Conserved Protein Domain Family
MYSc_Myh3
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cd14913: MYSc_Myh3 
class II myosin heavy chain 3, motor domain
Myosin motor domain of fetal skeletal muscle myosin heavy chain 3 (MYHC-EMB, MYHSE1, HEMHC, SMHCE) in tetrapods including mammals, lizards, and frogs. This gene is a member of the MYH family and encodes a protein with an IQ domain and a myosin head-like domain. Mutations in this gene have been associated with two congenital contracture (arthrogryposis) syndromes, Freeman-Sheldon syndrome and Sheldon-Hall syndrome. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.
Links
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Statistics
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PSSM-Id: 276878
Aligned: 27 rows
Threshold Bit Score: 1404.03
Created: 8-Jan-2013
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1:ATP binding site [chemical binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                            ####  #####                                  
P11055        100 PAVLYNLKDRYTSWMI--------YTYSGLFCVTVNPYK--WLPVYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTD 169  human
P12847        100 PAVLYNLKDRYTSWMI--------YTYSGLFCVTVNPYK--WLPVYTPEVVDGYRGKKRQEAPPHIFSISDNAYQFMLTD 169  Norway rat
NP_036736     100 PAVLYNLKDRYTSWMI--------YTYSGLFCVTVNPYK--WLPVYTPEVVDGYRGKKRQEAPPHIFSISDNAYQFMLTD 169  Norway rat
P13541        100 PAVLYNLKDRYTSWMI--------YTYSGLFCVTVNPYK--WLPVYNPEVVDGYRGKKRQEAPPHIFSISDNAYQFMLTD 169  house mouse
EDM04782      100 PAVLYNLKDRYTSWMI--------YTYSGLFCVTVNPYK--WLPVYNPEVVDGYRGKKRQEAPPHIFSISDNAYQFMLTD 169  Norway rat
NP_001093105  100 PAVLYNLKDRYTSWMI--------YTYSGLFCVTVNPYK--WLPVYNPEVVDGYRGKKRQEAPPHIFSISDNAYQFMLTD 169  house mouse
JAA42964      100 PAVLYNLKDRYTSWMI--------YTYSGLFCVTVNPYK--WLPVYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTD 169  chimpanzee
JAA42969      100 PAVLYNLKDRYTSWMI--------YTYSGLFCVTVNPYK--WLPVYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTD 169  chimpanzee
ELK31861      100 PAVLYNLKDRYTSWMIyvcagrpgATYSGLFCVTVNPYK--WLPVYNAEVVSAYRGKKRQEAPPHIFSISDNAYQFMLTD 177  Myotis davidii
ELW53086      144 PAVLYNLKDRYTAWMI--------YTYSGLFCVTVNLTPyrCLPVYTPEVVDGYRGKKRQEAPPHIFSISDNAYQFMLTD 215  Chinese tree ...

Feature 1                  ########                                               ###########     
P11055        170 RENQSILITGESGAGKTVNTKRVIQYFATIAATGDLAKKKDSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFI 249  human
P12847        170 RENQSILITGESGAGKTVNTKRVIQYFATIAATGDLAKKKDSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFI 249  Norway rat
NP_036736     170 RENQSILITGESGAGKTVNTKRVIQYFATIAATGDLAKKKDSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFI 249  Norway rat
P13541        170 RENQSILITGESGAGKTVNTKRVIQYFATIAATGDLAKKKDSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFI 249  house mouse
EDM04782      170 RENQSILITGESGAGKTVNTKRVIQYFATIAATGDLAKKKDSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFI 249  Norway rat
NP_001093105  170 RENQSILITGESGAGKTVNTKRVIQYFATIAATGDLAKKKDSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFI 249  house mouse
JAA42964      170 RENQSILITGESGAGKTVNTKRVIQYFATIAATGDLAKKKDSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFI 249  chimpanzee
JAA42969      170 RENQSILITGESGAGKTVNTKRVIQYFATIAATGDLAKKKDSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFI 249  chimpanzee
ELK31861      178 RENQSILITGESGAGKTVNTKRVIQYFATIAATGDLAKKKDSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFI 257  Myotis davidii
ELW53086      216 RENQSILITGESGAGKTVNTKRVIQYFATIAATGDLAKKKDSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFI 295  Chinese tree ...

Feature 1                                                                                         
P11055        250 RIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLITTNPYDYPFISQGEILVASIDDAEE 329  human
P12847        250 RIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLITTNPYDYPFISQGEILVASIDDREE 329  Norway rat
NP_036736     250 RIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLITTNPYDYPFISQGEILVASIDDREE 329  Norway rat
P13541        250 RIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLITTNPYDYPFISQGEILVASIDDAEE 329  house mouse
EDM04782      250 RIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLITTNPYDYPFISQGEILVASIDDAEE 329  Norway rat
NP_001093105  250 RIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLITTNPYDYPFISQGEILVASIDDAEE 329  house mouse
JAA42964      250 RIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLITTNPYDYPFISQGEILVASIDDAEE 329  chimpanzee
JAA42969      250 RIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLITTNPYDYPFISQGEILVASIDDAEE 329  chimpanzee
ELK31861      258 RIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLITTNPYDYPFISQGEILVASIDDAEE 337  Myotis davidii
ELW53086      296 RIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLITTNPYDYPFISQGEILVASIDDAEE 375  Chinese tree ...

Feature 1                                                                                         
P11055        330 LLATDSAIDILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGN 409  human
P12847        330 LLATDSAIDILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGN 409  Norway rat
NP_036736     330 LLATDSAIDILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGN 409  Norway rat
P13541        330 LLATDSAIDILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGN 409  house mouse
EDM04782      330 LLATDSAIDILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGN 409  Norway rat
NP_001093105  330 LLATDSAIDILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGN 409  house mouse
JAA42964      330 LLATDSAIDILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGN 409  chimpanzee
JAA42969      330 LLATDSAIDILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGN 409  chimpanzee
ELK31861      338 LLATDSAIDILGFTAEEKSGIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGN 417  Myotis davidii
ELW53086      376 LLATDSAIDILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGN 455  Chinese tree ...

Feature 1                                                             ######                      
P11055        410 EYVTKGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQF 489  human
P12847        410 EYVTKGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQF 489  Norway rat
NP_036736     410 EYVTKGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQF 489  Norway rat
P13541        410 EYVTKGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQF 489  house mouse
EDM04782      410 EYVTKGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQF 489  Norway rat
NP_001093105  410 EYVTKGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQF 489  house mouse
JAA42964      410 EYVTKGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQF 489  chimpanzee
JAA42969      410 EYVTKGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQF 489  chimpanzee
ELK31861      418 EYVTKGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQF 497  Myotis davidii
ELW53086      456 EYVTKGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQF 535  Chinese tree ...

Feature 1                                                                                         
P11055        490 FNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEK-------PMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSN 562  human
P12847        490 FNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEK-------PMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSN 562  Norway rat
NP_036736     490 FNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEK-------PMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSN 562  Norway rat
P13541        490 FNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEK-------PMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSN 562  house mouse
EDM04782      490 FNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEK-------PMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSN 562  Norway rat
NP_001093105  490 FNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEK-------PMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSN 562  house mouse
JAA42964      490 FNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEK-------PMGIFSILEEECMFPKATDMTFKAKLFDNHLGKSA 562  chimpanzee
JAA42969      490 FNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEK-------PMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSN 562  chimpanzee
ELK31861      498 FNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEK-------PMGIFSILEEECMFPKATDTSFKNKLHDQHLGKSS 570  Myotis davidii
ELW53086      536 FNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEKvsysicpPMGIFSILEEECMFPKATDTSFKNKLHDQHLGKSS 615  Chinese tree ...

Feature 1                                                                                         
P11055        563 NFQKPkvvKGRAEAHFSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATFatadadsgKKKVAKKKG 642  human
P12847        563 NFQKPkvvKGKAEAHFSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATFattdadggKKKVAKKKG 642  Norway rat
NP_036736     563 NFQKPkvvKGKAEAHFSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATFattdadggKKKVAKKKG 642  Norway rat
P13541        563 NFQKPkvvKGKAEAHFSLVHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATFattdadggKKKVAKKKG 642  house mouse
EDM04782      563 NFQKPkvvKGKAEAHFSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATFattdadggKKKVAKKKG 642  Norway rat
NP_001093105  563 NFQKPkvvKGKAEAHFSLVHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATFattdadggKKKVAKKKG 642  house mouse
JAA42964      563 NFQKPrniKGKPEAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYagadapieKGKGKAKKG 642  chimpanzee
JAA42969      563 NFQKPkvvKGKAEAHFSLIHYAGTVDYNITGWLDKNKDPLNDTVVGLYQKSAMKTLASLFSTYasaeadssAKKGAKKKG 642  chimpanzee
ELK31861      571 NFQKPkvvKGKAEAHFSLVHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATFattdadsgKKKVAKKKG 650  Myotis davidii
ELW53086      616 NFQKPkvvKGRAEAHFSLVHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATFatadadsgKKKVAKKKG 695  Chinese tree ...

Feature 1                                                                                         
P11055        643 SSFQTVSALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQR 722  human
P12847        643 SSFQTVSALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQR 722  Norway rat
NP_036736     643 SSFQTVSALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQR 722  Norway rat
P13541        643 SSFQTVSALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQR 722  house mouse
EDM04782      643 SSFQTVSALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQR 722  Norway rat
NP_001093105  643 SSFQTVSALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQR 722  house mouse
JAA42964      643 SSFQTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQR 722  chimpanzee
JAA42969      643 SSFQTVSALFRENLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYGDFKQR 722  chimpanzee
ELK31861      651 SSFQTVSALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQR 730  Myotis davidii
ELW53086      696 SSFQTVSALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQR 775  Chinese tree ...

Feature 1                                                      
P11055        723 YRVLNASAIPEGQFIDSKKACEKLLASIDIDHTQYKFGHTKVFFK 767  human
P12847        723 YRVLNASAIPEGQFIDSKKACEKLLASIDIDHTQYKFGHTKVFFK 767  Norway rat
NP_036736     723 YRVLNASAIPEGQFIDSKKACEKLLASIDIDHTQYKFGHTKVFFK 767  Norway rat
P13541        723 YRVLNASAIPEGQFIDSKKACEKLLASIDIDHTQYKFGHTKVFFK 767  house mouse
EDM04782      723 YRVLNASAIPEGQFIDSKKACEKLLASIDIDHTQYKFGHTKVFFK 767  Norway rat
NP_001093105  723 YRVLNASAIPEGQFIDSKKACEKLLASIDIDHTQYKFGHTKVFFK 767  house mouse
JAA42964      723 YRILNPAAIPEGQFIDSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 767  chimpanzee
JAA42969      723 YKVLNASAIPEGQFIDSKKASEKLLASIDIDHTQYKFGHTKVFFK 767  chimpanzee
ELK31861      731 YRVLNASAIPEGQFIDSKKACEKLLASIDIDHTQYKFGHTKVFFK 775  Myotis davidii
ELW53086      776 YRVLNASAIPEGQFIDSKKACEKLLASIDIDHTQYKFGHTKVFFK 820  Chinese tree shrew

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