Conserved Protein Domain Family
MYSc_Myh6
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cd14916: MYSc_Myh6 
class II myosin heavy chain 6, motor domain
Myosin motor domain of alpha (or fast) cardiac muscle myosin heavy chain 6. Cardiac muscle myosin is a hexamer consisting of two heavy chain subunits, two light chain subunits, and two regulatory subunits. This gene encodes the alpha heavy chain subunit of cardiac myosin. Mutations in this gene cause familial hypertrophic cardiomyopathy and atrial septal defect. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.
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Statistics
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PSSM-Id: 276880
Aligned: 22 rows
Threshold Bit Score: 1289.63
Created: 8-Jan-2013
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1:ATP binding site [chemical binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                 #########                                           #
P13533      99 PAVLFNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQsILITG 178  human
P02563      98 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQsILITG 177  Norway rat
BAA00791    99 PAVLFNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQsILITG 178  human
CAA79675    99 PAVLFNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQsILITG 178  human
P13539      99 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPAHIFSISDNAYQYMLTDRENQsILITG 178  golden hamster
A59234      92 PAVLYNLKERYASWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRTEVPPHIFSISDNAYQNMLTDRENQsILITG 171  common quail
EAW66155    99 PAVLFNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQsILITG 178  human
NP_002462   99 PAVLFNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQsILITG 178  human
NP_058935   99 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQsILITG 178  Norway rat
EHH27757    99 PAVLFNLKDRYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQsILITG 178  rhesus monkey

Feature 1      #######                                                ###########              
P13533     179 ESGAGKTVNTKRVIQYFASIAAIGDRgKKDNANANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGK 258  human
P02563     178 ESGAGKTVNTKRVIQYFASIAAIGDRsKKDNPNANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGK 257  Norway rat
BAA00791   179 ESGAGKTVNTKRVIQYFASIAAIGDRgKKDNANANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGK 258  human
CAA79675   179 ESGAGKTVNTKRVIQYFASIAAIGDRgKKDNANANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGK 258  human
P13539     179 ESGAGKTVNTKRVIQYFASIAAIGDRsKKDNPNANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGK 258  golden hamster
A59234     172 ESGAGKTVNTKRVIQYFASIAAIGDR-KKEVANSSKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGK 250  common quail
EAW66155   179 ESGAGKTVNTKRVIQYFASIAAIGDRgKKDNANANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGK 258  human
NP_002462  179 ESGAGKTVNTKRVIQYFASIAAIGDRgKKDNANANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGK 258  human
NP_058935  179 ESGAGKTVNTKRVIQYFASIAAIGDRsKKDNPNANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGK 258  Norway rat
EHH27757   179 ESGAGKTVNTKRVIQYFASIAAIGDRgKKDNANANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGK 258  rhesus monkey

Feature 1                                                                                      
P13533     259 LASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTNNPYDYAFVSQGEVSVASIDDSEELMATDSAFD 338  human
P02563     258 LASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTNNPYDYAFVSQGEVSVASIDDSEELLATDSAFD 337  Norway rat
BAA00791   259 LASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTNNPYDYAFVSQGEVSVASIDDSEELMATDSAFD 338  human
CAA79675   259 LASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTNNPYDYAFVSQGEVSVASIDDSEELMATDSAFD 338  human
P13539     259 LASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTNNPYDYAFVSQGEVSVASIDDSEELLATDSAFD 338  golden hamster
A59234     251 LASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLEMLLITNNPYDYSYVSQGEVTVASIDDSEELLATDSAFD 330  common quail
EAW66155   259 LASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTNNPYDYAFVSQGEVSVASIDDSEELMATDSAFD 338  human
NP_002462  259 LASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTNNPYDYAFVSQGEVSVASIDDSEELMATDSAFD 338  human
NP_058935  259 LASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTNNPYDYAFVSQGEVSVASIDDSEELLATDSAFD 338  Norway rat
EHH27757   259 LASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTNNPYDYAFVSQGEVSVASIDDSEELMATDSAFD 338  rhesus monkey

Feature 1                                                                                      
P13533     339 VLGFTSEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQSV 418  human
P02563     338 VLGFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQSV 417  Norway rat
BAA00791   339 VLGFTSEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQSV 418  human
CAA79675   339 VLGFTSEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQSV 418  human
P13539     339 VLGFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQSV 418  golden hamster
A59234     331 VLGFTAEEKAGVYKLTGAIMHFGNMKFKQKQREEQAEPDGTEDADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQSV 410  common quail
EAW66155   339 VLGFTSEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQSV 418  human
NP_002462  339 VLGFTSEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQSV 418  human
NP_058935  339 VLGFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQSV 418  Norway rat
EHH27757   339 VLGFTSEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQSV 418  rhesus monkey

Feature 1                                                 ######                               
P13533     419 QQVYYSIGALAKAVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLE 498  human
P02563     418 QQVYYSIGALAKSVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLE 497  Norway rat
BAA00791   419 QQVYYSIGALAKAVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLE 498  human
CAA79675   419 QQVYYSIGALAKAVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLE 498  human
P13539     419 QQVYYSIGALGKSVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLE 498  golden hamster
A59234     411 QQVYYSIGALAKAVYEKMFNWMVVRINNSLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLE 490  common quail
EAW66155   419 QQVYYSIGALAKAVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLE 498  human
NP_002462  419 QQVYYSIGALAKAVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLE 498  human
NP_058935  419 QQVYYSIGALAKSVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLE 498  Norway rat
EHH27757   419 QQVYYSIGALAKAVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINLPNEKLQQFFNHHMFVLE 498  rhesus monkey

Feature 1                                                                                      
P13533     499 QEEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLYDNHLGKSNNFQKPRNIKGKQEAHF 578  human
P02563     498 QEEYKKEGIEWEFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLYDNHLGKSNNFQKPRNVKGKQEAHF 577  Norway rat
BAA00791   499 QEEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLYDNHLGKSNNFQKPRNIKGKPEAHF 578  human
CAA79675   499 QEEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLYDNHLGKSNNFQKPRNIKGKQEAHF 578  human
P13539     499 QEEYKKEGIEWEFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLYDNHLGKSNNFQKPRNVKGKQEAHF 578  golden hamster
A59234     491 QEEYKKEGIEWEFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKASDMTFKAKLFDNHLGKSANFGKPRNVKGKSEAHF 570  common quail
EAW66155   499 QEEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLYDNHLGKSNNFQKPRNIKGKQEAHF 578  human
NP_002462  499 QEEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLYDNHLGKSNNFQKPRNIKGKQEAHF 578  human
NP_058935  499 QEEYKKEGIEWEFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLYDNHLGKSNNFQKPRNVKGKQEAHF 578  Norway rat
EHH27757   499 QVEYKKEGIEWTFIDFGMDLPACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLYDNHLGKSNNFQKPRNIKGKQEAHF 578  rhesus monkey

Feature 1                                                                                      
P13533     579 SLIHYAGTVDYNILGWLEKNKDPLNETVVALYQKSSLKLMATLFSSYAtadt-gdsGKSKGGKKKGSSFQTVSALHRENL 657  human
P02563     578 SLVHYAGTVDYNILGWLEKNKDPLNETVVGLYQKSSLKLMATLFSTYAsadt-gdsGKGKGGKKKGSSFQTVSALHRENL 656  Norway rat
BAA00791   579 SLIHYAGTVDYNILGWLEKNKDPLNETVVGLYQKSSLKLMATLFSSYAtadt-gdsGKSKGGKKKGSSFQTVSALHRENL 657  human
CAA79675   579 SLIHYAGTVDYNILGWLEKNKDPLNETVVALYQKSSLKLMATLFSSYAtadt-gdsGKSKGGKKKGSSFQTVSALHRENL 657  human
P13539     579 SLVHYAGTVDYNILGWLEKNKDPLNETVVGLYQKSSLKLMATLFSTYAsada-gdsGKGKGGKKKGSSFQTVSALHRENL 657  golden hamster
A59234     571 SLIHYAGTVDYNIIGWLEKNKDPLNETVVGLYQKSALKLLASLFSNYAgadaggdsGKGKGAKKKGSSFQTVSALHRENL 650  common quail
EAW66155   579 SLIHYAGTVDYNILGWLEKNKDPLNETVVALYQKSSLKLMATLFSSYAtadt-gdsGKSKGGKKKGSSFQTVSALHRENL 657  human
NP_002462  579 SLIHYAGTVDYNILGWLEKNKDPLNETVVALYQKSSLKLMATLFSSYAtadt-gdsGKSKGGKKKGSSFQTVSALHRENL 657  human
NP_058935  579 SLVHYAGTVDYNILGWLEKNKDPLNETVVGLYQKSSLKLMATLFSTYAsadt-gdsGKGKGGKKKGSSFQTVSALHRENL 657  Norway rat
EHH27757   579 SLIHYAGTVDYNILGWLEKNKDPLNETVVALYQKSSLKLMATLFSSYAsadi-gesGKSKGGKKKGSSFQTVSALHRENL 657  rhesus monkey

Feature 1                                                                                      
P13533     658 NKLMTNLRTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPVAIPEGQF 737  human
P02563     657 NKLMTNLRTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQF 736  Norway rat
BAA00791   658 NKLMTNLRTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPVAIPEGQF 737  human
CAA79675   658 NKLMTNLRTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPVAIPEGQF 737  human
P13539     658 NKLMTNLRTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQF 737  golden hamster
A59234     651 NKLMANLKTTHPHFVRCLIPNERKEPGVMDNSLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPTAIPEGQF 730  common quail
EAW66155   658 NKLMTNLRTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPVAIPEGQF 737  human
NP_002462  658 NKLMTNLRTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPVAIPEGQF 737  human
NP_058935  658 NKLMTNLRTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQF 737  Norway rat
EHH27757   658 NKLMTNLRTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQF 737  rhesus monkey

Feature 1                                     
P13533     738 IDSRKGTEKLLSSLDIDHNQYKFGHTKVFFK 768  human
P02563     737 IDSGKGAEKLLGSLDIDHNQYKFGHTKVFFK 767  Norway rat
BAA00791   738 IDSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 768  human
CAA79675   738 IDSRKGTEKLLSSLDIDHNQYKFGHTKVFFK 768  human
P13539     738 IDSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 768  golden hamster
A59234     731 IDSRKGAEKLLGSLDIDHNQYKFGHTKVFFK 761  common quail
EAW66155   738 IDSRKGTEKLLSSLDIDHNQYKFGHTKVFFK 768  human
NP_002462  738 IDSRKGTEKLLSSLDIDHNQYKFGHTKVFFK 768  human
NP_058935  738 IDSRKGAEKLLGSLDIDHNQYKFGHTKVFFK 768  Norway rat
EHH27757   738 IDSRKGSEKLLSSLDIDHNQYKFGHTKVFFK 768  rhesus monkey

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