Conserved Protein Domain Family
MYSc_Myh2_mammals
?
cd14912: MYSc_Myh2_mammals 
class II myosin heavy chain 2, motor domain
Myosin motor domain of type IIa skeletal muscle myosin heavy chain 2 (also called MYH2A, MYHSA2, MyHC-IIa, MYHas8, MyHC-2A) in mammals. Mutations in this gene results in inclusion body myopathy-3 and familial congenital myopathy. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.
Links
?
Statistics
?
PSSM-Id: 276877
Aligned: 18 rows
Threshold Bit Score: 1293.93
Created: 18-Mar-2013
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
Download Cn3D
  next features
Feature 1:ATP binding site [chemical binding site]
Evidence:
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                                    #########                                           #
Q9UKX2        100 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYKPEVVTAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 179  human
AAH08538      100 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 179  house mouse
NP_999301     100 PGVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVTAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 179  pig
Q9BE41        100 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVTAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 179  cattle
Q9TV63        100 PGVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVTAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 179  pig
NP_001070263  100 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVTAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 179  dog
Q076A7        100 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVTAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 179  dog
NP_001075229  100 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVTAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 179  horse
NP_001034634  100 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 179  house mouse
NP_001159699  100 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVTAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 179  cattle

Feature 1         #######                                                 ###########             
Q9UKX2        180 ESGAGKTVNTKRVIQYFATIAVTGEKKKEEitsgkiqGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTG 259  human
AAH08538      180 ESGAGKTVNTKRVIQYFATIAVTGDKKKEEatsgkmqGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTG 259  house mouse
NP_999301     180 ESGAGKTVNTKRVIQYFATIAVTGEKKKEEptsgkmqGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTG 259  pig
Q9BE41        180 ESGAGKTVNTKRVIQYFATIAVTGDKKKEEitsgkiqGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTG 259  cattle
Q9TV63        180 ESGAGKTVNTKRVIQYFATIAVTGEKKKEEptsgkmqGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTG 259  pig
NP_001070263  180 ESGAGKTVNTKRVIQYFATIAVTGEKKKEEatsgkmqGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTG 259  dog
Q076A7        180 ESGAGKTVNTKRVIQYFATIAVTGEKKKEEatsgkmqGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTG 259  dog
NP_001075229  180 ESGAGKTVNTKRVIQYFATIAVTGEKKKEEpgk--mqGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTG 257  horse
NP_001034634  180 ESGAGKTVNTKRVIQYFATIAVTGDKKKEEatsgkmqGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTG 259  house mouse
NP_001159699  180 ESGAGKTVNTKRVIQYFATIAVTGEKKKEEitsgkiqGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTG 259  cattle

Feature 1                                                                                         
Q9UKX2        260 KLASADIETYLLEKSRVvFQLKAERSYHIFYQITSNKKPELIEMLLITTNPYDYPFVSQGEISVaSIDDQEELMATDSAI 339  human
AAH08538      260 KLASADIETYLLEKSRVtFQLKAERSYHIFYQITSNKKPELIEMLLITTNPYDYPFVSQGEISVaSIDDQEELMATDSAI 339  house mouse
NP_999301     260 KLASADIETYLLEKSRVtFQLKAERSYHIFYQITSNRKPELIEMLLITTNPYDYPFISQGEISVaSIDDQEELIATDSAI 339  pig
Q9BE41        260 KLASADIETYLLEKSRVtFQLKAERSYHIFYQITSNRKPELIEMLLITTNPYDYPFISQGEISVaSIDDQEELIATDSAI 339  cattle
Q9TV63        260 KLASADIETYLLEKSRVtFQLKAERSYHIFYQITSNRKPELIEMLLITTNPYDYPFISQGEISVaSIDDQEELIATDSAI 339  pig
NP_001070263  260 KLASADIETYLLEKSRVtFQLKAERSYHIFYQITSNKKPELIEMLLITTNPYDYPFVSQGEISVaSIDDQEELIATDSAI 339  dog
Q076A7        260 KLASADIETYLLEKSRVtFQLKAERSYHIFYQITSNKKPELIEMLLITTNPYDYPFVSQGEISVaSIDDQEELIATDSAI 339  dog
NP_001075229  258 KLASADIETYLLEKSRVtFQLKAERSYHIFYQITSNRKPELIEMLLITTNPYDYPYVSQGEISVaSIDDQEELIATDSAI 337  horse
NP_001034634  260 KLASADIETYLLEKSRVtFQLKAERSYHIFYQITSNKKPELIEMLLITTNPYDYPFVSQGEISVaSIDDQEELMATDSAI 339  house mouse
NP_001159699  260 KLASADIETYLLEKSRVtFQLKAERSYHIFYQITSNRKPELIEMLLITTNPYDYPFISQGEISVaSIDDQEELIATDSAI 339  cattle

Feature 1                                                                                         
Q9UKX2        340 DILGFTNEEKVSIYKLTGAVMHYGNLKFKQKQREeqaEPDGTEVADKAAYLQSLNSADLLKALCYPRVKVGNEYVTKGQT 419  human
AAH08538      340 DILGFTNDEKVSIYKLTGAVMHYGNMKFKQKQREeqaEPDGTEVADKAAYLQGLNSADLLKALCYPRVKVGNEYVTKGQT 419  house mouse
NP_999301     340 DILGFTNEEKVSIYKLTGAVMHYGNLKFKQKQREeqaEPDGTEVADKAAYLQSLNSADLLKALCYPRVKVGNEYVTKGQT 419  pig
Q9BE41        340 DILGFTNEEKVSIYKLTGAVMHYGNLKFKQKQREeqaEPDGTEVADKAAYLQSLNSADLLKALCYPRVKVGNEYVTKGQT 419  cattle
Q9TV63        340 DILGFTNEEKVSIYKLTGAVMHYGNLKFKQKQREeqaEPDGTEVADKAAYLQSLNSADLLKALCYPRVKVGNEYVTKGQT 419  pig
NP_001070263  340 DILGFTNEEKVSIYKLTGAVMHYGNLKFKQKQREeqaEPDGTEVADKAAYLQSLNSADLLKALCYPRVKVGNEFVTKGQT 419  dog
Q076A7        340 DILGFTNEEKVSIYKLTGAVMHYGNLKFKQKQREeqaEPDGTEVADKAAYLQSLNSADLLKALCYPRVKVGNEFVTKGQT 419  dog
NP_001075229  338 DILGFTNDEKVSIYKLTGAVMHYGNLKFKQKQREeqaEPDGTEVADKAAYLQGLNSADLLKALCYPRVKVGNEFVTKGQT 417  horse
NP_001034634  340 DILGFTNDEKVSIYKLTGAVMHYGNMKFKQKQREeqaEPDGTEVADKAAYLQGLNSADLLKALCYPRVKVGNEYVTKGQT 419  house mouse
NP_001159699  340 DILGFTNEEKVSIYKLTGAVMHYGNLKFKQKQREeqaEPDGTEVADKAAYLQSLNSADLLKALCYPRVKVGNEYVTKGQT 419  cattle

Feature 1                                                     ######                              
Q9UKX2        420 VEQVSNAVGALAKAVYEKMFLWMVARINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVL 499  human
AAH08538      420 VEQVTNAVGALAKAMYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVL 499  house mouse
NP_999301     420 VEQVTNAVGALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVL 499  pig
Q9BE41        420 VEQVTNAVGALAKAVYEKMFLWMVARINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVL 499  cattle
Q9TV63        420 VEQVTNAVGALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVL 499  pig
NP_001070263  420 VEQVTNAVGALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVL 499  dog
Q076A7        420 VEQVTNAVGALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVL 499  dog
NP_001075229  418 VEQVTNAVGALAKAVYDKMFLWMVARINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVL 497  horse
NP_001034634  420 VEQVTNAVGALAKAMYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVL 499  house mouse
NP_001159699  420 VEQVTNAVGALAKAVYEKMFLWMVARINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVL 499  cattle

Feature 1                                                                                         
Q9UKX2        500 EQEEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSANfqkpkvvkgkaeaH 579  human
AAH08538      500 EQEEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSANfqkpkvvkgkaeaH 579  house mouse
NP_999301     500 EQEEYKREGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSANfqkpkpakgkveaH 579  pig
Q9BE41        500 EQEEYKREGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDMSFKNKLYDQHLGKSANfqkpkvvkgkpeaH 579  cattle
Q9TV63        500 EQEEYKREGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSANfqkpkpakgkveaH 579  pig
NP_001070263  500 EQEEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSANfqkpkvvkgkaeaH 579  dog
Q076A7        500 EQEEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSANfqkpkvvkgkaeaH 579  dog
NP_001075229  498 EQEEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSSNfqkpkvvkgkaeaH 577  horse
NP_001034634  500 EQEEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSANfqkpkvvkgkaeaH 579  house mouse
NP_001159699  500 EQEEYKREGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDMSFKNKLYDQHLGKSANfqkpkvvkgkpeaH 579  cattle

Feature 1                                                                                         
Q9UKX2        580 FALIHYAGVVDYNITGWLEKNKDPLNETVVGLYQKSamktlaqlfsgaq-taegegagggakKGGKKKGSSFQTVSALFR 658  human
AAH08538      580 FSLIHYAGTVDYNITGWLDKNKDPLNETVVGLYQKSsvktlaylfsgaqtaeaeassggaakKGAKKKGSSFQTVSALFR 659  house mouse
NP_999301     580 FSLIHYAGTVDYNITGWLDKNKDPLNDTVVGLYQKSalktlaflfsga---qtgeaeaggtkKGGKKKGSSFQTVSALFR 656  pig
Q9BE41        580 FALIHYAGVVDYNITGWLEKNKDPLNDTVVGLYQKSalktlaflfsgt--ptgdseasggtkKGGKKKGSSFQTVSALFR 657  cattle
Q9TV63        580 FSLIHYAGTVDYNITGWLDKNKDPLNDTVVGLYQKSalktlaflfsga---qtgeaeaggtkKGGKKKGSSFQTVSALFR 656  pig
NP_001070263  580 FSLIHYAGVVDYNITGWLDKNKDPLNETVVGLYQKSsmktlaylfsga--qtaeaeasggakKGGKKKGSSFQTVSALFR 657  dog
Q076A7        580 FSLIHYAGVVDYNITGWLDKNKDPLNETVVGLYQKSsmktlaylfsga--qtaeaeasggakKGGKKKGSSFQTVSALFR 657  dog
NP_001075229  578 FSLIHYAGVVDYNITGWLDKNKDPLNETVVGLYQKSsvktlallfsga---qtadaeaggvkKGGKKKGSSFQTVSALFR 654  horse
NP_001034634  580 FSLIHYAGTVDYNITGWLDKNKDPLNETVVGLYQKSsvktlaylfsgaqtaeaeassggaakKGAKKKGSSFQTVSALFR 659  house mouse
NP_001159699  580 FALIHYAGVVDYNITGWLEKNKDPLNDTVVGLYQKSalktlaflfsgt--ptgdseasggtkKGGKKKGSSFQTVSALFR 657  cattle

Feature 1                                                                                         
Q9UKX2        659 ENLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPE 738  human
AAH08538      660 ENLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPE 739  house mouse
NP_999301     657 ENLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPE 736  pig
Q9BE41        658 ENLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPE 737  cattle
Q9TV63        657 ENLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPE 736  pig
NP_001070263  658 ENLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPE 737  dog
Q076A7        658 ENLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPE 737  dog
NP_001075229  655 ENLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPE 734  horse
NP_001034634  660 ENLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPE 739  house mouse
NP_001159699  658 ENLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPE 737  cattle

Feature 1                                           
Q9UKX2        739 GQFIDSKKASEKLLASIDIDHTQYKFGHTKVFFK 772  human
AAH08538      740 GQYIDSKKASEKLLGSIDIDHTQYKFGHTKVFFK 773  house mouse
NP_999301     737 GQYIDSKKASEKLLASIDIDHTQYKFGHTKVFFK 770  pig
Q9BE41        738 GQYIDSKKASEKLLASIDIDHTQYKFGHTKVFFK 771  cattle
Q9TV63        737 GQYIDSKKASEKLLASIDIDHTQYKFGHTKVFFK 770  pig
NP_001070263  738 GQFIDSKKASEKLLASIDIDHTQYKFGHTKVFFK 771  dog
Q076A7        738 GQFIDSKKASEKLLASIDIDHTQYKFGHTKVFFK 771  dog
NP_001075229  735 GQFIDSKKASEKLLASIDIDHTQYKFGHTKVFFK 768  horse
NP_001034634  740 GQYIDSKKASEKLLGSIDIDHTQYKFGHTKVFFK 773  house mouse
NP_001159699  738 GQYIDSKKASEKLLASIDIDHTQYKFGHTKVFFK 771  cattle

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap