Conserved Protein Domain Family
MYSc_Myh15_mammals
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cd14929: MYSc_Myh15_mammals 
class II myosin heavy chain 15, motor domain
Myosin motor domain of sarcomeric myosin heavy chain 15 in mammals (also called KIAA1000) . MYH15 is a slow-twitch myosin. Myh15 is a ventricular myosin heavy chain. Myh15 is absent in embryonic and fetal muscles and is found in orbital layer of extraocular muscles at birth. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.
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Statistics
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PSSM-Id: 276892
Aligned: 7 rows
Threshold Bit Score: 1414.35
Created: 8-Jan-2013
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1:ATP binding site [chemical binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                    #########                                           #
Q9Y2K3        117 ASVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRRSEAPPHIFAVANNAFQDMLHNRENQSILFTG 196  human
NP_055796     117 ASVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRRSEAPPHIFAVANNAFQDMLHNRENQSILFTG 196  human
BAA76844      127 ASVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRRSEAPPHIFAVANNAFQDMLHNRENQSILFTG 206  human
NP_001159682   96 ASVLHTLRRRYDHWMIYTYSGIFCVAINPYKWLPVYQKEVMAAYKRKRRSEVPPHIFAVANRAFQDMLRNGENQSIVFTG 175  house mouse
DAA33524       97 ASVLHALRRRYDHWMIYTYSGLSCVSINPHKQLPVYHKAVAAAYKGRRRSDAPPHIFAVANNAFQDMLHSRENQSILFTG 176  cattle
ELR48945      102 ASVLHALRRRYDHWMIYTYSGLSCVSINPHKQLPVYHKAVAAAYKGRRRSDAPPHIFAVANNAFQDMLHSRENQSILFTG 181  Bos grunniens...
ERE76407     1080 PSVLHTLRTRYDHWMIYTYSGLFCVAINPYKWLPVYEKEVMAAYQRKKRSKVPPHIFAVANSALQDMLRSGKNQSILFTG 1159 Chinese hamster

Feature 1         #######                                          ###########                    
Q9Y2K3        197 ESGAGKTVNSKHIIQYFATIAAMIESRKKQGALEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHFGARGMLSSVDI 276  human
NP_055796     197 ESGAGKTVNSKHIIQYFATIAAMIESRKKQGALEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHFGARGMLSSVDI 276  human
BAA76844      207 ESGAGKTVNSKHIIQYFATIAAMIESRKKQGALEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHFGARGMLSSVDI 286  human
NP_001159682  176 ESGSGKTVNTKLIIQYFATMAAISEPKKKLGNLEDQIVKMNPLLEAFGNAKTQKNDNSSRFGKLIRIHFGARGTLSFADI 255  house mouse
DAA33524      177 ESGAGKTVNTKHIIQYFATVATTGESKEKLETLQDQIKQVNPVLEAFGNAKTLRNDNSSRFGKFIRMHFCARGKLSSADI 256  cattle
ELR48945      182 ESGAGKTVNTKHIIQYFATVATTGESKEKLETLQDQIKQVNPVLEAFGNAKTLRNDNSSRFGKFIRMHFCARGKLSSADI 261  Bos grunniens...
ERE76407     1160 ESGAGKTINTKLTIQYFATMAAITEPKKKLGISEDQIVQMNPVLEAFGNAKTLRNDNSSRFGKLIRMHFDARGTLSSADI 1239 Chinese hamster

Feature 1                                                                                         
Q9Y2K3        277 DIYLLEKSRVIFQQaGERNYHIFYQILSGQKELHDLLLVSANPSDFHFCSCGAVTVESLDDAEELLATEQAMDILGFLPD 356  human
NP_055796     277 DIYLLEKSRVIFQQaGERNYHIFYQILSGQKELHDLLLVSANPSDFHFCSCGAVTVESLDDAEELLATEQAMDILGFLPD 356  human
BAA76844      287 DIYLLEKSRVIFQQaGERNYHIFYQILSGQKELHDLLLVSANPSDFHFCSCGAVTVESLDDAEELLATEQAMDILGFLPD 366  human
NP_001159682  256 QIYFLEKSRVVYQQpGERNYHIFYQILSGNQELRNMLLVSTNPSDFHICSCGVVAVESLDDAKEFLATEKAIDVLGFLPD 335  house mouse
DAA33524      257 NIYLLEKSRVIFQQpGERNYHIFYQILSGKKELRDVCLVSENPSDFHFCSHGTVAVESLDDAEELLATDQAMDILGFLPD 336  cattle
ELR48945      262 DIYLLEKSRVIFQQpGERNYHIFYQILSGKKELRDVCLVSENPSDFHFCSHGTVAVESLDDAEELLATDQAMDILGFLPD 341  Bos grunniens...
ERE76407     1240 QIYFLEKSRVVYQQpGERNYHIFYQILSGKQELQDMLLVSTNPSDFHICSCGVVAVESVDDAKEFLATEKAIDILGFLPD 1319 Chinese hamster

Feature 1                                                                                         
Q9Y2K3        357 EKYGCYKLTGAIMHFGNMKFKQKPREEQleaDGTENADKAAFLMGINSSELVKCLIHPRIKVGNEYVTRGQTIEQVTCAV 436  human
NP_055796     357 EKYGCYKLTGAIMHFGNMKFKQKPREEQleaDGTENADKAAFLMGINSSELVKCLIHPRIKVGNEYVTRGQTIEQVTCAV 436  human
BAA76844      367 EKYGCYKLTGAIMHFGNMKFKQKPREEQleaDGTENADKAAFLMGINSSELVKCLIHPRIKVGNEYVTRGQTIEQVTCAV 446  human
NP_001159682  336 EKFGCYKLVGAIMHFGNLKFKRNLREEQleaDGTENADKAAFLMGIHASELLKGLIYPRIKVGNEYVTRSQNLQQVTYAV 415  house mouse
DAA33524      337 EKYGSYKLAGAILHFGNMKFKQKPREEQveaDGTENAGKAAFLMGINSSELVKGLIHPRIKVGNEYVTRSQNVEQVTYAV 416  cattle
ELR48945      342 EKYGSYKLAGAILHFGNMKFKQKPREEQveaDGTENAGKAAFLMGINSSELVKGLIHPRIKVGNEYVTRSQNVEQVTYAV 421  Bos grunniens...
ERE76407     1320 EKFGCYKIIGAIMHIGNLKFRQNPREEQleaDGTENADKAASLMGINSSELVKGLIYPRIKVGNEYVTRSQNIQQVTYAV 1399 Chinese hamster

Feature 1                                             ######                                      
Q9Y2K3        437 GALSKSMYERMFKWLVARINRALDAKLSRQFFIGILDITGFEILEYNSLEQLCINFTNEKLQQFFNWHMFVLEQEEYKKE 516  human
NP_055796     437 GALSKSMYERMFKWLVARINRALDAKLSRQFFIGILDITGFEILEYNSLEQLCINFTNEKLQQFFNWHMFVLEQEEYKKE 516  human
BAA76844      447 GALSKSMYERMFKWLVARINRALDAKLSRQFFIGILDITGFEILEYNSLEQLCINFTNEKLQQFFNWYMFVLEQEEYKKE 526  human
NP_001159682  416 GALSQSIYERMFQWLVARMNQVLDAKLTSHFFVGILDTTGFEILDYNSLEQLCINFTNEKLQQFFNQQLFILEQEEYRKE 495  house mouse
DAA33524      417 GALSKSIYERMFKWLVARINRVLDAKLSRQFFIGILDITGFEMLDYNSLEQLCINFTNEKLQQFFNQHTLVLEQEEYRRE 496  cattle
ELR48945      422 GVLSKSIYERMFKWLVARINRVLDAKLSRQFFIGILDITGFEMLDYNSLEQLCINFTNEKLQQFFNQHTLVLEQEEYRRE 501  Bos grunniens...
ERE76407     1400 GALSKSIYERMFKWLVARMNQVLDTKLSSHFFIALLDITGFEILDYNSLEQLCINLTNEKLQQFFNQHMFILEQEEYRKE 1479 Chinese hamster

Feature 1                                                                                         
Q9Y2K3        517 SIEWVSIGFGLDLQACIDLIEK-PMGILSILEEECMFPKATDLTFKTKLFDNHFGKSVHLQkpkp-dkkkFEAHFELVHY 594  human
NP_055796     517 SIEWVSIGFGLDLQACIDLIEK-PMGILSILEEECMFPKATDLTFKTKLFDNHFGKSVHLQkpkp-dkkkFEAHFELVHY 594  human
BAA76844      527 SIEWVSIGFGLDLQACIDLIEK-PMGILSILEEECMFPKATDLTFKTKLFDNHFGKSVHLQkpkp-dkkkFEAHFELVHY 604  human
NP_001159682  496 GLDWLSIDYGLDVQACIDFIEK-PMGIFSILEEECMLPKATDQMFKTKLFDHHFGKSAYFQtpts-peknFEVHFELAHY 573  house mouse
DAA33524      497 GIDWVSIDFGLDLQACVDLVEKqPMGIFSILEEECMFHQATDVTFNTKLFDNHFGKSVHFQkpkpdnkkkYEADFELVHY 576  cattle
ELR48945      502 GIDWVSIDFGLDLQACVDLVEK-PMGIFSILEEECMFHQATDVTFNTKLFDNHFGKSVHFQkpkpdnkkkYEADFELVHY 580  Bos grunniens...
ERE76407     1480 GLGWIAIDYGLDLQAFIDLIEK-PMGIFSILEEECMFSKATDKTFETKLFDSHFGKSPYFQkpts-aeksYAVHFELAHY 1557 Chinese hamster

Feature 1                                                                                         
Q9Y2K3        595 AGVVPYNISGWLEKNKDLLNETVVAVFQKSsnrllaslfenymstdsaipfGEKKRKKGASFQTVASLHKENLNKLMTNL 674  human
NP_055796     595 AGVVPYNISGWLEKNKDLLNETVVAVFQKSsnrllaslfenymstdsaipfGEKKRKKGASFQTVASLHKENLNKLMTNL 674  human
BAA76844      605 AGVVPYNISGWLEKNKDLLNETVVAVFQKSsnrllaslfenymstdsaipfGEKKRKKGASFQTVASLHKENLNKLMTNL 684  human
NP_001159682  574 AGVVPYNISGWIGKNKGLLNETVVALLQKSsnkvlanlftkdiiagsasqfGEKTHKKGTSFHLITSLHKENINKLMTDL 653  house mouse
DAA33524      577 AGVVPYNISGWLEKNKDFLNETVVAIFQKSsnrllanlfenyistntalqfGEKKRKKGASFQMVASLHKENLNKLMTKL 656  cattle
ELR48945      581 AGVVPYNISGWLEKNKDFLNETVVAIFQKSsnrllanlfenyistntalqfGEKKRKKGASFQMVASLHKENLNKLMTKL 660  Bos grunniens...
ERE76407     1558 AGVVPYNISGWLGKNKDILNETVVAVLQKSsnkvlaslftndiisgsatqfGEKTRRKGTSFQLISSLHKENINKLMTDL 1637 Chinese hamster

Feature 1                                                                                         
Q9Y2K3        675 KSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQRYCILNPRTFPKSKFVSSRKAA 754  human
NP_055796     675 KSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQRYCILNPRTFPKSKFVSSRKAA 754  human
BAA76844      685 KSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQRYCILNPRTFPKSKFVSSRKAA 764  human
NP_001159682  654 KSTAPHFVRCINPNKNKIPGVMDPFLVLQQLRCNGVLEGIRVCCEAFPSWMLYDDFKQRYWILNPRIFSKSKFVSSRKAT 733  house mouse
DAA33524      657 KSTAPHFVRCINPNVNKTPGVMDPYLVLQQLRCNGVLEGITICREGFPHRLLYADFKQRYYILNPRVFPKSKFASNRKAA 736  cattle
ELR48945      661 KSTAPHFVRCINPNVNKTPGVMDPYLVLQQLRCNGVLEGITICREGFPHRLLYADFKQRYYILNPRVFPKSKFASNRKAA 740  Bos grunniens...
ERE76407     1638 KSTAPHFVRCINPNMNKMPGVLDPFLVLQQLRCNGVLEGIRVCCEGFPIRMLYDDFKQRYCILNPRIFSKTEFVSSRKAT 1717 Chinese hamster

Feature 1                                 
Q9Y2K3        755 EELLGSLEIDHTQYRFGITKVFFK 778  human
NP_055796     755 EELLGSLEIDHTQYRFGITKVFFK 778  human
BAA76844      765 EELLGSLEIDHTQYRFGITKVFFK 788  human
NP_001159682  734 EEVLDFLEIDHPHYQCGVTKVFFK 757  house mouse
DAA33524      737 EELLDSLEIDHTQYRFGITKVLLK 760  cattle
ELR48945      741 EELLDSLEIDHTQYRFGITKVLLK 764  Bos grunniens mutus
ERE76407     1718 EGVLGFLEVDNSQYQCGVTKVFLK 1741 Chinese hamster

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