Conserved Protein Domain Family
MYSc_Myo21

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cd14882: MYSc_Myo21 
class XXI myosin, motor domain
The myosins here are comprised of insects. Leishmania class XXI myosins do not group with them. Myo21, unlike other myosin proteins, contains UBA-like protein domains and has no structural or functional relationship with the myosins present in other organisms possessing cilia or flagella. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. They have diverse tails with IQ, WW, PX, and Tub domains. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.
Statistics
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PSSM-Id: 276848
Aligned: 17 rows
Threshold Bit Score: 1142.55
Created: 7-Jan-2013
Updated: 2-Oct-2020
Structure
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Aligned Rows:
  next features
Feature 1:ATP binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                 #### ####                                           #
EGI60548   382 DVILDELRDRLRRGEYHTFIGDILLILNPNEeNDIYGVHHHAKYQCKSRSDNAPHIYSVADSAFQDVMLNEELQHILLAG 461  Panamanian leafc...
EFN88873   388 DVILDELRERLQRAEYHTFVGDILLILNPNEqHGIYDVHHHAKYQCKSRSDNAPHIYSVADSAFQDVMHNEEPQHILLAG 467  Harpegnathos sal...
EFN72913   120 DVILDELCERLKRGEYHTFVGDVLLILNPNEeRVIYDAYHHMKYQCKSRSDNAPHIYSVADSAFQDVMHNEEPQHILLAG 199  Camponotus flori...
EFZ14256   376 DIILNELRERLERGEYHTFIGDILLVLNPNEeHDIYGDHHHAKYQSKSRSDNAPHIYSVADSAFQNVMLNEDSQHILLAG 455  red fire ant
ETN65570   348 ETILEELVQRYRNGNTYTFVGDVLVSLNPNEtIPEYVRGFHSKYMFKSRSDNAPHVFAIADSAYQDMLHHEEPQHIILAG 427  Anopheles darlingi
EAT48353   346 ETILEELIQRYKSGSTYTFVGDVLISMNANQpPPEYVRGFHTKYMCKSRSDNAPHIFAIADSAFQDMLHHEEPQHIIMSG 425  yellow fever mos...
NP_523503  346 ENIIESLRHRILMGESYSFIGDILLSLNSNEiKQEFPQEFHAKYRFKSRSENQPHIFSVADIAYQDMLHHKEPQHIVLSG 425  fruit fly
NP_723271  346 ENIIESLRHRILMGESYSFIGDILLSLNSNEiKQEFPQEFHAKYRFKSRSENQPHIFSVADIAYQDMLHHKEPQHIVLSG 425  fruit fly
P10676     346 ENIIESLRHRILMGESYSFIGDILLSLNSNEiKQEFPQEFHAKYRFKSRSENQPHIFSVADIAYQDMLHHKEPQHIVLSG 425  fruit fly
AAM50150   346 ENIIESLRHRILMGESYSFIGDILLSLNSNEiKQEFPQEFHAKYRFKSRSENQPHIFSVADIAYQDMLHHKEPQHIVLSG 425  fruit fly
Feature 1      #######                                     ###########                         
EGI60548   462 ESNSGKTTNMLHLVEHLMFLGKGlhDTGARVLq-AIKIIHAFTNAGTPLNADSTRCILQTQTTFGSTGKASGAIFWLYQL 540  Panamanian leafc...
EFN88873   468 ESNSGKTTNMLHLVEHLAFLGKGmhNVGMRVMr-SIKIIHAFTNASTLLNADSTRCILQVQMTFGSTSKTSGAIFWPYQL 546  Harpegnathos sal...
EFN72913   200 ESNSGKTTNMLHLIKHLMFLGKGlqDTGMRVLr-AIQIIHAFTNAATPLNANSTRCILQIQTTFGSTGKASGAIFWLYQL 278  Camponotus flori...
EFZ14256   456 ESNSGKTTNMLHLMEHLMFLGKGl-RDTGAIVlrAIKIIHAFTNAATPLNANSTRCILQTQTTFGSTGKASGAIFWLYQL 534  red fire ant
ETN65570   428 ESYSGKTTNLKLLMKHLGVLGEGnpGVYERIVn-GYKALCALTNAGTPINPNSTRSIMQVQMTFGPSGKLSGAIFWVYLL 506  Anopheles darlingi
EAT48353   426 ESYSGKTTNVKMCIKHLSILGEGnpGVYQKIEs-GYKVMSALVNAGTPLNSDSTRSIVQTQLTFGSTGKLSGAIFWVYLL 504  yellow fever mos...
NP_523503  426 ESYSGKSTNARLLIKHLCYLGDGnrGATGRVEs-SIKAILMLVNAGTPVNNDSTRCVLQYCLTFGKTGKMSGAVFNMYML 504  fruit fly
NP_723271  426 ESYSGKSTNARLLIKHLCYLGDGnrGATGRVEs-SIKAILMLVNAGTPVNNDSTRCVLQYCLTFGKTGKMSGAVFNMYML 504  fruit fly
P10676     426 ESYSGKSTNARLLIKHLCYLGDGnrGATGRVEs-SIKAILMLVNAGTPVNNDSTRCVLQYCLTFGKTGKMSGAVFNMYML 504  fruit fly
AAM50150   426 DSYSGKSTNARLLIKHLCYLGDGnrGATGRVEs-SIKAILMLVNAGTPVNNDSTRCVLQYCLTFGKTGKMSGAVFNMYML 504  fruit fly
Feature 1                                                                                      
EGI60548   541 EKWRVSTRDRNQANFHVFYYFYDDLEATENLKSYflpsgrklrylritdkniekkrafkvRSDPQNNVIKFKELTEYFKF 620  Panamanian leafc...
EFN88873   547 EKWRVSTRDRNQSNFHAFYYLYDGLEASGRLKKYylpsgrrlrylritdksaerkrafkvRHDPHNNVLEFEKLTEGLKY 626  Harpegnathos sal...
EFN72913   279 EKWRVSTRDRNQSNFHAFYYLYDGFDASGKLKDYylpngrrlrylritdkniekkrafkvRNDPEHNVVKFEELIEHFKF 358  Camponotus flori...
EFZ14256   535 EKWRVSTRDRNQSNFHIFYYFYDGLEASENLQTYflpsgrklrylriidkgtekkrgfkvRNDPQNNAIKLKELEECFKY 614  red fire ant
ETN65570   507 EKLRISSTNMNHSNFHIFYYFYDTMDAEERLKDFslesgrnyrylri-seamssdklkycRDDVQGNVRSFKEFEQQLLG 585  Anopheles darlingi
EAT48353   505 EKLRISSTNMNQSNFHIFYYFYDTMEAEERLRDFslasgrhyrylri-pesnggsklrycRDDVAGNIRAFKEFEQLLLE 583  yellow fever mos...
NP_523503  505 EKLRVATTDGTQHNFHIFYYFYDFINQQNQLKEYnlkadrnyrylrv-ppevppsklkyrRDDPEGNVERYREFENILRD 583  fruit fly
NP_723271  505 EKLRVATTDGTQHNFHIFYYFYDFINQQNQLKEYnlkadrnyrylrv-ppevppsklkyrRDDPEGNVERYREFENILRD 583  fruit fly
P10676     505 EKLRVATTDGTQHNFHIFYYFYDFINQQNQLKEYnlkadrnyrylrv-ppevppsklkyrRDDPEGNVERYREFENILRD 583  fruit fly
AAM50150   505 EKLRVATTDGTQHNFHIFYYFYDFINQQNQLKEYnlkadrnyrylrv-ppevppsklkyrRDDPEGNVERYREFENILRD 583  fruit fly
Feature 1                                                                                      
EGI60548   621 MDm-EEYCDTIWKILAAILILGEIRFvegnngeaeLDDNEIANRVAELLGLNSKKFIWALINYCLVvkGSVVRKKHTCEE 699  Panamanian leafc...
EFN88873   627 MDm-EEYCETIWRTLAAILLLGEIRFvegnngeaeLENNEAANNVAQLLGLDSKKFIWALVNYCLIvkGSAMRRKHTCEE 705  Harpegnathos sal...
EFN72913   359 MDm-EEHCETIWKILAAILILGEIRFvegnngeaeLDNNEAANRVAELLGLDSKKFIWALINYCLIvkGSAMRRKHTCEE 437  Camponotus flori...
EFZ14256   615 MDi-EEHCEIIWKILAAILILGEIRFvegnngeaeLDNNEIATRVAKLLGLDEKKFIWALVNYCLIvkESAIRRKHTYEE 693  red fire ant
ETN65570   586 LElsQNILDTIYRTLAAILILGEVRFkete-gmteLEDFEVIGKIASLLQVDEKKFQWALLNYCVIvrGSAERRRHTADE 664  Anopheles darlingi
EAT48353   584 LEltPDLLETVYRTLAAILLLGEVRFrdne-gvteLEDFEVATKVAALLKLDEKKFQWALLNYCVIirGSAERRRHSADE 662  yellow fever mos...
NP_523503  584 IDfnHKQLETVRKVLAAILNIGNIRFrqng-kyaeVENTDIVSRIAELLRVDEKKFMWSLTNFIMVkgGIAERRQYTTEE 662  fruit fly
NP_723271  584 IDfnHKQLETVRKVLAAILNIGNIRFrqng-kyaeVENTDIVSRIAELLRVDEKKFMWSLTNFIMVkgGIAERRQYTTEE 662  fruit fly
P10676     584 IDfnHKQLETVRKVLAAILNIGNIRFrqng-kyaeVENTDIVSRIAELLRVDEKKFMWSLTNFIMVkgGIAERRQYTTEE 662  fruit fly
AAM50150   584 IDfnHKQLETVRKVLAAILNIGNIRFrqng-kyaeVENTDIVSRIAELLRVDEKKFMWSLTNFIMVkgGIAERRQYTTEE 662  fruit fly
Feature 1                                                  ######                              
EGI60548   700 AKEARDVLANTLYQRLVDWIINIINYKLSMTRSLYGDKYSISILDHFGFECFSINRLEQLLVNTINEQIQYYYNQRVFAW 779  Panamanian leafc...
EFN88873   706 AKEARDVLANTLYQRLVDWIINNINYKLTMTRSLYGDKYSISVLDLFGFECFSINRVEQLVVNTMNEQMQYHYNQRVFAW 785  Harpegnathos sal...
EFN72913   438 AKEARDVIANTLYQRLVDWIINVINYKLLMTRSLYGDKYSISILDYFGFECFSVNRLEQLLINTMNEQMQYYYNQRIFTW 517  Camponotus flori...
EFZ14256   694 AKEARDVLANTLYQRLVDWIINIINYKLSMTRSLYGDKYSISIFDYFGLECFSVNRLEQLLVNTINEQMQYYYNQRVFAW 773  red fire ant
ETN65570   665 ARDARDVLAATIYTRLVDWITNTVNQKLAFGRAIYGDKHSVTITDHFGFECFHRNHIDQLVVNSLNEQMQYLYNQRIFVF 744  Anopheles darlingi
EAT48353   663 ARDARDVLAATIYTRLVDWLINTINHKMSFGRAIYGDQHSITITDHFGFECFHRNHIDQLVVNSLNEQMQYLYNQRIFVY 742  yellow fever mos...
NP_523503  663 ARDARDAVASTLYSRLVDFIINRINMNMSFPRAVFGDTNAIIIHDMFGFECFNRNGLEQLMINTLNEQMQYHYNQRIFIS 742  fruit fly
NP_723271  663 ARDARDAVASTLYSRLVDFIINRINMNMSFPRAVFGDTNAIIIHDMFGFECFNRNGLEQLMINTLNEQMQYHYNQRIFIS 742  fruit fly
P10676     663 ARDARDAVASTLYSRLVDFIINRINMNMSFPRAVFGDTNAIIIHDMFGFECFNRNGLEQLMINTLNEQMQYHYNQRIFIS 742  fruit fly
AAM50150   663 ARDARDAVASTLYSRLVDFIINRINMNMSFPRAVFGDTNAIIIHDMFGFECFNRNGLEQLMINTLNEQMQYHYNQRIFIS 742  fruit fly
Feature 1                                                                                      
EGI60548   780 EMQEQEEEDIPIQQLRFYDNKEAVDQLMnKRDGLFHIIDDASRQMQDAQYILERIKEhkRNTHIKPVSSHEFMIAHYTGK 859  Panamanian leafc...
EFN88873   786 EMQEQEEEEIPVQRLRFYDNKEAIDQLMnKTNGLFHIIDDASRQMQDAQYILERIKErkRGTYVKPVSSHEFTVAHYTGK 865  Harpegnathos sal...
EFN72913   518 EMQEQNEEDIPIKRFRFYDNKEAVDQLMsKENGLLRIIDDASRQLQDAQYIFERIKEhkRGIYIKPVSSHEFTVAHYTGK 597  Camponotus flori...
EFZ14256   774 EMQEQEEEDIPMRQLRFYDNKEAVDQLMsKKDGLFHIIDDASRQMQDAQYILERIKEhkRGIHVKPVSSHEFTVAHYTGK 853  red fire ant
ETN65570   745 EMIEMEEEQVPMASLHYYDNKLAVDHILtKPKGVFSYIDDASRGRHGQNYIIDSIQSn-KSPFIKRSSGHEFTVAHYTGR 823  Anopheles darlingi
EAT48353   743 EMIEQEEEQVPVVQLHFYDNKLAVDHLMnKPKGLLSFIDDASRGRHSQNYIIDSIHSn-NSPFIKRASGHEFSIAHYTGR 821  yellow fever mos...
NP_523503  743 EMLEMEAEDIDTINLNFYDNKTALDNLLtKPDGLFYIIDDASRSCQDQDLIMDRVSEk-HSQFVKKHTATEISVAHYTGR 821  fruit fly
NP_723271  743 EMLEMEAEDIDTINLNFYDNKTALDNLLtKPDGLFYIIDDASRSCQDQDLIMDRVSEk-HSQFVKKHTATEISVAHYTGR 821  fruit fly
P10676     743 EMLEMEAEDIDTINLNFYDNKTALDNLLtKPDGLFYIIDDASRSCQDQDLIMDRVSEk-HSQFVKKHTATEISVAHYTGR 821  fruit fly
AAM50150   743 EMLEMEAEDIDTINLNFYDNKTALDNLLtKPDGLFYIIDDASRSCQDQDLIMDRVSEk-HSQFVKKHTATEISVAHYTGR 821  fruit fly
Feature 1                                                                                      
EGI60548   860 LIYDANEIATKNRDFVPPEMINTMRYSLHNAVKEMFTNkltksgnltivhehcfatkktmkt----kwstlmqessmfrk 935  Panamanian leafc...
EFN88873   866 LIYDANEIAGKNRDFLPPEMVGTMRFSSYDAVKQMFTNkltksgnltiiqgnsvaaetektsk--skwgalmqestrlrr 943  Harpegnathos sal...
EFN72913   598 LIYDASEIAAKNRDFVPPEMISTMRFSSCDVVKQMFTNkltksgsltiihesclakknkw--------salmqessnfrk 669  Camponotus flori...
EFZ14256   854 LIYDASEIATKNRDFVPPEIIDTMRLSSHDAVKQMFTNkltksgnltivhesclagntpkk-----kwnvlmqessavrk 928  red fire ant
ETN65570   824 VTYDARDMADKNRDFIPPEMVETLRASEEPIIKIMFSNqlsrtgnltmaaeealgvpsdkptkkkrwgaalvaeknkakk 903  Anopheles darlingi
EAT48353   822 ITYDARDMADKNRDFIPPEMIETLRNSTEPVVTIMFSNqlsrtgnltmaaeealgkqtqk-------pnkkkrwgaalkm 894  yellow fever mos...
NP_523503  822 IIYDTRAFTDINRDFVPPEMIETFRSSLDESIMLMFTNqltkagnltmpfeavqhk---------------deserksya 886  fruit fly
NP_723271  822 IIYDTRAFTDINRDFVPPEMIETFRSSLDESIMLMFTNqltkagnltmpfeavqhk---------------deserksya 886  fruit fly
P10676     822 IIYDTRAFTDINRDFVPPEMIETFRSSLDESIMLMFTNqltkagnltmpfeavqhk---------------deserksya 886  fruit fly
AAM50150   822 IIYDTRAFTDINRDFVPPEMIETFRSSLDESIMLMFTNqltkagnltmpfeavqhk---------------deserksya 886  fruit fly
Feature 1                                                                                      
EGI60548   936 yntaskgqySQTRKMRTCSSTFRATSLEILKNLAIGtgngGTHFVRCIRSDLEDAPHSFYREIVRQQIRALAVLDTAKAR 1015 Panamanian leafc...
EFN88873   944 yntasrgqySQTRKMRTCSSTFRATSLEILKNLAVGtgnsGMHFVRCIRSDLEDTPRGFYREVVKQQIRALAVLDTAKAR 1023 Harpegnathos sal...
EFN72913   670 yntasrgqySQTRKMRTCSSTFRATSLEILKNLAISag-sGTHFVRCIRSDLEDVPCGFYREVVRQQIRALAVLDTAKAR 748  Camponotus flori...
EFZ14256   929 yniasrgqySQTRNMKTCSATFRATSLEILKNLVIGtgngGTHFVRCIRSDLEDVPHSFYREIVRQQIRALAVLDTAKAR 1008 red fire ant
ETN65570   904 mntlskgmySQVHKMRTIAGVFRATSLELIKTLSIGpnsgGTHFVRCIRSDLEYKPKGFATEMVRQQVRAMAVLDTARGR 983  Anopheles darlingi
EAT48353   895 mntlsrgqySQVHKMRTIANVFRATCLELIRTLAIGpnsgGTHFVRCIRSDLEYQPNGLSKEMIRQQVRAMAILDTVKAR 974  yellow fever mos...
NP_523503  887 lntlsagciSQVNNLRTLAANFRFTCLTLLKMLSQNan-lGVHFVRCIRADLEYKPRSFHSDVVQQQMKALGVLDTVIAR 965  fruit fly
NP_723271  887 lntlsagciSQVNNLRTLAANFRFTCLTLLKMLSQNan-lGVHFVRCIRADLEYKPRSFHSDVVQQQMKALGVLDTVIAR 965  fruit fly
P10676     887 lntlsagciSQVNNLRTLAANFRFTCLTLLKMLSQNan-lGVHFVRCIRADLEYKPRSFHSDVVQQQMKALGVLDTVIAR 965  fruit fly
AAM50150   887 lntlsagciSQVNNLRTLAANFRFTCLTLLKMLSQNan-lGVHFVRCIRADLEYKPRSFHSDVVQQQMKALGVLDTVIAR 965  fruit fly
Feature 1                                                               
EGI60548  1016 RRGYPYRIPFQEFLRRYKFLAFDFDETVEMTKDNCRLLLIRLKmeGWIIGKSKIFLK 1072 Panamanian leafcutter ant
EFN88873  1024 QRGYPYRIPFQEFLRRYKFLAFDFDETVEMTKDNCRLLLIRLKmeGWIIGKTKVFLK 1080 Harpegnathos saltator
EFN72913   749 QRGYPYRIPFQEFLRRYKFLAFDFNETVEMTKDNCRLLLIRLKmeGWIIGKTKVFLK 805  Camponotus floridanus
EFZ14256  1009 RCGYPYRIPFQEFLRRYKFLAFDFDETVETTKDNCRLLLIRLKmeGWIIGKTKVFLK 1065 red fire ant
ETN65570   984 QKGFSHRIPFQEFLRRYQFLAFDFDENVEMTRDNCRLLLIRLKleGWVIGKTKVFLK 1040 Anopheles darlingi
EAT48353   975 QKGFSHRIPFQEFLRRYQFLAFEFDENVEMTRDNCRLLLIRLKleGWVIGKTKVFLK 1031 yellow fever mosquito
NP_523503  966 QKGFSSRLPFDEFLRRYQFLAFDFDEPVEMTKDNCRLLFLRLKmeGWALGKTKVFLR 1022 fruit fly
NP_723271  966 QKGFSSRLPFDEFLRRYQFLAFDFDEPVEMTKDNCRLLFLRLKmeGWALGKTKVFLR 1022 fruit fly
P10676     966 QKGFSSRLPFDEFLRRYQFLAFDFDEPVEMTKDNCRLLFLRLKmeGWALGKTKVFLR 1022 fruit fly
AAM50150   966 QKGFSSRLPFDEFLRRYQFLPFDFDEPVEMTKDNCRLLFLRLKmeGWALGKTKVFLR 1022 fruit fly

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