Conserved Protein Domain Family
MYSc_Myh1_mammals
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cd14910: MYSc_Myh1_mammals 
class II myosin heavy chain 1, motor domain
Myosin motor domain of type IIx skeletal muscle myosin heavy chain 1 (also called MYHSA1, MYHa, MyHC-2X/D, MGC133384) in mammals. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.
Links
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Statistics
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PSSM-Id: 276875
Aligned: 24 rows
Threshold Bit Score: 1291.61
Created: 18-Mar-2013
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1:ATP binding site [chemical binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                    #########                                           #
Q076A6        100 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVTAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 179  dog
Q28641        100 PAVLYNLKEXYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVTAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 179  rabbit
BAC30831      100 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 179  house mouse
Q5SX40        100 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 179  house mouse
NP_109604     100 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 179  house mouse
NP_001103286  100 PAVLYNLKEXYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVTAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 179  rabbit
NP_001107189  100 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVTAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 179  dog
NP_001116613  100 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVTAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 179  pig
AAI50740      100 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 179  house mouse
NP_001182222  100 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVTAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 179  rhesus monkey

Feature 1         #######                                                 ###########             
Q076A6        180 ESGAGKTVNTKRVIQYFATIAVTGDKKKEEvtsGKIQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTG 259  dog
Q28641        180 ESGAGKTVNTKRVIQYFATIAVTGDKKKEEatsGKMQGTLEDQIISANPLLEAFANAKTVRNDNSSRFGKFIRIHFGTTG 259  rabbit
BAC30831      180 ESGAGKTVNTKRVIQYFATIAVTGEKKKEEatsGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTG 259  house mouse
Q5SX40        180 ESGAGKTVNTKRVIQYFATIAVTGEKKKEEatsGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTG 259  house mouse
NP_109604     180 ESGAGKTVNTKRVIQYFATIAVTGEKKKEEatsGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTG 259  house mouse
NP_001103286  180 ESGAGKTVNTKRVIQYFATIAVTGDKKKEEatsGKMQGTLEDQIISANPLLEAFANAKTVRNDNSSRFGKFIRIHFGTTG 259  rabbit
NP_001107189  180 ESGAGKTVNTKRVIQYFATIAVTGDKKKEEvtsGKIQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTG 259  dog
NP_001116613  180 ESGAGKTVNTKRVIQYFATIAVTGEKKKEEptpGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTG 259  pig
AAI50740      180 ESGAGKTVNTKRVIQYFATIAVTGEKKKEEapsGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTG 259  house mouse
NP_001182222  180 ESGAGKTVNTKRVIQYFATIAVTGEKKKEEvtsGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTG 259  rhesus monkey

Feature 1                                                                                         
Q076A6        260 KLASADIETYLLEKSRVTFQLKAERSYHIFYQIMSNKKPDLIEMLLITTNPYDYAFVSQGEiTVPSIDDQEELIATDSAI 339  dog
Q28641        260 KLASADIETYLLEKSRVTFQLKAERSYHIFYQIMSNKKPDLIEMLLITTNPYDYAFVSQGEiTVPSIDDQEELMATDSAI 339  rabbit
BAC30831      260 KLASADIETYLLEKSRVTFQLKAERSYHIFYQIMSNKKPDLIEMLLITTNPYDYAFVSQGEiTVPSIDDQEELMATDSAI 339  house mouse
Q5SX40        260 KLASADIETYLLEKSRVTFQLKAERSYHIFYQIMSNKKPDLIEMLLITTNPYDYAFVSQGEiTVPSIDDQEELMATDSAI 339  house mouse
NP_109604     260 KLASADIETYLLEKSRVTFQLKAERSYHIFYQIMSNKKPDLIEMLLITTNPYDYAFVSQGEiTVPSIDDQEELMATDSAI 339  house mouse
NP_001103286  260 KLASADIETYLLEKSRVTFQLKAERSYHIFYQIMSNKKPDLIEMLLITTNPYDYAFVSQGEiTVPSIDDQEELMATDSAI 339  rabbit
NP_001107189  260 KLASADIETYLLEKSRVTFQLKAERSYHIFYQIMSNKKPDLIEMLLITTNPYDYAFVSQGEiTVPSIDDQEELIATDSAI 339  dog
NP_001116613  260 KLASADIETYLLEKSRVTFQLKAERSYHIFYQIMSNKKPELIEMLLITTNPYDYAFVSQGEiTVPSIDDQEELMATDSAI 339  pig
AAI50740      260 KLASADIETYLLEKSRVTFQLKAERSYHIFYQIMSNKKPDLIEMLLITTNPYDYAFVSQGEiTVPSIDDQEELMATDSAI 339  house mouse
NP_001182222  260 KLASADIETYLLEKSRVTFQLKAERSYHIFYQIMSNKKPDLIEMLLITTNPYDYAFVSQGEiTVPSIDDQEELMATDSAI 339  rhesus monkey

Feature 1                                                                                         
Q076A6        340 DILGFTSDERVSIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAAYLQSLNSADLLKALCYPRVKVGNEFV----- 414  dog
Q28641        340 DILGFTSDERVSIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAAYLQSLNSXDLLKALCYPRVKVGNEYV----- 414  rabbit
BAC30831      340 DILGFTSDERVSIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKATYLQNLNSADLLKALCYPRVKVGNEYV----- 414  house mouse
Q5SX40        340 DILGFTSDERVSIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAAYLQNLNSADLLKALCYPRVKVGNEYV----- 414  house mouse
NP_109604     340 DILGFTSDERVSIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAAYLQNLNSADLLKALCYPRVKVGNEYV----- 414  house mouse
NP_001103286  340 DILGFTSDERVSIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAAYLQSLNSXDLLKALCYPRVKVGNEYV----- 414  rabbit
NP_001107189  340 DILGFTSDERVSIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAAYLQSLNSADLLKALCYPRVKVGNEFVtkgqt 419  dog
NP_001116613  340 EILGFTSDERVSIYKLTGAVMHYGNLKFKQKQREEQAEPDGTEVADKAAYLQGLNSADLLKALCYPRVKVGNEFV----- 414  pig
AAI50740      340 DILGFTSDERVSIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAAYLQNLNSADLLKALCYPRVKVGNEYV----- 414  house mouse
NP_001182222  340 EILGFTSDERVSIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAAYLQNLNSADLLKALCYPRVKVGNEFV----- 414  rhesus monkey

Feature 1                                                                   ######                
Q076A6        415 ---------TKGQTVQQVYNAVGALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTN 485  dog
Q28641        415 ---------TKGQTVQQVYNAVGALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTN 485  rabbit
BAC30831      415 ---------TKGQTVQQVYNSVGALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTN 485  house mouse
Q5SX40        415 ---------TKGQTVQQVYNSVGALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTN 485  house mouse
NP_109604     415 ---------TKGQTVQQVYNSVGALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTN 485  house mouse
NP_001103286  415 ---------TKGQTVQQVYNAVGALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTN 485  rabbit
NP_001107189  420 vqqhvfntsTITTLSMKVYNAVGALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTN 499  dog
NP_001116613  415 ---------TKGQTVQQVYNAVGALAKAVYDKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTN 485  pig
AAI50740      415 ---------TKGQTVQQVYNSVGALAKAVYEKMFLWMVTRINQHLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTN 485  house mouse
NP_001182222  415 ---------TKGQTVQQVYNAVGALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTN 485  rhesus monkey

Feature 1                                                                                         
Q076A6        486 EKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSNN 565  dog
Q28641        486 EKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSNN 565  rabbit
BAC30831      486 EKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSNN 565  house mouse
Q5SX40        486 EKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSNN 565  house mouse
NP_109604     486 EKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSNN 565  house mouse
NP_001103286  486 EKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSNN 565  rabbit
NP_001107189  500 EKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSNN 579  dog
NP_001116613  486 EKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSNN 565  pig
AAI50740      486 EKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSNN 565  house mouse
NP_001182222  486 EKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSNN 565  rhesus monkey

Feature 1                                                                                         
Q076A6        566 fqkpkpakgkveaHFSLIHYAGTVDYNIGGWLDKNKDPLNETVVGLYQKSAMKTLANLFSGataa---eaeaGGGKKGGK 642  dog
Q28641        566 fqkpkpakrkveaHFSLVHYAGTVDYNITGWLDKNKDPLNETVVGLYQKSAMKTLAFLFTGtaaa----eaeGGGKKGGK 641  rabbit
BAC30831      566 fqkpkpakgkveaHFSLVHYAGTVDYNIAGWLDKNKDPLNETVVGLYQKSSMKTLAYLFSGaaaaaeaesggGGGKKGAK 645  house mouse
Q5SX40        566 fqkpkpakgkveaHFSLVHYAGTVDYNIAGWLDKNKDPLNETVVGLYQKSSMKTLAYLFSGaaaaaeaesggGGGKKGAK 645  house mouse
NP_109604     566 fqkpkpakgkveaHFSLVHYAGTVDYNIAGWLDKNKDPLNETVVGLYQKSSMKTLAYLFSGaaaaaeaesggGGGKKGAK 645  house mouse
NP_001103286  566 fqkpkpakrkveaHFSLVHYAGTVDYNITGWLDKNKDPLNETVVGLYQKSAMKTLAFLFTGtaaa----eaeGGGKKGGK 641  rabbit
NP_001107189  580 fqkpkpakgkveaHFSLIHYAGTVDYNIGGWLDKNKDPLNETVVGLYQKSAMKTLANLFSGataa---eaeaGGGKKGGK 656  dog
NP_001116613  566 fqkpkpakgkaeaHFSLIHYAGTVDYNITGWLDKNKDPLNETVVGLYQKSSVKTLAFLFAErqs-----seeGGTKKGGK 640  pig
AAI50740      566 fqkpkpakgkveaHFSLVHYAGTVDYNIAGWLDKNKDPLNETVVGLYQKSSMKTLAYLFSGaaaaaeaesggGGGKKGAK 645  house mouse
NP_001182222  566 fqkpkpakgkpeaHFSLIHYAGTVDYNIAGWLDKNKDPLNETVVGLYQKSAMKTLALLFTGataa----eaeAGGKKGGK 641  rhesus monkey

Feature 1                                                                                         
Q076A6        643 KKGSSFQTVSALFRENLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADF 722  dog
Q28641        642 KKGSSFQTVSALFRENLNKLMTNLRTHSPHFVRSIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADF 721  rabbit
BAC30831      646 KKGSSFQTVSALFRENLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADF 725  house mouse
Q5SX40        646 KKGSSFQTVSALFRENLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADF 725  house mouse
NP_109604     646 KKGSSFQTVSALFRENLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADF 725  house mouse
NP_001103286  642 KKGSSFQTVSALFRENLNKLMTNLRTHSPHFVRSIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADF 721  rabbit
NP_001107189  657 KKGSSFQTVSALFRENLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADF 736  dog
NP_001116613  641 KKGSSFQTVSALFRENLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADF 720  pig
AAI50740      646 KKGSSFQTVSALFRENLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADF 725  house mouse
NP_001182222  642 KKGSSFQTVSALFRENLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADF 721  rhesus monkey

Feature 1                                                         
Q076A6        723 KQRYKVLnasaiPEGQFIDSKKASEKLLGSIDVDHTQYKFGHTKVFFK 770  dog
Q28641        722 KQRYKVLnasaiPEGQFIDSKKASEKLLGSIDVDHTQYKFGHTKVFFK 769  rabbit
BAC30831      726 KQRYKVLnasaiPEGQFIDSKKASEKLLGSIDIDHTQYKFGHTKVFFK 773  house mouse
Q5SX40        726 KQRYKVLnasaiPEGQFIDSKKASEKLLGSIDIDHTQYKFGHTKVFFK 773  house mouse
NP_109604     726 KQRYKVLnasaiPEGQFIDSKKASEKLLGSIDIDHTQYKFGHTKVFFK 773  house mouse
NP_001103286  722 KQRYKVLnasaiPEGQFIDSKKASEKLLGSIDVDHTQYKFGHTKVFFK 769  rabbit
NP_001107189  737 KQRYKVLnasaiPEGQFIDSKKASEKLLGSIDVDHTQYKFGHTKVFFK 784  dog
NP_001116613  721 KQRYKVLnasaiPEGQFIDSKKASEKLLGSIDIDHTQYKFGHTKVFFK 768  pig
AAI50740      726 KQRYKVLnasaiPEGQFIDSKKASEKLLGSIDIDHTQYKFGHTKVFFK 773  house mouse
NP_001182222  722 KQRYKVLnasaiPEGQFIDSKKASEKLLGSIDVDHTQYKFGHTKVFFK 769  rhesus monkey

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