Conserved Protein Domain Family
MYSc_Myo10

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cd14873: MYSc_Myo10 
class X myosin, motor domain
Myosin X is an unconventional myosin motor that functions as a monomer. In mammalian cells, the motor is found to localize to filopodia. Myosin X walks towards the barbed ends of filaments and is thought to walk on bundles of actin, rather than single filaments, a unique behavior. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. C-terminal to the head domain are a variable number of IQ domains, 2 PH domains, a MyTH4 domain, and a FERM domain. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.
Statistics
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PSSM-Id: 276840
Aligned: 24 rows
Threshold Bit Score: 1216.56
Created: 7-Jan-2013
Updated: 2-Oct-2020
Structure
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Aligned Rows:
  next features
Feature 1:ATP binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                    ####### ##                                           
BAA34519      130 GSIMYNLFQRYKRNQIYTYIGSILASVNPYQPIAgLYEPATMEQYSRRHLGELPPHIFAIANECYRCLWKRHDNQCILIS 209  human
D3ZJP6         77 GSIMYNLFQRYKRNQIYTYIGSIIASVNPYQPIAgLYERATMEQYSRCHLGELPPHIFAIANECYRCLWKRHDNQCVLIS 156  Norway rat
EOB07817       70 GSIMHNLFQRYQQDKIYTYIGSIVASVNPYKTIPgLYDCTAMERYSKHHMGEIAPHIFAVANECYRCLWKRHDNQCILIS 149  mallard
P79114         77 GAIMHNLYQRYKRNQIYTYIGSIIASVNPYKTITgLYSRDAVDRYSRCHLGELPPHVFAIANECYRCLWKRHDNQCVLIS 156  cattle
NP_776819      77 GAIMHNLYQRYKRNQIYTYIGSIIASVNPYKTITgLYSRDAVDRYSRCHLGELPPHVFAIANECYRCLWKRHDNQCVLIS 156  cattle
CAB56466       77 VAIMYNLFQRYKRNQIYTYIGSIIASVNPYQPIAgLYERATMEEYSRCHLGELPPHIFAIANECYRCLWKRHDNQCVLIS 156  house mouse
EHB02939       60 GSIMYNLFQRYRRNQIYTYIGSILASVNPYQPIAgLYEGATMEQYSRCHLGELPPHIFAIANECYRCLWKRHDNQCVLIS 139  naked mole-rat
CAG10354       72 AAIMHNLYQRYQKDNIYTNIGSILAAVNPYKQIPgLYDLDRVDLYSKHHLGELPPHIFAVANECYRCIWKRHDSQCVLIS 151  spotted green...
ELR54390       74 GAIMHNLYQRYKRNQIYTYIGSIIASVNPYKTISgLYSRDAVDRYSRCHLGELPPHVFAIANECYRCLWKRHDNQCVLIS 153  Bos grunniens...
NP_001086419   77 ASIMLNLRLRYQQDKIYTNIGSILASVNPYKPIAgLYDEKCVDLYSRHHFGELPPHIFAIANECYRCLWKRHDSQCVLIS 156  African clawe...
Feature 1         ########                                             ###########                
BAA34519      210 GESGAGKTESTKLILKFLSVISQqslelslkektSCVERAILESSPIMEAFGNAKTVYNNNSSRFGKFVQLNICQKGNIQ 289  human
D3ZJP6        157 GESGAGKTESTKLILKFLSVISQhsldlclqeksSSVEQAILQSSPIMEAFGNAKTVYNNNSSRFGKFVQLNICQKGNIQ 236  Norway rat
EOB07817      150 GESGAGKTESTKLILKFLSAMSQhslelscrektSCVEQAILESSPIMEAFGNAKTVYNNNSSRFGKFIQLNICQKGNIQ 229  mallard
P79114        157 GESGAGKTESTKLILKFLSAISQqsvdlsskektSSVEQAILESSPIMEAFGNAKTVYNNNSSRFGKFVQLNIGQKGNIQ 236  cattle
NP_776819     157 GESGAGKTESTKLILKFLSAISQqsvdlsskektSSVEQAILESSPIMEAFGNAKTVYNNNSSRFGKFVQLNIGQKGNIQ 236  cattle
CAB56466      157 GESGAGKTESTKLILKFLSVISQqtldlglqektSSVEQAILQSSPIMEAFGNAKTVYNNNSSRFGKFVQLNICQQGNIQ 236  house mouse
EHB02939      140 GESGAGKTESTKLLLQFLSVLSQqslelsvkekaSRVEQAILGSSPIMEAFGNAKTVYNNNSSRFGKFVQLHLCQKGNIQ 219  naked mole-rat
CAG10354      152 GESGAGKTESTKLLLQFLSVMSQnsagapsseksTRVEQAIVQSSPIMEAFGNAKTVYNNNSSRFGKFIQLHFSECGNIQ 231  spotted green...
ELR54390      154 GESGAGKTESTKLILKFLSAISQqsvdlsskektSSVEQAILESSPIMEAFGNAKTVYNNNSSRFGKFVQLNIGQKGNIQ 233  Bos grunniens...
NP_001086419  157 GESGAGKTESTKLLLKFLSSMSQnsagg--ggmqTHVEKAIMESSPILEAFGNAKTVYNNNSSRFGKFIQLHFSQQGHIQ 234  African clawe...
Feature 1                                                                                         
BAA34519      290 GGRIVDYL---LEKNRVVRQNPGERNYHIFYALLaGLEHEEREEfyl-stPENYHYLNQSGCVEDKTISDQESFREVITA 365  human
D3ZJP6        237 GGRIVDYL---LEKNRVVRQNPGERNYHIFYALLaGLDQGEREEfyl-slPENYHYLNQSGCTEDKTISDQESFRQVIEA 312  Norway rat
EOB07817      230 GGRIIDYL---LEKNRVVRQNPGERNYHIFYALLaGVEEREKDAfyl-svPENYHYLNQSGCIADKTINDKDSFREVITA 305  mallard
P79114        237 GGRIVDYL---LEKNRVVRQNPGERNYHIFYALLaGLGHEEREEfyl-svPENYHYLNQSGCVTDRTISDQESFREVIMA 312  cattle
NP_776819     237 GGRIVDYL---LEKNRVVRQNPGERNYHIFYALLaGLGHEEREEfyl-svPENYHYLNQSGCVTDRTISDQESFREVIMA 312  cattle
CAB56466      237 GGRIVDYL---LEKNRVVRRIPGERNYHIFYALLaGLDQEEREEfyl-slPENYHYLNQSGCTEDKTISDQESFRQVITA 312  house mouse
EHB02939      220 GGRIVDCIl--LHCNRVVRQNPGERNYHIFYALLaGLGPGEREEfyl-svPENYHYLNQSGCVEDKTINDQESFKEVITA 296  naked mole-rat
CAG10354      232 GGCIIDYL---LEKNRVVRQNPGERNYHIFYALLaGATKEHKNLyfledsPELFHYLSQSGCLKDKSLNDKELFNSVMEA 308  spotted green...
ELR54390      234 GGRIVDCIlfhLAFNRVVRQNPGERNYHIFYALLaGLGHEEREEfyl-svPENYHYLNQSGCVTDRTISDQESFREVIMA 312  Bos grunniens...
NP_001086419  235 GGRVVDYL---LEKTRVTRQSPGERNYHIFYALLsGANKEEKEAlal-sdPQTYQYLSTSGCVTAEGLNDKDMYEKVLAA 310  African clawe...
Feature 1                                                                                         
BAA34519      366 MDVMQFSKEEVREVSRLLAGILHLGNIEFITAGGAQVSFKTALGRSAELLGLDPTQLTDALTQRSMFLRGEEIlTPLNVQ 445  human
D3ZJP6        313 MEVMQFSKEEVREVLRLLAGILHLGNIEFITAGGAQISFKTALGRSAELLGLDPTQLTDALTQRSMFLRGEEIlTPLSVQ 392  Norway rat
EOB07817      306 MEVMQFSKEEVREVLRLLAGILHLGNVEFITAGGAQVSFKTALGRSAELLGLDSTQLTEALTQRSMILRGEEIlTPLSIQ 385  mallard
P79114        313 MEVMQFSKEEVREVLRLLAGILHLGNIEFITAGGAQVSFKTALGRSAELLGLDPAQLTDALTQRSMFLRGEEIlTPLNVQ 392  cattle
NP_776819     313 MEVMQFSKEEVREVLRLLAGILHLGNIEFITAGGAQVSFKTALGRSAELLGLDPAQLTDALTQRSMFLRGEEIlTPLNVQ 392  cattle
CAB56466      313 MEVMQFSKEEVREVLRLLAGILHLGNIEFITAGGAQIPFKTALGRSADLLGLDPTQLTDALTQRSMILRGEEIlTPLSVQ 392  house mouse
EHB02939      297 MEVMQFSKDEVGEVLRLLAGILHLGNVEFITAGGAQVPFKTALGRSAELLGLDPTPLTDALTQRSMFLRGEEIlTPLSVQ 376  naked mole-rat
CAG10354      309 LKVLQFTEEEIRDMFKLLSGVLQLGNIEFMTAGGAQITTKQVVTNASELLGLDAFQLSEVLTQRSIILRGEEIcSPLTIE 388  spotted green...
ELR54390      313 MEVMQFSKEEVREVLRLLAGILHLGNIEFITAGGAQVSFKTALGRSAELLGLDPAQLTDALTQRSMFLRGEEI-LTPLNV 391  Bos grunniens...
NP_001086419  311 LQVMDFSDEEIREVWKLLSGILQLGNLEFMTAGGAQITSKAVLGDAADLLGLDSFQLSEVLTQRSMILRGEEIsSPLTVE 390  African clawe...
Feature 1                                                  ######                                 
BAA34519      446 QAVDSRDSLAMALYACCFEWVIKKINSRIKgNEDFKSIGILDIFGFENFEVNHFEQFNINYANEKLQEYFNKHIFSLEQL 525  human
D3ZJP6        393 QAVDSRDSLAMALYARCFEWVIKKINSRIKgKDDFKSIGILDIFGFENFEVNHFEQFNINYANEKLQEYFNKHIFSLEQL 472  Norway rat
EOB07817      386 QAIDSRDSMAMALYSQCFAWVIKKINSRIKsKEDFKSIGILDIFGFENFEVNRFEQFNINYANEKLQEYFNKHIFSLEQL 465  mallard
P79114        393 QAADSRDSLAMALYARCFEWVIKKINSRIKgKDDFKSIGILDIFGFENFEVNHFEQFNINYANEKLQEYFNKHIFSLEQL 472  cattle
NP_776819     393 QAADSRDSLAMALYARCFEWVIKKINSRIKgKDDFKSIGILDIFGFENFEVNHFEQFNINYANEKLQEYFNKHIFSLEQL 472  cattle
CAB56466      393 QAVDSRDSLAMALYARCFEWVIKKINSRIKgKDDFKSIGILDIFGFENFEVNHFEQFNINYANEKLQEYFNKHIFSLEQL 472  house mouse
EHB02939      377 QAVDSRDSLAMALYARCFEWVIKKINSRIKgRDDFKSIGILDIFGFENFEVNHFEQFNINYANEKLQEYFNKHIFSLEQL 456  naked mole-rat
CAG10354      389 QAVDSRDSVAMALYSQCFSWIILKINQKIKgKENFKSIGILDIFGFENFEVNRFEQFNINYANEKLQEYFNKHIFSLEQL 468  spotted green...
ELR54390      392 QYVYSRDSLAMALYARCFEWVIKKINSRIKgKDDFKSIGILDIFGFENFEVNHFEQFNINYANEKLQEYFNKHIFSLEQL 471  Bos grunniens...
NP_001086419  391 QATDSRDSLAMALYAQCFSWLLSKINARIRgKENFKSVGILDIFGFENFQVNRFEQFNINYANEKLQEYFNKHIFSLEQL 470  African clawe...
Feature 1                                                                                         
BAA34519      526 EYSREGLVWEDIDWIDNGECLDLIEKKLGLLALINEESHFPQATDSTLLEKLHSQHANNHFYVKPRVAVNNFGVKHYAGE 605  human
D3ZJP6        473 EYSREGLVWEDIDWIDNGECLDLIEKKLGLLALINEESHFPQATDSTLLEKLHNQHANNHFYVKPRVAVNNFGVKHYAGE 552  Norway rat
EOB07817      466 EYSREGLVWEDIDWTDNGECLDLIEKKLGLLALINEESHFPQATDSTLLEKLNIQHANNPFYVKPRVAAHNFGVKHYAGE 545  mallard
P79114        473 EYSREGLVWEDIDWIDNGECLDLIEKKLGLLALINEESHFPQATDSTLLEKLHNQHANNHFYVKPRVAVNNFGVKHYAGE 552  cattle
NP_776819     473 EYSREGLVWEDIDWIDNGECLDLIEKKLGLLALINEESHFPQATDSTLLEKLHNQHANNHFYVKPRVAVNNFGVKHYAGE 552  cattle
CAB56466      473 EYSREGLVWEDIDWIDNGECLDLIEKKLRLLALINEESHFPQATDSTLLEKLHSQHANNHFYVKPRVAVNNFGVKHYAGE 552  house mouse
EHB02939      457 EYTREGLVWEDINWIDNGECLDLIEKKLGLLALINEESHFPQATDSTLLEKLHNQHANNHFYVKPRVAVNNFGVKHYAGE 536  naked mole-rat
CAG10354      469 EYNREGVQWDAIDWMDNAECLDLIEKKLGLLALVNEESRFPKGTDFTLLEKLHSRHSTNPYYVKPRLADHQFGIKHYAGE 548  spotted green...
ELR54390      472 EYSREGLVWEDIDWIDNGECLDLIEKKLGLLALINEESHFPQATDSTLLEKLHNQHANNHFYVKPRVAVNNFGVKHYAGE 551  Bos grunniens...
NP_001086419  471 EYNREGIHWDAIDWMDNAECLDLIEKKLGILALINEESRFPKGTDFTLLEKFHNQHSNNPHYVKPRVTEHQFGIKHYAGE 550  African clawe...
Feature 1                                                                                         
BAA34519      606 VQYDVRGILEKNRDTFRDDLLNLLRESRFDFIYDLFEHVSSRNNqdtlkcgskhrrptvSSQFKDSLHSLMATLSSSNPF 685  human
D3ZJP6        553 VQYDVRGILEKNRDTFRDDLLNLLRESRFDFIYDLFEHISSRNNqdtlkcgskhrrptvSSQFKDSLHSLMATLSSSNPF 632  Norway rat
EOB07817      546 VQYDVRGILEKNRDTFRDDLLNLLRESSLDFIYDLFEHVSSRNNqdtlkcgskhrkptvSLQFKESLHSLMATLSSSNPF 625  mallard
P79114        553 VQYDVRGILEKNRDTFRDDLLNLLRESRFDFIYDLFEHVSSRNNqdtlkcgskhrrptvSSQFKDSLHSLMATLSASNPF 632  cattle
NP_776819     553 VQYDVRGILEKNRDTFRDDLLNLLRESRFDFIYDLFEHVSSRNNqdtlkcgskhrrptvSSQFKDSLHSLMATLSASNPF 632  cattle
CAB56466      553 VQYDVRGILEKNRDTFRDDLLNLLRESRFDFIYDLFEHVSSRNNqdtlkcgskhrrptvSSQFKDSLHSLMATLSSSNPF 632  house mouse
EHB02939      537 VQYDVRGILEKNRDTFRDDLLNLLRESRFDFIYDLFEHVSSRSSqdtlkcgsklrrptvSSQFKDSLHSLMATLSSSNPF 616  naked mole-rat
CAG10354      549 VLYDVKGILEKNRDTFRDDILNLLKDSRLDFIYDLFEKVGSRNNeekmgta--rrkptvSSQFRDSLHALMATLSVSNPF 626  spotted green...
ELR54390      552 VQYDVRGILEKNRDTFRDDLLNLLRESRFDFIYDLFEHVSSRNNqdtlkcgskhrrptvSSQFKDSLHSLMATLSASNPF 631  Bos grunniens...
NP_001086419  551 VTYDVQEFLEKNRDTFRDDILNMLRDSRLDFVYDLFEKVCSRNSgetlkmgtqrkkptvSSQFRESLHSLMAMLSTSNPF 630  African clawe...
Feature 1                                                                                         
BAA34519      686 FVRCIKPNMQKMPDQFDQAVVLNQLRYSGMLETVRIRKAGYAVRRPFQDFYKRYKVLMRNLALPEDv------------- 752  human
D3ZJP6        633 FVRCIKPNTQKMPDQFDQAVVLNQLRYSGMLETVRIRKAGYAVRRPFQDFYKRYKVLMRDLALPEDi------------- 699  Norway rat
EOB07817      626 FIRCIKPNVQKMPDQFDQTVVLNQLRYSGMLETVRIRRAGFPVRRPFQDFYKRYKVLMRNLTLPEDl------------- 692  mallard
P79114        633 FVRCIKPNMQKMPDQFDQAVVVNQLRYSGMLETVRIRKAGYAVRRPFQDFYKRYKVLMRNVALPEDi------------- 699  cattle
NP_776819     633 FVRCIKPNMQKMPDQFDQAVVVNQLRYSGMLETVRIRKAGYAVRRPFQDFYKRYKVLMRNVALPEDi------------- 699  cattle
CAB56466      633 FVRCIKPNTQKMPDQFDQVVVLNQLRYSGMLETVRIRKAGYAVRRPFQDFYKRYKVLMRNLALPDDi------------- 699  house mouse
EHB02939      617 FIRCIKPNMQKMPDHFDQAVVLNQLRYSGMLETVRIRKAGYAVRRPFQDFYKRQALRGPYNVLARNlvlp---------- 686  naked mole-rat
CAG10354      627 FIRCIKPNMEKNPNVFDPEVVLNQLRYSGMLETVKIRRAGFPVRRTFRDFFSRLASLISHRLNLLLllfvlllclnfisl 706  spotted green...
ELR54390      632 FVRCIKPNMQKMPDQFDQAVVVNQLRYSGMLETVRIRKAGYAVRRPFQDFYKRQDGVAETLLFKEIgervvargdtgyk- 710  Bos grunniens...
NP_001086419  631 FIRCIKPNTEKLSNTFNPDVVLNQLRYSGMLETVKIRRAGFPVRRLYQDFVSRYKMLLKNIKATDDv------------- 697  African clawe...
Feature 1                                                           
BAA34519      753 ----------------------rGKCTSLLQLYDASNSEWQLGKTKVFLR 780  human
D3ZJP6        700 ----------------------rGKCTVLLQFYDASNSEWQLGKTKVFLR 727  Norway rat
EOB07817      693 ----------------------nEKCAVLLRLYDNTSTEWQLGKNKVFLR 720  mallard
P79114        700 ----------------------rGKCTALLQLYDASNSEWQLGKTKVFLR 727  cattle
NP_776819     700 ----------------------rGKCTALLQLYDASNSEWQLGKTKVFLR 727  cattle
CAB56466      700 ----------------------rGKCTVLLQVYDASNSEWQLGKTKVFLR 727  house mouse
EHB02939      687 -------------------edvrGRCAALLQGYDGSGSEWQLGKTKVFLR 717  naked mole-rat
CAG10354      707 plrykiimkdripaaaaaaaddkKKSTDLLIKYDKTKKEWQLGKTKVFMK 756  spotted green pufferfish
ELR54390      711 ----------vlmrnvampedirGKCTALLQLYDASNSEWQLGKTKVFLR 750  Bos grunniens mutus
NP_001086419  698 ----------------------rGKCATFLQSYEGTKKEWQLGKTKVFLK 725  African clawed frog

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