Conserved Protein Domain Family
MYSc_Myo16
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cd14878: MYSc_Myo16 
class XVI myosin, motor domain
These XVI type myosins are also known as Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 3/NYAP3. Myo16 is thought to play a regulatory role in cell cycle progression and has been recently implicated in Schizophrenia. Class XVI myosins are characterized by an N-terminal ankyrin repeat domain and some with chitin synthase domains that arose independently from the ones in the class XVII fungal myosins. They bind protein phosphatase 1 catalytic subunits 1alpha/PPP1CA and 1gamma/PPP1CC. Human Myo16 interacts with ACOT9, ARHGAP26 and PIK3R2 and with components of the WAVE1 complex, CYFIP1 and NCKAP1. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.
Links
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Statistics
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PSSM-Id: 276844
Aligned: 17 rows
Threshold Bit Score: 1226.6
Created: 7-Jan-2013
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1:ATP binding site [chemical binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                    #########                                            
ELK24949      415 GSLLYEIQKRFGNNQIYTFIGDILLLVNPFKELPIYSTMVSQLYRSSTGQpcsSLPPHLFSCAERALHQLFQEQRPQcfi 494  Myotis davidii
NP_001185879  437 GSLLYEIQKRFGNNQIYTFIGDILLLVNPYKELPIYSSMVSQLYFSSSGKlcsSLPPHLFSCVERAFHQLFREQRPQcfi 516  human
ELR50107      415 SSLLYEIQKRFGNNQIYTFIGDILLLVNPFKEIPIYSTVVSELYLSSTGQpnpSLPPHIFCCAERAFHQLFQERRPQcfv 494  Bos grunniens...
ERE91016      444 SSLLYEIQKRFGNDQIHTFIGDIFLLVNPFKELPIYSTMVSQLYLSLTGQrspSLPPHLFSCAERAFHRLFQERRPQnii 523  Chinese hamster
NP_001074866  414 SSLLYEIQKRFGNDQIHTFIGDIFLLVNPFKELPIYSTMVSQMYLSPTGQrspSLPPHLFSCAERAFHRLFQERKPQnii 493  house mouse
Q5DU14        414 SSLLYEIQKRFGNDQIHTFIGDIFLLVNPFKELPIYSTMVSQMYLSPTGQrspSLPPHLFSCAERAFHRLFQERKPQnii 493  house mouse
AAF20150      415 SSLLYEIQKRFGNDQIHTFIGDIFLLVNPFKELPIYSTVVSQMYLSPTGQrspSLPPHLFSCAERAFHRLFQERRPQnii 494  Norway rat
NP_620248     415 SSLLYEIQKRFGNDQIHTFIGDIFLLVNPFKELPIYSTVVSQMYLSPTGQrspSLPPHLFSCAERAFHRLFQERRPQnii 494  Norway rat
Q9ERC1        415 SSLLYEIQKRFGNDQIHTFIGDIFLLVNPFKELPIYSTVVSQMYLSPTGQrspSLPPHLFSCAERAFHRLFQERRPQnii 494  Norway rat
XP_416950     437 SSLLYEIQKRFNNNQIYTYIGDKLLLVNPFKELPIYSTMVTQLYLSNSGKlcsTLPPHIFSCAERAYHMLFQEQRPQcfi 516  chicken

Feature 1           ########                                     ###########                      
ELK24949      495 lsGERGSGKTEASKQIIRHLTCRSGTSRpiFDSKFKHVMCILEAFGHAKTTLNDLSSCFIKYFELQFCeRKKQLTGARIY 574  Myotis davidii
NP_001185879  517 lsGERGSGKSEASKQIIRHLTCRAGASRatLDSRFKHVVCILEAFGHAKTTLNDLSSCFIKYFELQFCeRKQQLTGARIY 596  human
ELR50107      495 lsGERGSGKSEASKQIMRHLTCRSGSSRpiFDSKFKHVMSILEAFGHARTTLNDLSSCFIKYFELQFCeRKKHLTGARIF 574  Bos grunniens...
ERE91016      524 isGERGSGKTQASKQIMRHLTGRASSSCtmFDSRFKHAMCILEAFGHAKTTLNNVSSCLIQYWELQFCeRRKHATGARIS 603  Chinese hamster
NP_001074866  494 lsGERGSGKTQASKQIMKYLTSRASSSCtmFDSRLRHAIYIVEAFGHAKTTLNNVSSCLIQYWELQCCqRRKHITGARIS 573  house mouse
Q5DU14        494 lsGERGSGKTQASKQIMKYLTSRASSSCtmFDSRLRHAIYIVEAFGHAKTTLNNVSSCLIQYWELQCCqRRKHITGARIS 573  house mouse
AAF20150      495 lsGERGSGKTQASKQIMKHLTSRASSSCtmFDSRFKHAICILEAFGHAKTTLNNVSSCLIQYWELQFCqRRKHVTGARIS 574  Norway rat
NP_620248     495 lsGERGSGKTQASKQIMKHLTSRASSSCtmFDSRFKHAICILEAFGHAKTTLNNVSSCLIQYWELQFCqRRKHVTGARIS 574  Norway rat
Q9ERC1        495 lsGERGSGKTQASKQIMKHLTSRASSSCtmFDSRFKHAICILEAFGHAKTTLNNVSSCLIQYWELQFCqRRKHVTGARIS 574  Norway rat
XP_416950     517 lsGESGSGKTEACKQIVKHLTCRSSSSRstFDTKIKHVNCVLEAFGHAKTPLSDFSSCFIKYFELQFCeKKKALIAARIY 596  chicken

Feature 1                                                                                         
ELK24949      575 TYMLEKSRLISQPLGQSNFLIFYLLMDGLSAEEKYGLHLNNLCAHRYLNQTLRDDlstaehsLNRERFAVLKQALNVVGF 654  Myotis davidii
NP_001185879  597 TYLLEKSRLVSQPLGQSNFLIFYLLMDGLSAEEKYGLHLNNLCAHRYLNQTIQDDastgersLNREKLAVLKRALNVVGF 676  human
ELR50107      575 TYMLEKSRLVSQPPGQSNFLIFYLLMDGLSAEEKYGLHLNNLHAHRYLRQTLREDisaaehsLNREKFAVLKQALNVIGF 654  Bos grunniens...
ERE91016      604 TYMLEKSRLVTQPPGQGSFLIFSWLMDGLSMEEKCGLHLSNCCAHRYMNQGMQEDvstaersLNKERLAVLKHALNVVGF 683  Chinese hamster
NP_001074866  574 TYMLEKSRVVAQPPGQGTFLIFSWLMDGLSSEEKCGLHLNNFCAHRYVSQGMREDvstaehsLNKERLAALKHALNVIGF 653  house mouse
Q5DU14        574 TYMLEKSRVVAQPPGQGTFLIFSWLMDGLSSEEKCGLHLNNFCAHRYVSQGMREDvstaehsLNKERLAALKHALNVIGF 653  house mouse
AAF20150      575 TYMLEKPRLVAQPPGQGSFLIFSWLMDGLSAEEKCGLHLSNFCAHRYVSQGMREDvstaersLNKERLADLKHALNVIGF 654  Norway rat
NP_620248     575 TYMLEKPRLVAQPPGQGSFLIFSWLMDGLSAEEKCGLHLSNFCAHRYVSQGMREDvstaersLNKERLADLKHALNVIGF 654  Norway rat
Q9ERC1        575 TYMLEKPRLVAQPPGQGSFLIFSWLMDGLSAEEKCGLHLSNFCAHRYVSQGMREDvstaersLNKERLADLKHALNVIGF 654  Norway rat
XP_416950     597 TYMLEKSRVIMQPLNQSNFHVFYLMMDGLSAEEKYTLYLSNLSTHRYLSQTELEEtmltanpQNREKLTVLKEALSAMGF 676  chicken

Feature 1                                                                                         
ELK24949      655 SNLEVENLFVILAAILHVGDIRFTslteedsafvsDLQLLEQVAGMLQVSADELVSALTTDIQYFKGDmITRRHTIEMAE 734  Myotis davidii
NP_001185879  677 SSLEVENLFVILAAILHLGDIRFTalnegnsafvsDLQLLEQVAGMLQVSTDELASALTTDIQYFKGDmIIRRHTIQIAE 756  human
ELR50107      655 SNLEVENLCVILAAVLHLGDVGFTavseadsalvsDLQLLEQVAGMLQVSPDELASALTTDIQYFKGEvTTRRHTVAMAE 734  Bos grunniens...
ERE91016      684 SSWEVENLFVILAAILHLGDIQFTalteadsafvsDLQLLEQVAGMLQVSTDELASALTTDIQYLKGDvIIRRHTTQIAA 763  Chinese hamster
NP_001074866  654 STLEVENLFVILSAILHIGDIQFTalteadsafvsDLQLLEQVAGMLQVSTDELASALTTDIQYFKGDvIIRRHTIQMAA 733  house mouse
Q5DU14        654 STLEVENLFVILSAILHIGDIQFTalteadsafvsDLQLLEQVAGMLQVSTDELASALTTDIQYFKGDvIIRRHTIQMAA 733  house mouse
AAF20150      655 SALEVENLFAILSAILHIGDIQFTalteadsafvsDLQLLEQVADMLQVSTDELASALTTDIQYFKGDvIIRRHTTQIAA 734  Norway rat
NP_620248     655 SALEVENLFAILSAILHIGDIQFTalteadsafvsDLQLLEQVADMLQVSTDELASALTTDIQYFKGDvIIRRHTTQIAA 734  Norway rat
Q9ERC1        655 SALEVENLFAILSAILHIGDIQFTalteadsafvsDLQLLEQVADMLQVSTDELASALTTDIQYFKGDvIIRRHTTQIAA 734  Norway rat
XP_416950     677 NSLEVENLFVILSAILHLGDIRFTtltdtetalvsDLQLLEQVAGMLQVSPDELASALTTDVQYFKGDmIVRRHTIEMAE 756  chicken

Feature 1                                                    ######                               
ELK24949      735 FYRDLLAKSLYSRLFSFLVNSMNCCLQSQDEpsSMQTLHIGILDIFGFEEFQKNEFEQLCVNMTNEKIHHYINEVLFLHE 814  Myotis davidii
NP_001185879  757 FFRDLLAKSLYSRLFSFLVNTMNSCLHSQDEqkSMQTLDIGILDIFGFEEFQKNEFEQLCVNMTNEKMHHYINEVLFLHE 836  human
ELR50107      735 FYRDLLAKSLYSRLFSFLVNAVNCRLRGDEEpsSSQTWGIGILDIFGFEEFQKNEFEQLCVNMTNEKMHHYINEVLFLQE 814  Bos grunniens...
ERE91016      764 FYRDLLAKSLYSRLFGFLINTVNCCLQNQDEyrSPQTLDIGILDIFGFEEFQKNEFEQLCVNLTNEKMHHYIQEVLFLQE 843  Chinese hamster
NP_001074866  734 FYRDLLAKSLYSRLFGFLINTVNCCLQNQDEykSLQTLDIGILDIFGFEEFQKNEFEQLCVNLTNEKMHHYIQEVLFLQE 813  house mouse
Q5DU14        734 FYRDLLAKSLYSRLFGFLINTVNCCLQNQDEykSLQTLDIGILDIFGFEEFQKNEFEQLCVNLTNEKMHHYIQEVLFLQE 813  house mouse
AAF20150      735 FYRDLLAKSLYSRLFGFLINTVNCCLQSQDEykSLQTLDIGILDIFGFEEFQKNEFEQLCVNLTNEKMHHYIQEVLFLQE 814  Norway rat
NP_620248     735 FYRDLLAKSLYSRLFGFLINTVNCCLQSQDEykSLQTLDIGILDIFGFEEFQKNEFEQLCVNLTNEKMHHYIQEVLFLQE 814  Norway rat
Q9ERC1        735 FYRDLLAKSLYSRLFGFLINTVNCCLQSQDEykSLQTLDIGILDIFGFEEFQKNEFEQLCVNLTNEKMHHYIQEVLFLQE 814  Norway rat
XP_416950     757 FYRDLLAKSLYGRLFSFLVNTINCYLQNQDEaeSDRIFEIGILDIFGFEEFQRNTFEQLCVNMTNEKIHQYISEVLFLQE 836  chicken

Feature 1                                                                                         
ELK24949      815 QTECVQEGITMETAYSpgnqTGVLDFFFQKPSGFLSLLDEESQMIWSMETNLPKKLQsllessntnavyspmkdgngnva 894  Myotis davidii
NP_001185879  837 QVECVQEGVTMETAYSpgnqNGVLDFFFQKPSGFLTLLDEESQMIWSVESNFPKKLQsllessntnavyspmkdgngnva 916  human
ELR50107      815 QAECVQEGVTMETAYSlgnqTGVLDFFFQKPSGFLSLLDEESQMIWSVEPSLSKKLHgllessntnavyspvkdgngnla 894  Bos grunniens...
ERE91016      844 QTECVQEGVAMETAYSpgnqTGVLDFFFQKPSGFFSLLDEESQVTWSVEPNFPRKLQsllessntntvyssikdgngnva 923  Chinese hamster
NP_001074866  814 QTECVQEGVAMETACSpgnqAGVLDFFFQKPSGFFSLLDEESQVIWSGEPNLPRKLQgllessntnavyspvkdgngnva 893  house mouse
Q5DU14        814 QTECVQEGVAMETACSpgnqAGVLDFFFQKPSGFFSLLDEESQVIWSGEPNLPRKLQgllessntnavyspvkdgngnva 893  house mouse
AAF20150      815 QTECVQEGVAMETACSpgnqAGVLDFFFQKPSGFFSLLDEESQAIWSVEPNLPRKLQgllessntnavyspmkdgngnva 894  Norway rat
NP_620248     815 QTECVQEGVAMETACSpgnqAGVLDFFFQKPSGFFSLLDEESQAIWSVEPNLPRKLQgllessntnavyspmkdgngnva 894  Norway rat
Q9ERC1        815 QTECVQEGVAMETACSpgnqAGVLDFFFQKPSGFFSLLDEESQAIWSVEPNLPRKLQgllessntnavyspmkdgngnva 894  Norway rat
XP_416950     837 QTECVQEGITIEAVYSpanhTAALDFFFQKPSGFLSMLDEESQSNWSVEQSLSKRIQsyldtsdtnivysstkdgngnla 916  chicken

Feature 1                                                                                         
ELK24949      895 lkdqgtAFTIMHYAGRVMYEIVGAIEKNKDSLSRNLSFVMKTSENVVINHLFQSKLsqtgsllssypsfkfrghksalln 974  Myotis davidii
NP_001185879  917 lkdhgtAFTIMHYAGRVMYDVVGAIEKNKDSLSQNLLFVMKTSENVVINHLFQSKLsqtgslvsaypsfkfrghksalls 996  human
ELR50107      895 lrdqgaAFTVMHYAGRVMYEAVGAIEKNKDSLSQNLLFVMKTSENVVINHLFQSKLsqtgalvssspsfkfrghksarls 974  Bos grunniens...
ERE91016      924 fkgqgpVFTVMHYAGRVMYEIGGAVERNKDSLSQNLLFVMKTSENVVISHLFQSKLsqmgslissypsfkfrghkstils 1003 Chinese hamster
NP_001074866  894 fkgqgaAFTVMHYAGRVMYEMGGAVERNKDSLSQNLLFVMKTSENVVISHLFQSKLsqtgslissypsfkfgghkstlls 973  house mouse
Q5DU14        894 fkgqgaAFTVMHYAGRVMYEMGGAVERNKDSLSQNLLFVMKTSENVVISHLFQSKLsqtgslissypsfkfgghkstlls 973  house mouse
AAF20150      895 fkgqgaAFTVMHYAGRVTYEIRGAVERNKDSLSQNLLFVMKTSENVVISHLFQSKLsptgslissypsfkfgghksslls 974  Norway rat
NP_620248     895 fkgqgaAFTVMHYAGRVTYEIRGAVERNKDSLSQNLLFVMKTSENVVISHLFQSKLsptgslissypsfkfgghksslls 974  Norway rat
Q9ERC1        895 fkgqgaAFTVMHYAGRVTYEIRGAVERNKDSLSQNLLFVMKTSENVVISHLFQSKLsptgslissypsfkfgghksslls 974  Norway rat
XP_416950     917 pkeqgsTFTVMHYAGRVTYEIAGAVEKNKDSLSQNLIFVMKTSENVVINQLFQSKLtqtgslvppyhslkfkgckaamln 996  chicken

Feature 1                                                                                         
ELK24949      975 kkmtasstigenrnylelskllkkkgtstflqrlerggpVTIASQLRKSLTDIIGKLQKCTPHFIHCIKPNNSKLPDTFD 1054 Myotis davidii
NP_001185879  997 kkmtassiigenknylelskllkkkgtstflqrlergdpVTIASQLRKSLMDIIGKLQKCTPHFIHCIRPNNSKLPDTFD 1076 human
ELR50107      975 krmtassmmgenrnylelskllkkkgnstflqrldrggpATIASQLRKTLTDITGKLQKCTPHFIHCIKPNNSKLPDTFD 1054 Bos grunniens...
ERE91016     1004 krtassm-igtnknylelskllkkkgpstflqrlergdpVTTASQLTKSLADITGKLQRGSPHFIHCIKPNTSQLPGVFD 1082 Chinese hamster
NP_001074866  974 krtassm-vgvnknylelskllkkkgtstflqrlergepATAASQLTKSLADITAKLQRGSPHFILCIKPNTSQLPGVFD 1052 house mouse
Q5DU14        974 krtassm-vgvnknylelskllkkkgtstflqrlergepATAASQLTKSLADITAKLQRGSPHFILCIKPNTSQLPGVFD 1052 house mouse
AAF20150      975 kriassm-vgvnknylelskllkkkgtctflqrlergdpATTASQLTKSLADITAKLQKGSPHFILCVKPNTSQLPGVFD 1053 Norway rat
NP_620248     975 kriassm-vgvnknylelskllkkkgtctflqrlergdpATTASQLTKSLADITAKLQKGSPHFILCVKPNTSQLPGVFD 1053 Norway rat
Q9ERC1        975 kriassm-vgvnknylelskllkkkgtctflqrlergdpATTASQLTKSLADITAKLQKGSPHFILCVKPNTSQLPGVFD 1053 Norway rat
XP_416950     997 kktsvacasgetkkyvelskllkkkgtssflqklerggpTTVAVQLRKSLIDIIGKLQNCTPHSIHCIKPNNSKLPDTFD 1076 chicken

Feature 1                                                                                        
ELK24949     1055 NFYVSAQLQYIGVLAMVKIIRYGYPVRLSFSDCLSRYKPLVEtlpgEKKKLSAEEKCRLVLQQCTLPGWQMGVRKVFLK 1133 Myotis davidii
NP_001185879 1077 NFYVSAQLQYIGVLEMVKIFRYGYPVRLSFSDFLSRYKPLADtflrEKKEQSAAERCRLVLQQCKLQGWQMGVRKVFLK 1155 human
ELR50107     1055 NFYVSAQLQYVGILEMVKSIRHGYPVRLSFSDFLSRYRPLAEtlpgNERTLPAEERCRLALKHCPLPGWQIGVRKVFLK 1133 Bos grunniens ...
ERE91016     1083 HFYVSAQLQYLGVLGLVKLFRYGYPVRPSFEDFLSRYEPLASvl-lGEKGQSAEERCRLVLQRCKLQGWQVGLHKVFLK 1160 Chinese hamster
NP_001074866 1053 HFYVSAQLQYLGVLGLVRLFRSGYPVRPSFEDFLSRYEPLASvllgETKGQAAEERCRLVLQRCKLQGWQIGVHKVFLK 1131 house mouse
Q5DU14       1053 HFYVSAQLQYLGVLGLVRLFRSGYPVRPSFEDFLSRYEPLASvllgETKGQAAEERCRLVLQRCKLQGWQIGVHKVFLK 1131 house mouse
AAF20150     1054 HFYVSAQLQYLGVLGLVRLFRYGYPVRPSFEDFLSRYEPLASvllgEKKGQPAEERCRLVLQRCKLQGWQMGVHKVFLK 1132 Norway rat
NP_620248    1054 HFYVSAQLQYLGVLGLVRLFRYGYPVRPSFEDFLSRYEPLASvllgEKKGQPAEERCRLVLQRCKLQGWQMGVHKVFLK 1132 Norway rat
Q9ERC1       1054 HFYVSAQLQYLGVLGLVRLFRYGYPVRPSFEDFLSRYEPLASvllgEKKGQPAEERCRLVLQRCKLQGWQMGVHKVFLK 1132 Norway rat
XP_416950    1077 NFYVSAQLQYIGVLDMVKIIRYGYPFRFSFTDFLSRYKDLADta-aGEKKLSAKERCRLVLQQCKLQGWQIGIRKVFLK 1154 chicken

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