Conserved Protein Domain Family
MYSc_Myo44
?
cd14905: MYSc_Myo44 
class XLIV myosin, motor domain
There is little known about the function of the myosin XLIV class. Members here include cellular slime mold Polysphondylium and soil-living amoeba Dictyostelium. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.
Links
?
Statistics
?
PSSM-Id: 276870
Aligned: 3 rows
Threshold Bit Score: 1347.06
Created: 7-Jan-2013
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
Download Cn3D
  next features
Feature 1:ATP binding site [chemical binding site]
Evidence:
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                                           ####### ##                                         ##
Q86AC8               453 DTLINIIQARYKKEIIYTYIGPILVSVNPLRYLPfLHSQELVRNYNQRRGLPPHLFALAAKAISDMQDFRRDQLIFIGGE 532  Dictyo...
WGS:AAFI:DDB0232322  453 DTLINIIQARYKKEIIYTYIGPILVSVNPLRYLPfLHSQELVRNYNQRRGLPPHLFALAAKAISDMQDFRRDQLIFIGGE 532  Dictyo...
XP_643200            453 DTLINIIQARYKKEIIYTYIGPILVSVNPLRYLPfLHSQELVRNYNQRRGLPPHLFALAAKAISDMQDFRRDQLIFIGGE 532  Dictyo...

Feature 1                ######                                     ###########                          
Q86AC8               533 SGSGKSENTKIIIQYLLTTdLSRSKYLRDYILESGIILESFGHASTDSNHNSSRWGKYFEMFYSLYGEIQGAKLYSYFLD 612  Dictyo...
WGS:AAFI:DDB0232322  533 SGSGKSENTKIIIQYLLTTdLSRSKYLRDYILESGIILESFGHASTDSNHNSSRWGKYFEMFYSLYGEIQGAKLYSYFLD 612  Dictyo...
XP_643200            533 SGSGKSENTKIIIQYLLTTdLSRSKYLRDYILESGIILESFGHASTDSNHNSSRWGKYFEMFYSLYGEIQGAKLYSYFLD 612  Dictyo...

Feature 1                                                                                                
Q86AC8               613 ENRVTYQNKGERNFHIFYQFLKGITDEEKAAYQLGDINSYHYLNQGGSIsvESIDDNRVFDRLKMSFVFFDFPSEKIDLI 692  Dictyo...
WGS:AAFI:DDB0232322  613 ENRVTYQNKGERNFHIFYQFLKGITDEEKAAYQLGDINSYHYLNQGGSIsvESIDDNRVFDRLKMSFVFFDFPSEKIDLI 692  Dictyo...
XP_643200            613 ENRVTYQNKGERNFHIFYQFLKGITDEEKAAYQLGDINSYHYLNQGGSIsvESIDDNRVFDRLKMSFVFFDFPSEKIDLI 692  Dictyo...

Feature 1                                                                                                
Q86AC8               693 FKTLSFIIILGNVTFFQKNGKTEVKDRTLIESLSHNITFDSTKLENILISDRSMPVNEAVENRDSLARSLYSALFHWIID 772  Dictyo...
WGS:AAFI:DDB0232322  693 FKTLSFIIILGNVTFFQKNGKTEVKDRTLIESLSHNITFDSTKLENILISDRSMPVNEAVENRDSLARSLYSALFHWIID 772  Dictyo...
XP_643200            693 FKTLSFIIILGNVTFFQKNGKTEVKDRTLIESLSHNITFDSTKLENILISDRSMPVNEAVENRDSLARSLYSALFHWIID 772  Dictyo...

Feature 1                                  ######                                                        
Q86AC8               773 FLNSKLKPTQYSHTLGILDLFGQESSQLNGYEQFSINFLEERLQQIYLQTVLKQEQREYQTERIPWMTPIsfKDNEESVE 852  Dictyo...
WGS:AAFI:DDB0232322  773 FLNSKLKPTQYSHTLGILDLFGQESSQLNGYEQFSINFLEERLQQIYLQTVLKQEQREYQTERIPWMTPIsfKDNEESVE 852  Dictyo...
XP_643200            773 FLNSKLKPTQYSHTLGILDLFGQESSQLNGYEQFSINFLEERLQQIYLQTVLKQEQREYQTERIPWMTPIsfKDNEESVE 852  Dictyo...

Feature 1                                                                                                
Q86AC8               853 MMEKIINLLDQESKNINSSDQIFLEKLQNFLSRHHLFGKKPNKFGIEHYFGQFYYDVRGFIIKNRDEILQRTNVLHKNSI 932  Dictyo...
WGS:AAFI:DDB0232322  853 MMEKIINLLDQESKNINSSDQIFLEKLQNFLSRHHLFGKKPNKFGIEHYFGQFYYDVRGFIIKNRDEILQRTNVLHKNSI 932  Dictyo...
XP_643200            853 MMEKIINLLDQESKNINSSDQIFLEKLQNFLSRHHLFGKKPNKFGIEHYFGQFYYDVRGFIIKNRDEILQRTNVLHKNSI 932  Dictyo...

Feature 1                                                                                                
Q86AC8               933 TKYLFSRDgvfninatvaelnqmfdaknTAKKSPLSIVKVLLSCGsnnpnnvnnpnnnsgggggggnsgggsgsggSTYT 1012 Dictyo...
WGS:AAFI:DDB0232322  933 TKYLFSRDgvfninatvaelnqmfdaknTAKKSPLSIVKVLLSCGsnnpnnvnnpnnnsgggggggnsgggsgsggSTYT 1012 Dictyo...
XP_643200            933 TKYLFSRDgvfninatvaelnqmfdaknTAKKSPLSIVKVLLSCGsnnpnnvnnpnnnsgggggggnsgggsgsggSTYT 1012 Dictyo...

Feature 1                                                                                                
Q86AC8              1013 TYSSTNKAINNSncDFHFIRCIKPNSKKTHLTFDVKSVNEQIKSLCLLETTRIQRFGYTIHYNNKIFFDRFSFFFQNqrN 1092 Dictyo...
WGS:AAFI:DDB0232322 1013 TYSSTNKAINNSncDFHFIRCIKPNSKKTHLTFDVKSVNEQIKSLCLLETTRIQRFGYTIHYNNKIFFDRFSFFFQNqrN 1092 Dictyo...
XP_643200           1013 TYSSTNKAINNSncDFHFIRCIKPNSKKTHLTFDVKSVNEQIKSLCLLETTRIQRFGYTIHYNNKIFFDRFSFFFQNqrN 1092 Dictyo...

Feature 1                                                 
Q86AC8              1093 FQNLFEKLKENDINIDSILPPPIQVGNTKIFLR 1125 Dictyostelium discoideum
WGS:AAFI:DDB0232322 1093 FQNLFEKLKENDINIDSILPPPIQVGNTKIFLR 1125 Dictyostelium discoideum AX4
XP_643200           1093 FQNLFEKLKENDINIDSILPPPIQVGNTKIFLR 1125 Dictyostelium discoideum AX4

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap