNTDqatMPDNTAAQKLCRLLGLGVTDFSRALLTPRIKVGRDYVQKA 434  house mouse
NP_082297     347 SLRVLGLLPEEITAMLRTVSAVLQFGNIVLKKERNTDqatMPDNTAAQKLCRLLGLGVTDFSRALLTPRIKVGRDYVQKA 426  house mouse
EDL22740      347 SLRVLGLLPEEITAMLRTVSAVLQFGNIVLKKERNTDqatMPDNTAAQKLCRLLGLGVTDFSRALLTPRIKVGRDYVQKA 426  house mouse
EDL22741      349 SLRVLGLLPEEITAMLRTVSAVLQFGNIVLKKERNTDqatMPDNTAAQKLCRLLGLGVTDFSRALLTPRIKVGRDYVQKA 428  house mouse
EDM07465      347 SLRVLGLLPEEITAMLRTVSAVLQFGNIVLKKERNTDqatMPDNTAAQKLCRLLGLGVTDFSRALLTPRIKVGRDYVQKA 426  Norway rat
NP_001094160  355 SLRVLGLLPEEITAMLRTVSAVLQFGNIVLKKERNTDqatMPDNTAAQKLCRLLGLGVTDFSRALLTPRIKVGRDYVQKA 434  Norway rat
NP_001139281  359 SLRVLGFSHEEIISMLRMVSAVLQFGNIALKRERNTDqatMPDNTAAQKLCRLLGLGVTDFSRALLTPRIKVGRDYVQKA 438  human
DAA19711      359 SLRVLGFTHEEITSMLRMVSAVLQFGNIVLKRERNTDqasMPDNTAAQKLCRLLGLGVTDFSRALLTPRIKVGRDYVQKA 438  cattle
NP_001258469  355 SLRVLGLLPEEITAMLRTVSAVLQFGNIVLKKERNTDqatMPDNTAAQKLCRLLGLGVTDFSRALLTPRIKVGRDYVQKA 434  house mouse
JAA50065      360 SLRVLGFTHEEITSMLRMVSAVLQFGNIVLKRERNTDqasMPDNTAAQKLCRLLGLGVTDFSRALLTPRIKVGRDYVQKA 439  common vampir...

Feature 1                                                        ######                           
Q6URW6        435 QTKEQADFALEALAKATYERLFRWLVLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINYTNEKLQQLFNHTM 514  house mouse
NP_082297     427 QTKEQADFALEALAKATYERLFRWLVLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINYTNEKLQQLFNHTM 506  house mouse
EDL22740      427 QTKEQADFALEALAKATYERLFRWLVLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINYTNEKLQQLFNHTM 506  house mouse
EDL22741      429 QTKEQADFALEALAKATYERLFRWLVLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINYTNEKLQQLFNHTM 508  house mouse
EDM07465      427 QTKEQADFALEALAKATYERLFRWLVLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINYTNEKLQQLFNHTM 506  Norway rat
NP_001094160  435 QTKEQADFALEALAKATYERLFRWLVLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINYTNEKLQQLFNHTM 514  Norway rat
NP_001139281  439 QTKEQADFALEALAKATYERLFRWLVLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINYTNEKLQQLFNHTM 518  human
DAA19711      439 QTKEQADFALEALAKATYERLFRWLVLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINYTNEKLQQLFNHTM 518  cattle
NP_001258469  435 QTKEQADFALEALAKATYERLFRWLVLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINYTNEKLQQLFNHTM 514  house mouse
JAA50065      440 QTKEQADFALEALAKATYERLFRWLVLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINYTNEKLQQLFNHTM 519  common vampir...

Feature 1                                                                                         
Q6URW6        515 FVLEQEEYQREGIPWTFLDFGLDLQPCIDLIERPANPPGLLALLDEECWFPKATDKSFVEKVAQEQGSHPKFQRPRNLRD 594  house mouse
NP_082297     507 FVLEQEEYQREGIPWTFLDFGLDLQPCIDLIERPANPPGLLALLDEECWFPKATDKSFVEKVAQEQGSHPKFQRPRNLRD 586  house mouse
EDL22740      507 FVLEQEEYQREGIPWTFLDFGLDLQPCIDLIERPANPPGLLALLDEECWFPKATDKSFVEKVAQEQGSHPKFQRPRNLRD 586  house mouse
EDL22741      509 FVLEQEEYQREGIPWTFLDFGLDLQPCIDLIERPANPPGLLALLDEECWFPKATDKSFVEKVAQEQGSHPKFQRPRNLRD 588  house mouse
EDM07465      507 FVLEQEEYQREGIPWTFLDFGLDLQPCIDLIERPANPPGLLALLDEECWFPKATDKSFVEKVAQEQGSHPKFQRPRNLRD 586  Norway rat
NP_001094160  515 FVLEQEEYQREGIPWTFLDFGLDLQPCIDLIERPANPPGLLALLDEECWFPKATDKSFVEKVAQEQGSHPKFQRPRNLRD 594  Norway rat
NP_001139281  519 FVLEQEEYQREGIPWTFLDFGLDLQPCIDLIERPANPPGLLALLDEECWFPKATDKSFVEKVAQEQGGHPKFQRPRHLRD 598  human
DAA19711      519 FVLEQEEYQREGIPWTFLDFGLDLQPCIDLIERPANPPGLLALLDEECWFPKATDKSFVEKVAQEQGGHPKFQRPRHLRD 598  cattle
NP_001258469  515 FVLEQEEYQREGIPWTFLDFGLDLQPCIDLIERPANPPGLLALLDEECWFPKATDKSFVEKVAQEQGSHPKFQRPRNLRD 594  house mouse
JAA50065      520 FVLEQEEYQREGIPWTFLDFGLDLQPCIDLIERPANPPGLLALLDEECWFPKATDKSFVEKVAQEQGGHPKFQRPRHLRD 599  common vampir...

Feature 1                                                                                         
Q6URW6        595 QADFSVLHYAGKVDYKASEWLMKNMDPLNDNVAALLHQSTDRLTAEIWKDVEGIVGLEQVSSLGDGPPGG---------- 664  house mouse
NP_082297     587 QADFSVLHYAGKVDYKASEWLMKNMDPLNDNVAALLHQSTDRLTAEIWKDVEGIVGLEQVSSLGDGPPGG---------- 656  house mouse
EDL22740      587 QADFSVLHYAGKVDYKASEWLMKNMDPLNDNVAALLHQSTDRLTAEIWKDVEGIVGLEQVSSLGDGPPGG---------- 656  house mouse
EDL22741      589 QADFSVLHYAGKVDYKASEWLMKNMDPLNDNVAALLHQSTDRLTAEIWKDVEGIVGLEQVSSLGDGPPGG---------- 658  house mouse
EDM07465      587 QADFSVLHYAGKVDYKANEWLMKNMDPLNDNVAALLHQSTDRLTAEIWKDVEGIVGLEQVSSLGDGPPGG---------- 656  Norway rat
NP_001094160  595 QADFSVLHYAGKVDYKANEWLMKNMDPLNDNVAALLHQSTDRLTAEIWKDVEGIVGLEQVSSLGDGPPGG---------- 664  Norway rat
NP_001139281  599 QADFSVLHYAGKVDYKANEWLMKNMDPLNDNVAALLHQSTDRLTAEIWKDEHGGFQQFSFLGSFPPSPPGsaercssais 678  human
DAA19711      599 QADFSVLHYAGKVDYKANEWLMKNMDPLNDNVATLLHQSTDRLTAEIWKDVEGIVGLEQVSSLGDGPPGG---------- 668  cattle
NP_001258469  595 QADFSVLHYAGKVDYKASEWLMKNMDPLNDNVAALLHQSTDRLTAEIWKDVEGIVGLEQVSSLGDGPPGG---------- 664  house mouse
JAA50065      600 QADFSVLHYAGKVDYKANEWLMKNMDPLNDNVAALLHQSTDRLTAEIWKDVEGIVGLEQVSSLGDGPPGG---------- 669  common vampir...

Feature 1                                                                                         
Q6URW6        665 -----------------------RPRRGMFRTVGQLYKESLSRLMATLSNTNPSFVRCIVPNHEKRAGKLEPRLVLDQLR 721  house mouse
NP_082297     657 -----------------------RPRRGMFRTVGQLYKESLSRLMATLSNTNPSFVRCIVPNHEKRAGKLEPRLVLDQLR 713  house mouse
EDL22740      657 -----------------------RPRRGMFRTVGQLYKESLSRLMATLSNTNPSFVRCIVPNHEKRAGKLEPRLVLDQLR 713  house mouse
EDL22741      659 -----------------------RPRRGMFRTVGQLYKESLSRLMATLSNTNPSFVRCIVPNHEKRAGKLEPRLVLDQLR 715  house mouse
EDM07465      657 -----------------------RPRRGMFRTVGQLYKESLSRLMATLSNTNPSFVRCIVPNHEKRAGKLEPRLVLDQLR 713  Norway rat
NP_001094160  665 -----------------------RPRRGMFRTVGQLYKESLSRLMATLSNTNPSFVRCIVPNHEKRAGKLEPRLVLDQLR 721  Norway rat
NP_001139281  679 ppgvegivgleqvsslgdgppggRPRRGMFRTVGQLYKESLSRLMATLSNTNPSFVRCIVPNHEKRAGKLEPRLVLDQLR 758  human
DAA19711      669 -----------------------RPRRGMFRTVGQLYKESLSRLMATLSNTNPSFVRCIIPNHEKRAGKLDPRLVLDQLR 725  cattle
NP_001258469  665 -----------------------RPRRGMFRTVGQLYKESLSRLMATLSNTNPSFVRCIVPNHEKRAGKLEPRLVLDQLR 721  house mouse
JAA50065      670 -----------------------RPRRGMFRTVGQLYKESLSRLMATLSNTNPSFVRCIVPNHEKRAGKLEPRLVLDQLR 726  common vampir...

Feature 1                                                                                
Q6URW6        722 CNGVLEGIRICRQGFPNRILFQEFRQRYEILTPNAIPKGFMDGKQACEKMIQALELDPNLYRVGQSKIFFR 792  house mouse
NP_082297     714 CNGVLEGIRICRQGFPNRILFQEFRQRYEILTPNAIPKGFMDGKQACEKMIQALELDPNLYRVGQSKIFFR 784  house mouse
EDL22740      714 CNGVLEGIRICRQGFPNRILFQEFRQRYEILTPNAIPKGFMDGKQACEKMIQALELDPNLYRVGQSKIFFR 784  house mouse
EDL22741      716 CNGVLEGIRICRQGFPNRILFQEFRQRYEILTPNAIPKGFMDGKQACEKMIQALELDPNLYRVGQSKIFFR 786  house mouse
EDM07465      714 CNGVLEGIRICRQGFPNRILFQEFRQRYEILTPNAIPKGFMDGKQACEKMIQALELDPNLYRVGQSKIFFR 784  Norway rat
NP_001094160  722 CNGVLEGIRICRQGFPNRILFQEFRQRYEILTPNAIPKGFMDGKQACEKMIQALELDPNLYRVGQSKIFFR 792  Norway rat
NP_001139281  759 CNGVLEGIRICRQGFPNRILFQEFRQRYEILTPNAIPKGFMDGKQACEKMIQALELDPNLYRVGQSKIFFR 829  human
DAA19711      726 CNGVLEGIRICRQGFPNRILFQEFRQRYEILTPNAIPKGFMDGKQACEKMIQALELDPNLYRVGQSKIFFR 796  cattle
NP_001258469  722 CNGVLEGIRICRQGFPNRILFQEFRQRYEILTPNAIPKGFMDGKQACEKMIQALELDPNLYRVGQSKIFFR 792  house mouse
JAA50065      727 CNGVLEGIRICRQGFPNRILFQEFRQRYEILTPNAIPKGFMDGKQACEKMIQALELDPNLYRVGQSKIFFR 797  common vampire bat

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