Conserved Protein Domain Family
MYSc_Myh4
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cd14915: MYSc_Myh4 
class II myosin heavy chain 4, motor domain
Myosin motor domain of skeletal muscle myosin heavy chain 4 (also called MYH2B, MyHC-2B, MyHC-IIb). Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.
Links
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Statistics
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PSSM-Id: 276879
Aligned: 16 rows
Threshold Bit Score: 1290.84
Created: 20-Mar-2013
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1:ATP binding site [chemical binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                    #########                                           #
Q5SX39        100 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 179  house mouse
NP_034985     100 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 179  house mouse
BAE23716      100 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 179  house mouse
NP_062198     100 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 179  Norway rat
Q29RW1        100 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 179  Norway rat
NP_001070262  100 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVTAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 179  dog
EAW90004      100 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVTAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 179  human
Q076A5        100 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVTAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 179  dog
Q9Y623        100 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVTAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 179  human
EHB04543      100 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVGAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 179  naked mole-rat

Feature 1         #######                                                 ###########             
Q5SX39        180 ESGAGKTVNTKRVIQYFATIAVTGDKkkeeatsGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGATG 259  house mouse
NP_034985     180 ESGAGKTVNTKRVIQYFATIAVTGDKkkeeatsGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGATG 259  house mouse
BAE23716      180 ESGAGKTVNTKRVIQYFATIAVTGDKkkeeatsGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGATG 259  house mouse
NP_062198     180 ESGAGKTVNTKRVIQYFATIAVTGDKkkeeapsGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGATG 259  Norway rat
Q29RW1        180 ESGAGKTVNTKRVIQYFATIAVTGDKkkeeapsGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGATG 259  Norway rat
NP_001070262  180 ESGAGKTVNTKRVIQYFATIAITGEKkkeestpGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGATG 259  dog
EAW90004      180 ESGAGKTVNTKRVIQYFATIAVTGEKkkeepasGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGATG 259  human
Q076A5        180 ESGAGKTVNTKRVIQYFATIAITGEKkkeestpGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGATG 259  dog
Q9Y623        180 ESGAGKTVNTKRVIQYFATIAVTGEKkkeepasGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGATG 259  human
EHB04543      180 ESGAGKTVNTKRVIQYFATIAVAGEKkkeeapsGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTG 259  naked mole-rat

Feature 1                                                                                         
Q5SX39        260 KLASADIETYLLEKSRVTFQLKAERSYHIFYQIMSNKKPELIEMLLITTNPYDFAYVSQGEITVPSIDDQEELMATDTAV 339  house mouse
NP_034985     260 KLASADIETYLLEKSRVTFQLKAERSYHIFYQIMSNKKPELIEMLLITTNPYDFAYVSQGEITVPSIDDQEELMATDTAV 339  house mouse
BAE23716      260 KLASADIETYLLEKSRVTFQLKAERSYHIFYQIMSNKKPELIEMLLITTNPYDFAYVSQGEITVPSIDDQEELMATDTAV 339  house mouse
NP_062198     260 KLASADIETYLLEKSRVTFQLKAERSYHIFYQVMSNKKPELIEMLLITTNPYDFAYVSQGEITVPSIDDQEELMATDTAV 339  Norway rat
Q29RW1        260 KLASADIETYLLEKSRVTFQLKAERSYHIFYQVMSNKKPELIEMLLITTNPYDFAYVSQGEITVPSIDDQEELMATDTAV 339  Norway rat
NP_001070262  260 KLASADIETYLLEKSRVTFQLKAERSYHIFYQIMSNKKPELIEMLLITTNPYDFAFVSQGEITVPSIDDQEELIATDSAV 339  dog
EAW90004      260 KLASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIEMLLITTNPYDFAFVSQGEITVPSIDDQEELMATDSAV 339  human
Q076A5        260 KLASADIETYLLEKSRVTFQLKAERSYHIFYQIMSNKKPELIEMLLITTNPYDFAFVSQGEITVPSIDDQEELIATDSAV 339  dog
Q9Y623        260 KLASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIEMLLITTNPYDFAFVSQGEITVPSIDDQEELMATDSAV 339  human
EHB04543      260 KLASADIETYLLEKSRVTFQLKAERSYHIFYQIMSNKKPELIEMLLITTNPYDFAYVSQGEITVPSIDDQEELMATDSAV 339  naked mole-rat

Feature 1                                                                                         
Q5SX39        340 DILGfsaDEKVAIYKLTGAVMHYGNMKFKQKQREEqaePDGTEVADKAAYLTSLNSADLLKALCYPRVKVGNEYVTKGQT 419  house mouse
NP_034985     340 DILGfsaDEKVAIYKLTGAVMHYGNMKFKQKQREEqaePDGTEVADKAAYLTSLNSADLLKALCYPRVKVGNEYVTKGQT 419  house mouse
BAE23716      340 DILGfsaDEKVAIYKLTGAVMHYGNMKFKQKQREEqaePDGTEVADKAAYLTSLNSADLLKALCYPRVKVGNEYVTKGQT 419  house mouse
NP_062198     340 DILGftaDEKVAIYKLTGAVMHYGNMKFKQKQREEqaePDGTEVADKAAYLTSLNSADLLKALCYPRVKVGNEYVTKGQT 419  Norway rat
Q29RW1        340 DILGftaDEKVAIYKLTGAVMHYGNMKFKQKQREEqaePDGTEVADKAAYLTSLNSADLLKALCYPRVKVGNEYVTKGQT 419  Norway rat
NP_001070262  340 DILGfspDEKAAIYKLTGAVMHYGNMKFKQKQREEqaePDGTEVADKAAYLQSLNSADLLKALCYPRVKVGNEYVTKGQT 419  dog
EAW90004      340 DILGftaDEKVAIYKLTGAVMHYGNMKFKQKQREEqaePDGTEVADKAAYLTSLNSADLLKSLCYPRVKVGNEFVTKGQT 419  human
Q076A5        340 DILGfspDEKAAIYKLTGAVMHYGNMKFKQKQREEqaePDGTEVADKAAYLQSLNSADLLKALCYPRVKVGNEYVTKGQT 419  dog
Q9Y623        340 DILGftaDEKVAIYKLTGAVMHYGNMKFKQKQREEqaePDGTEVADKAAYLTSLNSADLLKSLCYPRVKVGNEFVTKGQT 419  human
EHB04543      340 DILGfsaDEKAAIYKLTGAVMHYGNMKFKQKQREEqaePDGTEVADKAAYLQSLNSADLLKALCYPRVKVGNEYVTKGQT 419  naked mole-rat

Feature 1                                                     ######                              
Q5SX39        420 VQQVYNSVGALAKSMYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDfNTLEQLCINFTNEKLQQFFNHHMFVL 499  house mouse
NP_034985     420 VQQVYNSVGALAKSMYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDfNTLEQLCINFTNEKLQQFFNHHMFVL 499  house mouse
BAE23716      420 VQQVYNSVGALAKSMYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDfNTLEQLCINFTNEKLQQFFNHHMFVL 499  house mouse
NP_062198     420 VQQVYNSVGALAKAMYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDfNTLEQLCINFTNEKLQQFFNHHMFVL 499  Norway rat
Q29RW1        420 VQQVYNSVGALAKAMYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDfNTLEQLCINFTNEKLQQFFNHHMFVL 499  Norway rat
NP_001070262  420 VQQVYNSVGALAKSIYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDfNSLEQLCINFTNEKLQQFFNHHMFVL 499  dog
EAW90004      420 VQQVYNAVGALAKAIYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDfNSLEQLCINFTNEKLQQFFNHHMFVL 499  human
Q076A5        420 VQQVYNSVGALAKSIYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDfNSLEQLCINFTNEKLQQFFNHHMFVL 499  dog
Q9Y623        420 VQQVYNAVGALAKAIYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDfNSLEQLCINFTNEKLQQFFNHHMFVL 499  human
EHB04543      420 VQQVYNSVGALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDfNTLEQLCINFTNEKLQQFFNHHMFVL 499  naked mole-rat

Feature 1                                                                                         
Q5SX39        500 EQEEYKKEGIDWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSNNFQKPKPAKGKaeaH 579  house mouse
NP_034985     500 EQEEYKKEGIDWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSNNFQKPKPAKGKaeaH 579  house mouse
BAE23716      500 EQEEYKKEGIDWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSNNFQKPKPAKGKaeaH 579  house mouse
NP_062198     500 EQEEYKKEGIEWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSNNFQKPKPAKGKaeaH 579  Norway rat
Q29RW1        500 EQEEYKKEGIEWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSNNFQKPKPAKGKaeaH 579  Norway rat
NP_001070262  500 EQEEYKKEGIEWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSNNFQKPKPAKGKaeaH 579  dog
EAW90004      500 EQEEYKKEGIEWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSNNFQKPKPAKGKpeaH 579  human
Q076A5        500 EQEEYKKEGIEWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSNNFQKPKPAKGKaeaH 579  dog
Q9Y623        500 EQEEYKKEGIEWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSNNFQKPKPAKGKpeaH 579  human
EHB04543      500 EQEEYKKEGIEWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDNSFKNKLYEQHLGKSNNFQKPKPAKGKaeaH 579  naked mole-rat

Feature 1                                                                                         
Q5SX39        580 FSLVHYAGTVDYNIiGWLDKNKDPLNETVVGLYQKSglktlaflfsggqaaeaegGGGKKGGKKKGSSFQTVSALFRENL 659  house mouse
NP_034985     580 FSLVHYAGTVDYNIiGWLDKNKDPLNETVVGLYQKSglktlaflfsggqaaeaegGGGKKGGKKKGSSFQTVSALFRENL 659  house mouse
BAE23716      580 FSLVHYAGTVDYNIiGWLDKNKDPLNETVVGLYQKSglktlaflfsggqaaeaegGGGKKGGKKKGSSFQTVSALFRENL 659  house mouse
NP_062198     580 FSLVHYAGTVDYNIiGWLDKNKDPLNETVVGLYQKSglktlaflfsggqaaeaegGGGKKGGKKKGSSFQTVSALFRENL 659  Norway rat
Q29RW1        580 FSLVHYAGTVDYNIiGWLDKNKDPLNETVVGLYQKSglktlaflfsggqaaeaegGGGKKGGKKKGSSFQTVSALFRENL 659  Norway rat
NP_001070262  580 FSLVHYAGTVDYNIaGWLDKNKDPLNETVVGLYQKSgmktlallfaggqsaeaesGGGKKGGKKKGSSFQTVSALFRENL 659  dog
EAW90004      580 FSLVHYAGTVDYNIaGWLDKNKDPLNETVVGLYQKSamktlaflfsgaqtaeaegGGGKKGGKKKGSSFQTVSALFRENL 659  human
Q076A5        580 FSLVHYAGTVDYNIaGWLDKNKDPLNETVVGLYQKSgmktlallfaggqsaeaesGGGKKGGKKKGSSFQTVSALFRENL 659  dog
Q9Y623        580 FSLVHYAGTVDYNIaGWLDKNKDPLNETVVGLYQKSamktlaflfsgaqtaeaegGGGKKGGKKKGSSFQTVSALFRENL 659  human
EHB04543      580 FSLVHYAGTVDYNIiGWLDKNKDPLNETVVGLYQKSglktlaflfvggqaaeaegGGGKKGGKKKGSSFQTVSALFRENL 659  naked mole-rat

Feature 1                                                                                         
Q5SX39        660 NKLMTNLKSTHPHFVRCLIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLnasaiPEGQF 739  house mouse
NP_034985     660 NKLMTNLKSTHPHFVRCLIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLnasaiPEGQF 739  house mouse
BAE23716      660 NKLMTNLKSTHPHFVRCLIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLnasaiPEGQF 739  house mouse
NP_062198     660 NKLMTNLKSTHPHFVRCLIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLnasaiPEGQF 739  Norway rat
Q29RW1        660 NKLMTNLKSTHPHFVRCLIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLnasaiPEGQF 739  Norway rat
NP_001070262  660 NKLMTNLRSTHPHFVRCLIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLnasaiPEGQF 739  dog
EAW90004      660 NKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLnasaiPEGQF 739  human
Q076A5        660 NKLMTNLRSTHPHFVRCLIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLnasaiPEGQF 739  dog
Q9Y623        660 NKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLnasaiPEGQF 739  human
EHB04543      660 NKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLnasaiPEGQF 739  naked mole-rat

Feature 1                                        
Q5SX39        740 IDSKKASEKLLGSIDIDHTQYKFGHTKVFFK 770  house mouse
NP_034985     740 IDSKKASEKLLGSIDIDHTQYKFGHTKVFFK 770  house mouse
BAE23716      740 IDSKKASEKLLGSIDIDHTQYKFGHTKVFFK 770  house mouse
NP_062198     740 IDSKKASEKLLGSIDIDHTQYKFGHTKVFFK 770  Norway rat
Q29RW1        740 IDSKKASEKLLGSIDIDHTQYKFGHTKVFFK 770  Norway rat
NP_001070262  740 IDSKKASEKLLGSIDIDHTQYKFGHTKVFFK 770  dog
EAW90004      740 IDSKKASEKLLGSIEIDHTQYKFGHTKVFFK 770  human
Q076A5        740 IDSKKASEKLLGSIDIDHTQYKFGHTKVFFK 770  dog
Q9Y623        740 IDSKKASEKLLGSIEIDHTQYKFGHTKVFFK 770  human
EHB04543      740 IDSKKASEKLLGSIDIDHTQYKFGHTKVFFK 770  naked mole-rat

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