Conserved Protein Domain Family
MYSc_Myo36

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cd14897: MYSc_Myo36 
class XXXVI myosin, motor domain
This class of molluscan myosins contains a motor domain followed by a GlcAT-I (Beta1,3-glucuronyltransferase I) domain. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.
Statistics
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PSSM-Id: 276862
Aligned: 9 rows
Threshold Bit Score: 1018.85
Created: 25-Oct-2013
Updated: 2-Oct-2020
Structure
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Aligned Rows:
  next features
Feature 1:ATP binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                 ###### ##                                            
EKC30269    17 NTIVQALRTRYNREKYYTYIGDILVAVNPCKPIgLFDEKQHEEYTDLv---TRTQRPPHLFWSADHAYRALCNTgRNQCI 93   Pacific oyster
BAB39452    18 ATIKRTLQSRYAKDKIYTYCGDILIAVNPFKDLpIFGKKQHEEYHWKt---LQRMPPPHVFNMAARAYRRIHETrTNQVI 94   Yesso scallop
AAY86556    15 NTIVQALRTRFNKEKFYTYIGDILVAVNPCKPLnLFDLKYHGEYENLv---SRTQKAPHLFWTADNAYRSLCETgRNQCI 91   Atrina rigida
ABQ08059    15 TSIVQTLRCRFNKDIFYTYIGDILVAINPCKPLhLFDEKNHHDYKNLt---VRSQRPPHLFWVADQAFRAMQDTkRNQCI 91   Mediterranean mu...
BAF73720    15 NTIVQAIKSRYNKEKYYTYIGDILVAVNPCKHLtLFDDQYHVEYENLi---TRSKKSPHLFWIADHAYRELCGTgRNQCI 91   Pinctada fucata
ESO85384    17 EILLSSLKSRYKKDKIYSKCGDILIAINPNRPLpIYDAEHHQRFRWQn---ASTQQEPHVFATAALAFQRLVETkTDQVI 93   owl limpet
ESO87527    25 NVILNELKKRYKEEQYYTYLGDVLVALNPNKSIpIFDDKHHEEYSNSsldqTDSNRTPHIFWIAQQAYNRLLATcQNQCI 104  owl limpet
ESO87529    16 NNILQTLKKRYERDRFYTYIGDILVAVNPCKPTnIFDERNHASYSSVs---VRSNNPPHLFWVADQCYRNMLDSgMSQCI 92   owl limpet
ESP01302    12 KTIVENLKQRYIKNEFYTYIGDILLFINPFKTVdIYGKSDHKQYTNVs---VRSNLKPHIFWIADHTHLRMLSShKSQNI 88   owl limpet
Feature 1         ########                                      ### #######                    
EKC30269    94 LVSGESGAGKTESTKYMIRHLMKISPSD-DTQLLDKIVQINPLLEAFGNASTvMNANSSRFGKFIELHYTENGRLLGAKI 172  Pacific oyster
BAB39452    95 LLEGNSGAGKTESTKYMVKHLVSLCPKE-TGDLHERIVKINPLLEAFGNAKTtMNDNSSRFAKYLEMSFATNGQVTGAIV 173  Yesso scallop
AAY86556    92 LVSGESGAGKTESTKYMIQHLMKISPSD-DSLLLDKIVQINPLLEAFGNAATfMNKNSSRFGKFIELHYSEYGQLLGAKI 170  Atrina rigida
ABQ08059    92 LVSGESGAGKTESTKYMIQHLMKLSPSD-DESLLDKIVQINPLLEAFGNASTvMNKNSSRFGKFIELQYAEDGSLLGAKI 170  Mediterranean mu...
BAF73720    92 LVSGESGAGKTESTKYMIRHLMKISPSD-DTRLLDKIVQINPLLEAFGNAATvMNGNSSRFGKFIELHYTEHGKLLGAKI 170  Pinctada fucata
ESO85384    94 LVSGESGAGKTETTKFIIKHIVHLCGNA-QSDLHKKILNINPLMEAFGNARTnLNGNSSRFGKFIQINFDAEGGIQGAVV 172  owl limpet
ESO87527   105 LVSGESGAGKTESTKLAISHLSYMCSTDsNENLQEKIIQINPLLESFGNAVTpMNDNSSRFGKLIELHFTEDGHLSGAKI 184  owl limpet
ESO87529    93 LVSGESGAGKTESSKYIIRHLMHVSSSE-DRQYLDKIVQVNPLLEAFGNASTvVNNNSSRFGKFVELYYKDNGEILGAKF 171  owl limpet
ESP01302    89 VVSGESGSGKTESVKHMISHVTYKSESI-HPFLDVKINEVNPLLEAFGNAQTlMNDNSSRFGKNLELKFTSKGKLAGAVL 167  owl limpet
Feature 1                                                                                      
EKC30269   173 DDYILEKSRVVHRssGEKNFHVFYALFAGMSRERLLYYFLEDPdchrimrdediqngvfrdaeewEHYKAMFSSLTSIMA 252  Pacific oyster
BAB39452   174 RDYLLEKSRVVDQmdKEGNFHIFYCLFAGAPVTVLKNLHLKDArtyrivkg------neelltrtEFYRAMYQEQIEVLK 247  Yesso scallop
AAY86556   171 DDYILEKSRVVHRsnGEKNFHVFYALFAGMSRERLLYYFLEDPdchrimreddvqrgvfqdaeeyQHYKSMFSDLTVIMS 250  Atrina rigida
ABQ08059   171 DDYILEKSRVVHRspGEKNFHVFYALFAGMSRDRLLYYFLEDPdchrimrdddqsssvfkdneeyEYYHQMFTNLTKIMA 250  Mediterranean mu...
BAF73720   171 DDYILEKSRVVHRtcGEKNFHVFYALFAGMSRERLLYYFLEDPdchrimrdeemqcgvfsdseeyEHYRKMFTDLTTIMI 250  Pinctada fucata
ESO85384   173 RDYLLEKSRVVHQpnGEGNFHIFYAFIAGVDPSLKRKLLLDKKsyritk----------nivgdlDYHRNQYNDYLKIMR 242  owl limpet
ESO87527   185 FDYLLEKSRVVHHgsGEQNFHFLYYLFDGLTEDKKKYYYLEDIeqfrvlqng-----rrnkseqvERNKQKFHQQIDIMK 259  owl limpet
ESO87529   172 HDYILEKSRVVHRcrGEKNFHIFYALLAGMSREKLLYYFLEDPnhyrilkdantnqpvfgsknqlLYYKQMYDNLTNIMY 251  owl limpet
ESP01302   168 TDYLLEKSRVVQHgpGERNFHIFYYLFAGMTKDELRNYSLGHPedfrilrndnrnrpvfkstrdlENSRLMFHKQLNVMK 247  owl limpet
Feature 1                                                                                      
EKC30269   253 QTGFSEEHIQVIFLILAAILHLANIVFmpiee-tdgvsVADEYPLHAVAKLLGIdDEVELTEALISNVSTIKGERiqswK 331  Pacific oyster
BAB39452   248 SINLEQEDIDIIHTILAAILLITQVEFlepddpnepmkIKDTTFVENVADLLNV-SYEDLGHALIATKQTYVGETlvkrK 326  Yesso scallop
AAY86556   251 HIGFSDEHIQVIFLILAAILHLANIVFmpids-tdgvsVADEYPLHAVAKLLGIeDEVELTEALISNVNTIKGEKiqswK 329  Atrina rigida
ABQ08059   251 EIGFSEEHISVIFLVLAAVLHLANIQFvtcee-tdgvtVADEYPLHAVAKLLGIeDEVELTEALISNVNYIKGERiqswK 329  Mediterranean mu...
BAF73720   251 QIGFSEEHIQVIFLILAAILHLANIVFmpiet-tdgvtVADEYPLHAVAKLLGIeDEVELTEALISNVSNIKGEKiqswK 329  Pinctada fucata
ESO85384   243 LIKLPKEDIEAVQIILAAILHITEIRFeedgd-sqgvvVSNEDEMINAASLLGV-DPDKFGKSLVLEDIVLPDETittfK 320  owl limpet
ESO87527   260 MIGFSEEDISSILTLLSAILNVTNLVFvddte-vdgvnIENEFHLRVATSFLGI-EIEELTTALISSTIFVRGERvetlK 337  owl limpet
ESO87529   252 QIGFTEEDLTFIHMTISAILNLANIEFipnld-aegvtIADDYPLKAVCNLLRIsDTQGFMDALVSQVNIIRGESfrcpK 330  owl limpet
ESP01302   248 LVGFTDWEISMVFTVLSAVLHVTNIVYikdek-tekarFADLKNLEIVAVLLQI-DIVDLSDVLISSANYTRGERlvihR 325  owl limpet
Feature 1                                                         ######                       
EKC30269   332 SLREANDSRDALAKDLYSRLFGWIVGQINRNIWPNQrrqsqlTRGSSIGLLDLSGFENFKqNGFDQLLINISNEKLQQYF 411  Pacific oyster
BAB39452   327 SMYQAIDSRDAFAKALYERIFGWIVRQINLNLHPSKfk--apTGSTSIGILDIAGFERLEiNSMEQMCINLINERLQSFT 404  Yesso scallop
AAY86556   330 SLREANDSRDALAKDLYSRLFGWIVGQINRNIWGKRqnknkmTRGSSIGLLDMSGFENFKvNGFDQLLINISNEKLQQYF 409  Atrina rigida
ABQ08059   330 NFRDANNSRDALAKDLYSRLFGWIVGQINRKIWTAKkrqsnmARGPSISLLDLSGFENFTnNSFDQFFINASNERLQQYF 409  Mediterranean mu...
BAF73720   330 SLREANDSRDALAKDLYSRLFGWIVGQVNRNIWPQRrks-imTRGPSIGLLDMSGFENFRlNGFDQFLINISNEKIQQYF 408  Pinctada fucata
ESO85384   321 SLEQAEDGRDALAKSLYERLFGWMIQNINVSLHTQQdf--gaERMGSLGILDICGFEIMRnNGLEQLCINLVNEQLQSFM 398  owl limpet
ESO87527   338 KKHQAEDCRDTIAKILYSRLFGWIVGQINVHLKPKTd----nGRNSTVSILDLAGFECLPmNTFDQLCINAANERLQQYF 413  owl limpet
ESO87529   331 NEREANNSRDALCKELYARLFGWIVGQINRNLSSDSllnrnsTDGPSIGLLDMSGFENFErNSFDQFLINVSNERLQQHF 410  owl limpet
ESP01302   326 TVEQAAESRDALAKALYSRLFGWIVRQINTRLKPDKefryikYSGPSLGILDMPGFENLKiNSLEQLCINVANEQMQTYF 405  owl limpet
Feature 1                                                                                      
EKC30269   412 MDYIFPREKKDYEaEGIEWRDIvYHSNDDVLELVFKRD-GILSLLDEEShFPQSNDSSLVQKLNKYCKDSTRYaatmgnr 490  Pacific oyster
BAB39452   405 NRNVMDYEMSIYKeEGIHVTGIkFKNNDALLDLFMKKTfGLLPLLDEESkLGQGSNERFVKKLNDKYDTHPCFtesphgr 484  Yesso scallop
AAY86556   410 MDYIFPRERREYElEGIEWRDIvYHCNDEVLEVLFKRPdGVLSLLDEEShFPQSNDSSLVQKLNKYCHDSTRYvaqmgnr 489  Atrina rigida
ABQ08059   410 MEYIFPREQREYDiEGIEWRNImYHSNDDVLDLLFKKPdGILSLMDEEShFPQSSDKSFVQKLNKYCSESDRYipslrnk 489  Mediterranean mu...
BAF73720   409 MDYIFPRERREYEiEGIEWRDIeYHCNDDVLELIFKKPdGILPLLDEESnFPQSTDNSFVQKINKYCEENPRYvanvynk 488  Pinctada fucata
ESO85384   399 NKQVFIKEQEIYEsEGLTLEDVnYPDNAKIIEMFTMNRyGIIALIDEDTtFAQATSMSLITKLQDKWGHHDHFvspvydi 478  owl limpet
ESO87527   414 YDKIFKYERSDYEkEGVDVSLVeFQDNQDLIDLFFKKPlGLFYLIDEESsLPRANDKSLVQKLENICGSSPHYktvpgdq 493  owl limpet
ESO87529   411 MDYVFPREQKEYEiEGINWTDItYRSNEDVLELIFLKSyGILPLLDEEStFPQSSDASLVHKLNRYCSPNDRYippkgnh 490  owl limpet
ESP01302   406 NEHVFVLDRQEYErEGLSWKNIqYRNNNDLLNLFMMKPlGIFALMDEEIrFPRSTDSSLVEKITTHCKNTKLVsksksgd 485  owl limpet
Feature 1                                                                                      
EKC30269   491 vAFSIRHYAEQVTYDADGFLERNRDKLSQDLVGCLLNSNNNFIKDLFtasisetgtisdfaskctsrpklpavwpsqidp 570  Pacific oyster
BAB39452   485 vEFGVRHFAAQVWYDGSLFIEKNRDMLSQDVTSCMRESDNPFVSDLFtvkkgptgtisatmqnirrsrkaegrgprkpit 564  Yesso scallop
AAY86556   490 vCFGIRHYAEQVTYNADGFLEGNRDSLSSDLVGCLLNSNNEFIKDLFtasmsptgtisdfaskcasrprlpsvwpstinp 569  Atrina rigida
ABQ08059   490 tCFEIQHYAEQVVYNADGFLERNRDNLSSDLVGCMLNSNNEFIKDLFtasmsptgtisdfaskcssrprlpsiwpsaidp 569  Mediterranean mu...
BAF73720   489 pVFTVKHYAEQVQYDANGFLERNRDTLSADLVGCLLNSNNEFIKDLFtasmsptgtisdfaskcssrpklptiwpstiea 568  Pinctada fucata
ESO85384   479 pEFGIKHFAGEVTYDADDFIEKNADNLSSGIFSCIQDSENDLISDLFkvqkcltgsisalns------------------ 540  owl limpet
ESO87527   494 aAFTISHYAGKVSYCAKGMVEKNRDSISQNVLDCLLKSSNDMVQMLFspsqqemgscsrafgatllkpqapsrpvieitd 573  owl limpet
ESO87529   491 cIFGVSHYAEKVYYDAEGFLERNRDKLSSDIVNCLVNCQNEFIRELLtaslsatgtisdfaskstsrptlpqswpnigqq 570  owl limpet
ESP01302   486 lAFCVHHYVGTVEYHAAGFLEKNRDNLSICIVDCMKSSQSQLISDLFkaklsrtgtisgfiafcatiplqriynkhrlan 565  owl limpet
Feature 1                                                                                      
EKC30269   571 erl--rrslsrkvsnrikksrelsgesskysslgrasptvTKHFKRSLSDLMTKLSQAQPLFVRCIKPNhfLSSGKFDTE 648  Pacific oyster
BAB39452   565 ar---gqllmadlgrslkerygesvqstnqvynpkdhktvISYFQSSMNELLQKLQRADPYYVRCIKPNmfLKPDNFDDE 641  Yesso scallop
AAY86556   570 eklrvslsgkasirikkksfrnlsgessgstlyarssptvTKHFKRSLSDLMTKLSQAQPLFVRCVKPNlhLSSGKFDSD 649  Atrina rigida
ABQ08059   570 dk---lreslsrqaslrikrrsiscdsiastingrssptvTNHFKRSLSDLMTKLTQSQPLFVRCIKPNktIAADKFETE 646  Mediterranean mu...
BAF73720   569 hs---lreslsrkastrikrrrdlsgdsrtsiagnssptvTRHFKRSLTDLMTKLSQAQPLFVRCIKSNqhLAANKFDSE 645  Pinctada fucata
ESO85384   541 --------------------------nmrpqktsqdhktqLSYFTESIKDLLRKMNSADPLFIRCIKPNneQREKLFVDE 594  owl limpet
ESO87527   574 -------gdksiskataeklkrkslnksnngseiqtksfvSRYFRKSLDDLMTKISSVNPWFVRCVRPNskNRANSFDAE 646  owl limpet
ESO87529   571 d------nnvsspvfqhtslnersssssslstslrskptvTSHFKRSLADLISKLNRAQPLFVRCVKPNttLAPNQFDTE 644  owl limpet
ESP01302   566 k-----qvifyhkkrfgqkltnvlcsncrydrslknqttvAQYFKNSLVDLMTRMNSSDPSFVRCIKPNdqKVPEKFQHD 640  owl limpet
Feature 1                                                                                    
EKC30269   649 LTRRQLLCNGLMEIAELRREGYPVRIRYEDFVKRYAELcpplpnva----ddvsislgILKGADIEGFGTGRSKLFLK 722  Pacific oyster
BAB39452   642 KVLEQMLYNGISEVAKIRKLGLPIRKRYDDFTKRYRPLfldcrkarsdragaelllkkTLPDKMMSGIQFGKTRVFMQ 719  Yesso scallop
AAY86556   650 LVRRQLLCNGLMEIAELRRDGYPIRIKFEDFAARYKDIcdfgntns----ddlgkcldILKTERIEGFKVGRSKIFLK 723  Atrina rigida
ABQ08059   647 LVRRQMLCNGLMEIAELRRYGYPVRVKFEDFAARYAMLcdssdemy----gdfgrcvdILKAAHIEGAQFGKSKIFMK 720  Mediterranean mussel
BAF73720   646 LVRRQLLCNGLMEIAELRRDGYPIRIKYEDFVERYRDIsdfvnpks----ddlgqtlvILKSLNIEGFKAGRSKIFLK 719  Pinctada fucata
ESO85384   595 KVNEQLSYLGIKEIAKIRKMCYPIRSQYTDFSQWYKDIvptseksrs--dadqskfilNKFIKSNKEYKFGKTQIFMM 670  owl limpet
ESO87527   647 LVMNQLRCNGLLEITKIRRDGFAIRIPVQDFVKSYREIcykakevlp---dpwqaaqkIMQVAKAKDYVFGHTKVFLR 721  owl limpet
ESO87529   645 LVRRQLRCNGLMEITQLRRDGFPIRIHYQDFSERYGELlnnldledvgtgsiltrcqeICDKNGIKDYQLGRTKVFLK 722  owl limpet
ESP01302   641 QVVNQLRSSGVFEVSRIRQTDYPIRMAFGKFIDRYKIIgfrpnmyve---pkpincvaILKTLGLSDFETGQTKVFLR 715  owl limpet

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